After Florida mother Gretchen Anthony, 51, goes missing from her home, surveillance video tells a twisted tale of her final hours.

A 41-year-old mother of three was brutally stabbed nearly 200 times in front of her two youngest children; investigators reveal a sick and twisted motive behind the deadly rampage, and her daughter who witnessed the attack speaks for the first time.

The bodies of two young women found dead in suitcases on the side of the road lead investigators to a former cop with a double life and a stunning confession.

Newlywed Lauren Phelps is stabbed 123 times as she fights for her life; her killer may blame his deadly rampage on cold medicine.

A romantic and scenic early morning boat ride turns deadly when Larry Isenberg falls overboard; investigators reveal the disappearance of half a million dollars, which could be motive for murder.

24-year-old Alex Woodworth is brutally stabbed 16 times and left for dead hanging halfway out of the killer's car; as investigators peel back the layers, it's revealed the killer's many lovers is motive for murder.