Sir Charles Baskerville is found dead on Dartmoor, with his face contorted in terror and the footprints of a huge dog near his body. On arrival in England, Sir Charles's American heir, now Sir Henry Baskerville, engages Holmes to come to Devon and get to the bottom of the age-old legend of the Hound of the Baskervilles - a phantom which kills.From the outset, Holmes is convinced there is a human murderer at work and he lays a deep plan to foil him.

The French government sends for Holmes when the Mona Lisa is stolen from the Louvre. Holmes swiftly decides he is dealing with a mastermind - and none other than his old enemy Professor Moriarty himself.Holmes foils Moriarty's plans to sell Leonardo da Vinci's masterpiece and trails him to Switzerland, where they meet and fight to the death above the famous waterfall at Reichenbach.

Holmes is approached by Helen Stoner, who feels threatened by her domineering step-father, Dr Grimesby Roylott. Her sister died mysteriously just before her planned wedding, and Helen has heard again the curious whistle she first heard on the night of her sister's death.Holmes perceives great danger and lays a complicated plan to defeat the threat to the beautiful Helen.

Colonel James Damery calls on Holmes when the rich and beautiful Miss Violet Merville announces her engagement to Baron Gruner, a dangerous Austrian. Gruner has persuaded Violet that he is not a killer, and Holmes has to establish the truth and foil the powerful baron.

A notice in a newspaper seeks red-headed men, inviting them to join a league which will pay them well - and Jabez Wilson, a pawnbroker who responds, finds he is hired and paid generously for spending four hours a day copying an encyclopedia in long hand. When the league is suddenly dissolved, Holmes is asked to find out what has been going on, and he quickly suspects crime. Indeed, behind this curious arrangement lurks Holmes's arch-enemy, Professor Moriarty.

A young solicitor, John Hector McFarlane, seeks Holmes's help after retired builder Jonas Oldacre dies in a fire. McFarlane, who benefits from Oldacre's will, is suspected of murder and asks Holmes to clear his name. Holmes looks for another motive and another killer, and dresses up as a tramp to get the information he needs about the Oldacre household. The surprising answer he finds is that Oldacre is not exactly dead.

Holmes is asked by the country's Prime Minister to aid in the recovery of a stolen diplomatic letter, which, if published, might lead England into war.

Dr Trevelyan calls on Holmes on behalf of his friend Blessington, after a Russian father and son vanish during a consultation. Blessington knows of no one who wishes him ill, but he is found hanged the next day. Holmes investigates, with advice from Watson.

Hilton Cubitt, from Derbyshire, consults Holmes about a series of dancing men picture-messages his wife is receiving. On their wedding-day, she had made Cubitt promise he would ask her nothing about her past, but she now seems to be terrified. Holmes has to decipher the code of the matchstick men and get to the bottom of a dreadful murder which lies behind it.

The body of one Cadogan West is found in an underground tunnel near Aldgate Station, with his skull smashed, and Holmes is puzzled by the interest his brother Mycroft is showing in the case. Mycroft explains that the top secret plans for a new submarine were in the dead man's pocket, but three of the ten pages were missing when the body was found. Mycroft, on behalf of the British Government, asks his brother to find the missing pages.

A plumber, John Horner, is arrested just before Christmas and charged with stealing a famous jewel, the Blue Carbuncle, from Lady Morcar. He denies the theft - but he has a criminal record, and all the evidence is against him. After Holmes's doorman finds the Carbuncle in a Christmas goose, Holmes uses an old hat to track the goose to a poultry dealer, then traps the servant who stole the jewel and framed the plumber. The Blue Carbuncle has a dark history, and the stone features in the programme's opening credits with turbulent scenes from its past.

Sir Robert Norberton stakes a huge amount (much of it borrrowed) on his horse Shoscombe Prince winning a race. His trainer thinks Sir Robert has gone mad and consults Holmes. Then one of the many creditors disappears and human bone is found in a furnace...

In a remote area of Dartmoor, The Silver Blaze, England's most famous and valuable racehorse, goes missing, the dead body of the horse's trainer is found, and sheep are savaged. The Police seem bewildered, but then they charge Fitzroy Stephen, a famous figure in the racing world, with the murder. Holmes is called in to trace the missing horse and finds he has to separate fact from fiction.

A man dies suddenly of a mysterious fever, and Holmes suspects murder.

A masked man calls, on confidential business, and Holmes quickly recognizes the visitor as the King of Bohemia. The King is planning for himself a dynastic marriage and is worried about a compromising photograph in the possession of his American former mistress. He wants Holmes to get it back for him.In outwitting the lady, Irene Adler, Holmes goes to great lengths - and at the end of the affair Watson comes to the conclusion that his friend is himself smitten.

Holmes is approached by Percy Phelps, of the Foreign Office, to recover a document which has been stolen - before it can cause an international scandal and ruin Phelps's career. It seems the British Empire and the Kingdom of Italy have entered into a secret and embarrassing treaty.

Violet Smith has recently started a new job as music teacher to Robert Carruthers, staying during the week at his house in the country. She consults Holmes because she is worried about being followed once a week on her way to the railway station by a man on a bicycle. Carruthers asks Miss Smith to marry him, but Holmes sees a sinister connection between him and the stalker.

An unhappy wife learns that her husband, Colonel Barclay, cheated her earlier fiance, leaving him disabled and in exile. After a fierce argument between them, the Colonel's dead body is found next to his unconscious wife in a locked room with no key, and with curious animal tracks outside the window. Nancy Barclay remains in a coma.Holmes investigates and finds a story of betrayal and a mystery worthy of his powers.

The daughter of scientist Professor Presbury sees her father's face at her second-storey window; Holmes connects this with recent zoo thefts.

Holmes and Watson attempt to thwart the schemes of the infamous blackmailer Charles Augustus Milverton from blackmailing Lady Eva Blackwell. But things do not seem as easy as they do and Holmes must sacrifice his morality and his honourable career to stop Milverton from wrecking her marriage.

American heiress Henrietta Doran (known as Hatty) marries Lord St Simon, but she vanishes without trace on her wedding day, leaving London agog. Later, the police find her wedding dress in the Serpentine, a lake in a London park, with a note in the pocket of the dress. While investigating the case, Holmes suffers from nightmares, which he sees as a factor in the mystery.

Maria Gibson, the wife of a gold-mining millionaire, is found shot dead at their country house. Gibson asks Holmes to find his wife's killer and thus to clear the name of his children's governess, Miss Dunbar, who has been charged with the crime. Is Gibson acting as a kindly employer, and what are the hidden depths of the case?

Alice Turner sends for Holmes when her lifelong friend farmer William McCarthy is killed and police suspicion falls on his son, James. James McCarthy admits quarrelling with his father, but he will not explain what their argument was about.

Holmes is curious about a series of attacks on figures of the French Emperor Napoleon Bonaparte around London. One such incident leads to a violent death, and he investigates. Lestrade sees an Italian connection and proposes to focus Scotland Yard's attention on the Italian quarter of London, but Holmes is more interested in Chiswick.

Violet Hunter consults Holmes about Edward Rucastle's offer of a job. He wants her to cut off her hair before coming to work for him as a governess. Holmes sees a sinister motive and investigates.