A patient of Dana's gives birth to twins — one baby is black, the other is white. And Lu suspects that a woman with chronic back pain is addicted to prescription drugs.

The Rittenhouse doctors cope with a blood shortage in Philadelphia. Dana helps a patient who unknowingly contracted hepatitis from her husband, and Lu deals with a family of illegal dog fighters who have Lyme disease.

Andy goes beyond the call of duty to expedite the Food and Drug Administration's approval of a drug that could help Robert's wife, who has multiple sclerosis. Also, Andy intervenes when a family is accused of endangering the life of their young daughter. Meanwhile, a woman with terminal lung cancer claims to be Lu's half-sister.

When an old colleague with a breast lump calls for Andy's help—from space, of all places—the former Army colonel is at full attention. At the speed of light, she mobilizes both her hospital and NASA troops to perform a biopsy and, eventually, the removal of a growth. Back on Earth, Lu tries to help a pregnant woman with breast cancer make the delivery of her child—and the removal of the tumor—the happiest day of her life.

Strange things are brewing at Rittenhouse. A patient seeks Lu's treatment for what appears to be a simple rash; but upon closer examination, the condition turns out to be a dangerous flesh-eating bacteria. Meanwhile, Andy is caught in the middle of a sensitive case when a mother wants to have her schizophrenic daughter's tubes tied. And Peter tries to piece together clues to close the book on a doc who's up to something sneaky.

Lu faces the horrifying memory of her rape when a patient turns to her for help in dealing with her brother, a convicted sex offender. When Andy's patient displays baffling, life-threatening symptoms, Andy suspects foul play.

Academy Award-winning actress Rita Moreno guest stars in this episode of ""Strong Medicine,"" airing March 9, 2003 on LIFETIME Television. Moreno plays a street doctor treating patients who don't have the financial means to obtain medical treatment. Dr. Delgado makes a point of checking on her when she suspects the doctor may be growing senile. Later, Lu becomes frantic when she learns that a building has collapsed and her fire fighting boyfriend is unaccounted for while Andy counsels parents who are forced to make an extremely difficult medical decision about which of their two children should have lifesaving surgery

Andy and Milo treat a woman with an enlarged heart and conflict about what surgery to perform on her. Lu gets angry with Marc after he stays out until after midnight and insists that she babysit him until he is more responsible. Andy tells a sexually active elderly woman that she has HIV. Lu finds out about a terrible hospital error when trying to find a matching bone marrow for a young leukemia patient. Lana and Peter search the inner city for a woman whose aorta could burst at any time and face some frustrating difficulties.

Lu deals with the schizophrenic mother who takes her five year old girl who suffers from epilepsy off of her medications in favor of a ""ketogenic diet"" which has stopped all the seizures. Additionally, Andy and Lu have a friendly competition when each one of their patients is studying for a spelling bee. Andy also has to adjust to spending her first Christmas holiday without the kids.

Andy is considered for the prominent Chief of Surgery position (after the current Chief retires) and discovers a competitor bribing members of the board which is going to decide on a replacement. In the midst of this, she must decide whether or not to perform a potentially career-hurting dangerous surgery on a pregnant woman run over by an SUV driver talking on their cell phone. Meanwhile, Lu battles a company that wants to take her financially-deprived patient's cells to find a cure for leukemia without paying her. Also, Lana finds romance over dog residue.

With Christmas only a few days away, Lana goes on a frenzy decorating the clinic and organizing a Secret Santa gift exchange. However, when a plan to set up Peter and Kayla backfires, she has a lot of explaining to do. Meanwhile, Lu delivers a virgin surrogate mother's baby but when the parents find out something about the baby, they do the unthinkable. Also, Andy must find a young girl who may die if she doesn't get treated for a deadly disease she may have.

Lana finds a crafty way to help one of Lu's patients, a construction worker with a brain tumor, raise enough money for a necessary surgery. Andy treats a woman who needs to have surgery to save her life. However, the woman refuses to have the surgery performed until she meets her first grandchild, who is about to be born in Paris. Peter tries to find the father of a patient's child.

In a special episode of Strong Medicine, the Rittenhouse Hospital Emergency Medical Services team is introduced. EMTs Kate and Zach are attacked while trying to save a young girl's life, figure out the motive behind it, and reach a dubious resolution. Then, a multiple vehicle accident keeps them and Dr. Vanessa Burke, an African American trauma surgeon and Katie's adoptive sister, busy. A chemical spill threatens the lives of those in the accident and a guilty driver makes an impulsive decision. Meanwhile, a pre-teen in the accident needs a transplant and Katie and Lu search homeless shelters for a match. Even after they find one, they still face some difficulties. Vanessa amputates the legs of a man who begged her to let him die and must convince him that life without legs is still worth living.

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When a patient of Andy's takes a turn for the worse under Lu's watchful eye, the two doctors butt heads over whether proper procedure was followed. Meanwhile, Andy questions whether or not she can trust her oldest daughter. Also, when Andy and Morton try an experimental xenotransplant (using the heart of a chimpanzee), Peter questions the rights of the animal.

Dana is troubled when a patient requests new breast implants immediately after her first ones rupture. Elsewhere, Lu fears for the life of a wanted criminal's sickly newborn.

Andy returns to the Army for reserve duty and helps a woman with post polio syndrome (PPS). Sparks fly for Lu when she is reunited with an old friend whose mother is one of her patients. And when Lana asks if the guy was the ""first"" one Lu answers saying he was the only one.

When Andy encounters a young woman with amnesia and her fiance, she must decide which secrets should remain untold. Meanwhile, when a pregnant patient refuses to stop using drugs, Lu faces an ethical dilemma and must decide whether to intervene.

It's Breast Cancer Awareness Weekend at the Rittenhouse Hospital Women's Clinic, where Lu (Rosa Blasi), Lana (Jenifer Lewis) and Peter (Josh Coxx) are hosting a dance-a-thon and a free mammogram clinic. When one woman's mammogram reveals a lump, she must choose between losing both her breasts and losing her job. After Dana (Janine Turner) delivers the unexpected results of her breast cancer clinical trial, she learns the very disease that's defined her career has now hit too close to home.

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