Lana joins a sorority to get housing for her last-minute college registration, but the sisters have a deadly agenda which involves turning Lana into a vampire like themselves and sending her against Clark. Meanwhile, Chloe applies to become an intern at the Daily Planet and runs up against the editor-in-chief, Pauline Kahn.

An illegal immigrant comes to Clark for help, escaping from a nearby farm where he's working... a farm that houses a dark secret.

Clark gets into a class election and one of his opponents is a krypto-mutant who can control bees. Meanwhile a reporter from Metropolis visits to do a story on Lex.

Martha's father William comes to town after many years of estrangement due do his disapproval of Jonathan. Meanwhile Clark must deal with a series of old-age deaths at Smallville High, and the new principal puts his foot down.

Clark is suspicious when Lana suddenly becomes attracted to a fellow student and begins to act rebelliously, which eventually lands her in jail. Clark's suspicions are confirmed when he discovers Lana's new boyfriend has magnetic powers that can move objects and alter human emotions, but when he tries to free Lana from the paranormal hold that is controlling her, she tries to kill him. Meanwhile, Lex discovers Chloe has been delving into Lionel's past and tries to get her to join forces against his dad.

Chloe is possessed by the spirit of a young girl whose body is sealed in the Talon's walls, and goes searching for the girl's killer while Clark and Lois try to track her down.

Pete Ross returns to town and finds a number of surprising changes since his departure. Besides resolving his feelings toward Clark since he learned of his friend's secret, Pete has to deal with the acquisition of a superpower of his own.

A weight-obsessed teen dieting on kryptonite-infected vegetables gains her fondest dream...but must feed on the fat of others to maintain her enhanced appearance.

Tyler gains the power to destroy organic matter with a touch, and resolves to put the dying out of their misery...and Whitney's father is his next target. Meanwhile Lionel and Lex spar over Lionel's rising success in Smallville.

After Pete refuses to throw a street race, the thugs that run it threaten his life, so he asks Clark to use his powers to stop them. Furious that Pete would put himself in this position, Clark must figure out a way to save Pete and still protect his secret. Meanwhile, Jonathan begins to suffer the consequences of his deal with Jor-El.

Checking out a crater in a cornfield, Clark and Lana discover a baby with no parents and take him back to the Kent farm. However, when the baby, Evan, ages from a newborn to a 7-year-old in less than a day, it becomes clear he is aging at a rapid rate and they turn to Lex for help. Meanwhile, Genevieve suspects Lex has the Chinese Kryptonian artifact and orders Lionel to either recover it...or risk putting Lex in danger of his life.

Lana and Lionel have a secret meeting, after which Lana is shot. While Jimmy is observing photos of the encounter, he is knocked unconscious. While unconscious Jimmy dreams about what life in Smallville would have been like in the 1940s. Clark is a reporter at the Daily Planet, Lana is a siren who planned the demise of her magnate husband Lex, and Lois is a singer at a bar that Lionel owns.

Clark discovers that Lana is missing; Tess reveals what really happened to Lana when she woke up from her Brainiac-induced coma; Tess is shocked by what she discovers in a secret LuthorCorp facility.

Clark must deal with Greg, a nerdish bug collector with a crush on Lana who gains the ability of various insects and uses them to lash out at anyone who opposes him.

An abusive and hot-tempered football coach gains the ability to control and project fire.

A jock named Sean gains the ability to absorb heat from everything and everyone around him, and begins preying on people to gain the heat he needs to survive.

Lex and Victoria are victims of a suspected household poltergeist. As the disturbances become more violent, suspicion lands on Amy, the daughter of a house servant who is obsessed with Lex. Not is all as it seems...

Whitney falls in with some former jocks who have kryptonite tattoos that give them the power to walk through walls. Meanwhile, Chloe is seriously injured and Lex has his own plans.

Lana has a new stalker - a boy imprisoned in his basement by his parents who sneaks out at night to visit her. Meanwhile Lionel hires Clark's mother as his personal assistant.

Distraught over her break-up with Clark, Lana goes to a rogue medical student who experiments with a dangerous kryptonite-based serum that allows people to flat-line but see their dead loved ones. Lana attempts to see her dead parents using the serum and when Clark returns from Honduras to help her, the doctor injects him with the serum and Clark speaks with his dead father...who warns him that Lionel knows his secret. Meanwhile, Lionel continues working to get closer to Martha, and Lex has a near-death vision of his mother.

One of the escapees from the Phantom Zone has killed the crew of a ship in Seattle. Clark confronts the killer who feeds on the bones of his victim. In Smallville, a patient in LuthorCorp Labs escapes experimentation and seeks revenge on Lex by trapping him in a dimension where he can see and hear those around him, but they cannot see him.

Lana has a stalker which leads her to an unexpected hideout. Also, Chloe has to reevaluate her feelings for Clark after she and Jimmy break up due to Jimmy's belief that she isn't really over Clark.

While Clark seeks out Brainiac to force him to fulfill his side of their bargain and restore Lana, Chloe and Jimmy go up against the government.

Clark runs up against super-strong robbers who are apparently tied to LexCorp. And Chloe begins to ally with Lionel, while Lana and Henry Small bond.

While his father is awaiting surgery, Clark befriends a young boy, Garrett whose brother Vince just died from liver failure. However, everyone is shocked when Vince shows up alive and seemingly well - until his liver starts failing again. In a desperate attempt to keep his brother alive, Garrett straps a Kryptonite bomb to himself and demands that Vince be given Jonathan's liver or he will blow up the building.