Long-time partners and best friends, police detectives John Conaty and Ray Giacomelli never thought things would happen the way they did on a Pittsburg, Cal., murder case, where the prime suspect is a killer who was put behind bars years earlier.

One year into the most demanding case of his career, Riverside, Cal., senior investigator Bob Creed arrives at the scene of the 16th murder in a string of slayings. But this one is different. It's on his grandfather's property, where he spent most of his youth.

Indianapolis detective Christine Mannina arrives on the scene of an execution-style shooting that's left one man dead and another in critical condition. She knows she must convince a reluctant witness to come forward and put her life on the line.

Sacramento FBI Special Agent Jeff Rinek sought out the worst cases because he was the best at solving them. After being kidnapped at gunpoint from his family home, Rinek knows the chances of finding 7-month-old Frankie Proctor alive are slim to none.

A missing person case turns suspicious when a well-liked Wausau, Wis., man doesn't show up for work one morning. Investigator Larry Woebbeking finds himself in an unexpected predicament when the girlfriend of the victim appears to have fallen for him.

In Lake County, Fla., Chief Investigator Rocky Harris is called in to investigate a haunting case, the rape and murder of a young girl; wading through bad police work and dead ends, Harris is sickened when he uncovers the identity of the killer.

A young woman fails to return to her home in Boulder, Colo, and she is later found decapitated; Detective Steve Ainsworth soon learns she was part of a mysterious Apostolic church group, led by a pastor who has a reputation for preying on the weak.

Investigator Clarence Douglas tackles the case of Angel Doe, a little girl found dead in a ditch near the Houston Bayou, promising not to neglect her in death, like she was in life.

A hardened LAPD homicide detective has his eyes opened by the mother of a senselessly murdered woman.

A rookie homicide detective becomes too close to the mother of a murder victim and shares the dark secrets that led to the son's death with her.

Detective Eddie Herman of Cobb county, Georgia is a homicide detective at the top of his game, solving major high profile crimes. But when a missing persons turns into a double homicide, Eddie's ego gets in way and the killer walks free.

When all signs point to suspects with friends in high places in the horrific murder of a young woman, Texas Ranger Phil Ryan goes against the grain to get justice for this discarded victim.

A suspicious hit and run rips a Lakeland, Florida family apart. Detective Tommy Ray takes the grieving wife and daughter under his wing. But when the case goes cold, an unexpected encounter makes him realize they aren't who he thinks they are.

Still troubled after killing someone in the line of duty, Detective C.W. Jensen faces the most haunting case of his career: A missing child becomes a harrowing pursuit of a Portland, Oregon child serial killer, pushing C.W. to the brink of suicide.

A Seattle PD detective's investigation into a series of murders of women is aided by a call from an inmate at King County Jail.

John Cameron moves to Montana to start his career as a cop. When a child disappears, he is resolved to prove everyone wrong after the suspect is someone he knows. As John fights to clear her name, he digs into the world of a ritualistic child killer.