A holodisc containing a security code is stolen from an intelligence agent named Mark Trenton. Holmes is brought in by the intelligence agency to find the disc. Trenton's wife and another agent named Edward Lucas appear to be connected to the case.

During a car chase, their quarry vanishes. Then our heroes get a call that a wealthy man's car (The Napoleon) was broken into and vandalized. Not stolen, and precious gems are ruined nearby.

To prevent Inspector Lestrade's dangerous antics and police chases, Grayson has assigned her a new partner ""fresh out of the academy."" As the Scotland Yard's security becomes compromised, the rookie keeps bumbling, making mistakes and getting in everyone's way. Is he really what he seems to be?

Inspector Lestrade learns Alice Murphy is engaged to their old teacher, Prof. Jacob Presbury. The professor is moody and forgetful. His daughter is jealous. Family friend Trevor is over-protective. Meanwhile Holmes investigates three monkeys stolen from the Primate Shelter, stolen as it turns out by Trevor who wants Alice for himself and so turned Presbury into an apeman.

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A man receives five orange seeds, or pips in a letter, but they have been tainted with some kind of serum that induces a coma in him. Before succumbing, he writes down an address and gives his son these instructions. Get help from Sherlock Holmes, and under no circumstances is he to be brought to a hospital. Complicating matters, is the family are ""anti-techs,"" people who are strongly against tecnology and robots of any kind, preferring to live in Sherlock's time period. Watson is not exactly welcome...

The pilot tells how Holmes survived in and came to be revived in the Holmes Museum. He anticipated two centuries' progress in cryogenics, preserving himself -- in honey! The criminal activity of Moriarty's clone prompts Inspector Lestrad, like her ancestor, to seek Holmes' help. Her compudroid so loves the Canon of Sherlock Holmes stories that it assumes the name and role of Dr. Watson.

Moriarty and Fenwick steal the Mazarin Chip, a microchip which can be used to create virtual environments instantly, and kidnap the Prime Minister. Holmes uses a waxwork likeness of himself to catch Moriarty in a trap.

Holmes fakes madness and babbles about oysters apparently after exposure to a boobytrapped puzzlebox, not infected with mind-altering nanobots. At Midgard Hospital are the suspected nanatech thieves: Dr. Cushing, Dr. Cuthbertson Smith and Dr. Chang. Smith is given away by the surgeons' knot on his retro nonvelcro shoes.

A mysterious and somewhat theatrical vampire is crashing computer grids, swimping codes, invading locked vaults, and causing panic in New London. The only clue is video images of the devil grinning into the camera as he crushes a computer disk in his hand. Lestrade pursues the Sussex vampire with her usual (destructive) aplomb, which rather amuses the detective. Diedre--who has a unique female perspective on things that Holmes cannot for all his smarts manufacture--notes an interesting quirk their foe has while watching hours of old vamp flicks and tapes of the Sussex vamp's little disk-breaking show. Holmes, Watson, and the Baker St. Irregulars pursue the data-sucking fiend into its sewer lair...and meet up with an old ""friend"" of Holmes', who is also looking into the vamp matter.

Mary Morstan comes to Holmes with a problem. The solution of that problem, however, will lead them clear to the moon! Mary's father had been killed in a mine accident on the moon years ago. Now Mary is finding out that the circumstances were strange then, and the sequel is even stranger now.

The ancient Musgrave sword is stolen from the heavily-guarded museum even though the inscription on it is readily available on the replicas in the souvenir stand. The trail leads to the Musgrave graveyard and on into ""the Abyss"".

Henry Baker loses hat and doll, a GREEN Carbuncle rather than the usual blue one from the Wundygate toy store. It is actually a prototype robot with a human-like personality. Naturally Moriarity wants it. Holmes lets him have it!

Fenwick and Moriarty's other henchmen assume disguises, using technology invented by Dr. Blessington to make their DNA unrecognizable.

A giant hound has been seen-and strangely enough, heard- on the moon. People are worried. It's up to Holmes, Watson, and Lestrade to expose what's happening and to catch who's responsible for it all. Of course, being jumped by the hound along the way doesn't help matters...

A loud argument between a man and his wife attracts the attention of their housekeeper. The man is then discovered to be missing. The room shows signs of a great struggle, with curious parallel slashes everywhere. It also seems that a great change has come over the wife since her walk that afternoon. Holmes is determined to find out what happened on that walk. The result is amazing.

This story introduces Martin Fenwick, who like Dr. Frankenstein is overwhelmed by his creation, a Moriarty clone and the 22nd century Baker Street Irregulars -- as always street-wise young people -- anti-grav chaired computer whiz Tennison, a Black would-be boxer Wiggins and a girl, Deidre.

Dr. Grimsby Roylott uses a snake, not to kill his daughter, but to become a snake-man to steal nanobot technology to save his failed New London Zoo. The clues are a snake scale with hair, a sabotaged hovercraft, the Zoo financial records and the history of the animal rights activists, the Earth Sentinels.

Lois St. Clair asks Holmes to find her husband Neville. The investigation leads to a panhandler with a twisted lip.

A blood regenerating device is stolen from the safe of a scientist named Victor Hatherley. Hatherley's thumbprint is needed to open the safe.

Inspired by ""His Last Bow"" A robbery at 10 Downing Street threatens the very existence of England itself. A thief steals data plans of the ultimate security system out of a secret safe hidden in a high light fixture, replacing them with a copy. When he accidently sets off the alarm, he steals an African doll to use as a decoy burglary.

The racing vehicle Silver Blaze is missing. Now the owner blames his rival, who blames him back. Holmes must figure out how to get information out of the only one who witnessed the crime: the owner's dog, who barks loudly if anyone unfamiliar comes near. The ending will have Lestrade at the wheel as they fly through asteroids to catch the culprit.

Holmes' friend Victor's father is apparently being blackmailed. Ever since the appearance of Hudson, a new hiree, he has seemed edgy, and mysterious notes have been found. But how far back will this case take our heroes? Holmes' must unravel events from before Victor's birth in order to solve this case, including why Mr. Trevor is using an alias.

The Beryl Board, a new computer processor, has been stolen from the home of Mr. Holder. Holder accuses his son, Arthur of stealing the board, which was found in his possession with apiece broken off. It is up to Holmes, Watson, and the Baker Street Irregulars to clear Arthur, and to expose the one he has been hiding.

Carter Wilson is tricked by Vince Spaulding into working for the Red Headed League.