When the Mexican drug cartel comes after Teresa Mendoza with a vengeance, she is forced to run and do whatever it takes to survive. Now, her fate is sealed in the dangerous narco world forever.

Teresa has to prove her worth to Camila. Meanwhile, Epifanio gets closer in his hunt for Teresa. Back in Mexico, Brenda desperately tries to find Teresa and hide from the cartel.

Teresa witnesses a horrific event that forces her to advance her plans. Now, safely in Dallas, Brenda needs money to survive, and starts assembling a rag tag team to help her sell drugs.

Camila, riddled with debt and short on supply, grows desperate and ponders giving Teresa up. Meanwhile, Brenda's burgeoning drug enterprise creates a rift between her and Tony.

On her day off, Teresa is hunted by a sicario from her previous life while on the road.

Camila sends Teresa out on a major drug operation to test her loyalty. In secret, Camila makes her first big move to take over Epifanio’s cartel. Meanwhile, Brenda plots her escape to America.

Camila sends Teresa out on a life-threatening, multi- million dollar midnight mission. Pressured by a lack of supply, Brenda puts her crew in the line of fire.

Teresa's loyalties are tested when she is asked to assassinate a DEA mole.

With their payment deadline looming, Teresa and Camila need to find a new distributor, but their plans become threatened.

Rocked by a deeply personal tragedy, Teresa battles a dangerous sicario and a mutiny within her own ranks.

Teresa expands her business and proves herself to a smuggler who offers her a business opportunity.

While Javier and Boaz deal with a personal problem, Teresa gets involved in a deadly turf war.

A deadly mistake mars Teresa’s first solo drug run and she soon finds herself in peril. Meanwhile, Brenda and Tony make the risky escape to Dallas.

Camila returns to Mexico to protect her life, while James hunts Teresa down. Meanwhile Teresa finds herself in grave danger taking Maria through the tunnel to Mexico.

Teresa and Brenda risk everything in a game of extortion. Camila takes further steps to overtake Epifanio’s empire.

Teresa brokers a deal with an eccentric smuggler, Camila struggles to rebuild her empire, and Epifanio takes on a new partner he may not be able to control.

While trying to destroy Epifanio's drug smuggling tunnels, Teresa and James come face-to-face with a group of American border vigilantes.

Teresa tries to escape her captors with the help of an unexpected ally.

In a bold plan to take over all drug distribution in Phoenix, Teresa makes a deal with the devil.

Returning to Bolivia, Teresa risks her life to prove her loyalty to El Santo.

Teresa's deal with a smuggler goes sieways when a local kingpin discovers she's smuggling cocaine.

A corrupt judge wants in on Teresa's deal when he learns about her business.

El Gordo introduces Teresa to Russian drug queenpin Oksana in the hopes of forging a partnership.

Aligning with the Jimenez Cartel, Camila’s operation goes underground. Teresa and Brenda try to start a new life utilizing knowledge from Güero’s book.

Teresa and crew rig a high-stakes narco horse race, but old enemies — and old flames — threaten to tear everything apart.