Sam and his rock band, Team Samurai, are on the bill to perform at a concert at North Valley High School tonight, but Malcolm has other ideas. He creates the Trembulor virus to create an impenetrable barrier around Sam's house.

A fortune-telling game is the culprit in this episode, as once infected by a virus, it causes everyone's personalities to completely reverse. From this spell, Sam becomes a wimp, Tanker becomes a nerd, Amp becomes really really smart, and Sydney....well, you can just call her Wild Thing!

Tanker & Jennifer are cast as Romeo and Juliet in the school play, much to Sam's and Sydney's dismay. Malcolm revamps the Chronic virus and sends him into the school's stage lights.

Malcolm uses the Skorn virus in order to win the student body presidential election over Yolanda Pratchert.

A virus is sent into Jennifer's pager, which causes Jennifer to dislike Sam and love Malcolm.

A virus is created that causes everyone affected to forget everything - even who they are.

Amp falls in love with his substitute history teacher, Ms. Tilden. After mistaking an utterly hideous old woman to be the object of their friend's affections, Sam, Sydney, and Tanker institute a scheme to make him forget his crush. Also, Malcolm has a totally unrelated nefarious scheme of some sort. :oP

Malcolm creates the Blink virus and sends it into the police files in order to cause a false arrest for Jennifer during her date with Sam at the drive-thru theatre.

Sam decides to have a slumber party at North Valley High School as the school's fundraiser. However, Malcolm sends the fire virus, Plexton, into the school's thermostat. With the party literally boiling over in the intense heat, can Servo save the day?

The battle begins in this episode when Sam Collins, your typical high school student, discovers the world of Syberspace and becomes Servo, fighter for justice in the digital world.

After earning a 'B' on her report card, Sydney finds that this is the least of her worries when a Mega-Virus takes over her wristwatch and makes her hand go on a petty crime spree.

Malcolm sends the Skorn virus into Sydney's voice synthesizer, which then totally messes up Tanker's and her voices.

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Kilokahn decides to experiment on himself by taking over Malcolm's body in order to experience life in the real world. He then sticks Malcolm inside of a new mega-virus monster. Sam and the others notice that it really is Kilokahn inside Malcolm's body (while he tries to cover it up to the rest of the outside world), and it is up to Servo to save Malcolm.

Malcolm creates the ice virus known as Gramm (sister to the fire virus, Plexton) and sends it into Sam's air conditioner for the purpose of having people turning cold against one another. Surely enough, it works on its victims - Sydney, Tanker and Amp. Sam, as Servo, must destroy Gramm in order to break the spell (and in the process, fend off the reserve virus, which is none other than Plexton!).

Malcolm creates the Hock mega-virus monster and sends him into the food factories for the purpose of stopping shipments of food to the world that needs it.

Using the Troid virus which has been sent into Jennifer's pom-poms, Malcolm is able to make the world around Sam disappear completely when each victim picks up the pom-poms, and the victims end up in syberspace, stored onto floppy disks! Sam is the only person he knows that is left, and comes to the realization that the virus is responsible for the disappearance of everyone he knows.

Sam learns just how dependent he is upon his friends when he gets sucked into a video camera and nearly goes insane from the prolonged enforced solitude.

Sydney installs a children's computer program and is able to use it on Kilokahn, turning him from evil to good. When Malcolm discovers the good Kilokahn (and the fact that the good Kilokahn will not bring the Hock virus to life), he is infuriated and attempts to take on life as a good-natured fellow, only to fail miserably.

After Sam has a strange nightmare, Kilokahn seizes this opportunity to send a virus into Sam's alarm clock which freezes it and gives Sam continuous nightmares. How will Sam ever wake up to actually defeat the virus?

In order to make Sam miss a date with Jennifer, Malcolm creates a Mega-Virus that will render time meaningless around the world.

Malcolm taps into bank accounts across the country, making him incredibly rich while everyone else struggles to pay for necessities. Of course, he uses his money to bribe his schoolmates into doing embarrassing things. Sam holds himself aloof from this until his little sister, Elizabeth, gets into a car accident and needs surgery.

Upon having his act for the school talent show, a dramatic reading of Coleridge's ""The Rime of the Ancient Mariner,"" shunned, Malcolm decides upon the somewhat thematic revenge of turning all the water in the city into hydrochloric acid. Also, Tanker learns the danger of bingeing on dill pickles, and spends the episode in agony from severe stomach pain, and learns an important lesson about where his limits lie.

Desperate to prove to Jennifer that he is not totally lacking in any sense of romance, Sam plans a romantic dinner for the two of them. However, when he lets Tanker, Sydney, Amp, and Mrs. Starkey help him out, Malcolm overhears and uses this to his best advantage by sending a Mega-Virus Monster into Mrs. Starkey's egg-timer to make her go insane.

Sam's report for school is destroyed by Elizabeth, who draws pictures all over it, and Sam feels he is about to face impending doom at school because of this. But that is the least of his worries when Kilokahn, against Malcolm's wishes, releases a mega-virus monster to sound off an alarm system which will apparently trigger warheads throughout the globe. It's up to Sam once again to save the world from certain danger!