Ruby Gettinger, a lovable 487-pound woman from Savannah, Georgia, who has struggled with obesity her entire life. Ruby lives in a small two-bedroom house with her dogs, her nephew Jim and old friend Jeff. Together they share everything from laughs to a love of fattening Southern foods! But now Ruby's pals are realizing that they need to give her tough love in order to help her slim down.

After three months on a rigorous diet and exercise plan, Ruby is finally starting to see results and has already shed fifty pounds! Word of her weight loss has spread among friends and Ruby has recently been getting phone calls from her ex-boyfriend Denny who broke her heart six years ago when she was still struggling to lose weight.

Thanks to four months of strict diet and exercise, Ruby has lost 60 pounds! But she's growing sick and frustrated with her pre-packaged meals and she's feeling tempted to cheat on her diet, especially when she goes out to restaurants with her friends who gorge on pizza and other fattening foods right in front of her.

Ruby has become completely frustrated with her life, her diet and her training. She's hit a wall and is annoyed by everyone and everything! Although she has lost 60 pounds in almost four months, Ruby reveals she can't tell the difference in the mirror and it's making her unmotivated to continue losing weight.

California, here we come! Returning to Los Angeles where she lived for six years, Ruby must endure the challenges of travel for an obese person. Although she has lost over 65 pounds, she still has trouble fitting in the airplane seats and must put up with public humiliation in front of her friends.

Upon returning to Savannah from her trip to Los Angeles, Ruby is shocked to discover that she had gained back some of the seventy pounds she had lost over the last five months.

In a moment of triumph for Ruby, her weight dips below 400 pounds for the first time in years. While she is 70 pounds slimmer, Ruby's celebration is short-lived when she realizes that her support team can't agree on the best way to continue the plan.

After six months of dieting and exercise, Ruby is down 90 pounds and she's ready to show off her slimmer figure to the world. When her best friend Brittany Daniel comes to town, she wants to spoil Ruby and take her shopping to give her a hot new look.

Now that Ruby has regained some of her mobility, she's ready to accomplish her goals. After years of hiding out in her house, Ruby is ready to experience the big outdoors and convinces her best friends Jeff and Georgia to go camping. But first they've got to purchase the supplies!

It's been one year since Ruby started her weight loss journey and she's managed to shed more than 100 pounds. Now at 361 pounds, Ruby is one step closer to dipping under 350 pounds for the first time in her adult life.

Ruby is determined to dip under 350 pounds, and she knows that she needs to ramp up her exercise program if she's ever going to reach her goal weight. However, lately she has been feeling unmotivated by her trainer Reese and his monotonous workout plan. Ruby really wants to try more creative ways to work out, so she reaches out to Dr. Bradley who recommends she meet with Dr. Jackowski, a fitness guru.

Now that she is one hundred pounds lighter, Ruby is determined to reach her goals and she is eager to get back into the real world and find a part-time job for the first time in 10 years.

Ruby's weight-loss woes continue as she searches for a new trainer to help her reach a milestone weight of 350 pounds. But what will it take to help achieve what seems like an impossible task?

Now that she has fallen under 350 pounds, Ruby is ready to give her bedroom a makeover! She needs more room to move around and she's sick of dealing with all of her accumulating clutter.

During a pilates class, Ruby becomes emotionally overwhelmed when a flashback is triggered from her childhood. Her instructor explains that the mind and body share a powerful connection and old memories that are stored away can become activated unexpectedly.

The time has come for Ruby and her girlfriends' annual weekend getaway! This year, the ladies are heading to Tybee Island, a beach island off the Georgia coast, for some fun in the sun.

So far Ruby has lost 140 pounds! She's made a lot of progress, but she is still struggling with staying on her program. Lately, she has been lacking in journaling her food intake and skipping some of her workouts with her trainers.

Ruby becomes an emotional wreck when her beloved dog Lucy becomes gravely ill. Lucy's kidneys are failing her and Ruby must give her daily injections to help them function. Ruby feels herself wanting to turn to food to help comfort her during this difficult time, but she knows she must learn how to cope with the pain in other ways.

Still grieving over the death of her dog Lucy, Ruby is feeling unmotivated to work out and stick to her weight loss program. She knows she needs to get re-energized, so when Dr. Bradley suggests she visit a summer weight loss camp for kids, she agrees to go.

Ruby turns to a new therapist to help understand her recurring nightmares.

Ruby goes to Mississippi for a friend's birthday, but takes a detour to explore the missing memories of her childhood.

Ruby visits her ex Denny in Myrtle Beach for the weekend and wears a swimsuit for the first time.

Ruby encourages Christina to take part in the Plus Teen USA pageant and helps with her transformation.

Ruby spends a night in a sleep clinic and tracks down Dr. Dukes who helps shed light on her missing memories.

As Ruby struggles with losing weight, her therapist suggests she give up five unhealthy things from her life.