On a night out in Doncaster - once crowned HIV Capital of the North - Stephen Fry chats to young people about current attitudes to HIV and risky sex. He also visits his first love from Cambridge who later found out he and his new partner were positive. And he meets an HIV-positive grandmother, and a 16-year-old girl who has lived with the virus all her life.

Stephen Fry explores the impact of modern treatments and visits Uganda to investigate why drugs are unavailable there. He also takes an HIV test himself, and wonders why so many others are reluctant to do the same. His conclusion is that, while things have improved medically, the situation seems worse than ever psychologically and socially.