Sam and Dean learn about a monster killing in Chicago and head there to investigate. What they find is a young cop whose girlfriend was killed by the same creature, and who is caught between five powerful clans of monsters who jointly control the city.

After a construction worker is killed by insects burrowing into his brain, Sam and Dean investigate the town's history and find that the new housing development is being built on sacred Indian land. The Indians put a curse on the land after their reservation had been ravished and destroyed. Sam and Dean must find a way to survive and kill the deadly swarm of bees, locusts, spiders and beetles.

It's the final ride for the Winchesters saving people and hunting things.

Sam and Dean investigate a bizarre murder in a college town. Close on the tail of their suspect, they bust into an apartment to find two dead bodies and a laptop cued up to some disturbing video footage.

Sam and Dean investigate a series of werewolf attacks.

A police officer named James, who turned to witchcraft after working a case with Sam and Dean, is plagued by nightmares in which he murders innocent people.

The Winchester brothers investigate a murder that was apparently caused by a ghost. Sam and Dean discover that the Ghostfacers, Ed and Harry, are already on the case.

A ghost starts killing people through various electronic devices. Sam and Dean discover who was killed and why this ghost is seeking revenge on a group of college students but what they can't figure out is how he’s doing it. With three dead, the brothers must stop the ghost before he claims his next victim.

Sam and Dean investigate a string of suicides committed by people with little in common other than the identical, grisly method of death – slow, self-administered disembowlment. All of the victims were members of a Catholic church and had recently given confession, leading the brothers to suspect the priest is somehow involved. Meanwhile, when Crowley captures Olivette, the leader of the Grand Coven, Rowena pleads her case to be allowed to practice magic freely again.

Sam and Dean are alarmed when they learn hunters are being killed by suspicious “accidents” all over the country. They decide it is best to find Mary and make sure she’s safe. Meanwhile, Toni is back in the states and she and Mary face off.

Sam and Dean are asked to investigate the murder of a childhood friend, calling them back to a motel from their past and perplexing the brothers with a case they thought was solved a long time ago.

Dean is contacted by his first love Cassie, an African-America girl, who asks him to come to Mississippi to investigate a string of racially motivated murders. Each murder is linked to a mysterious truck that seems to have no driver and leave no tracks. Sam is stunned to see this new side of his brother as Dean struggles to come to grips with the residual feelings he has for Cassie.

Sam and Dean investigate some recent vampire kills and are surprised to learn Krissy Chambers is involved. They find Krissy and learn her father was killed and she’s been taken in by a man named Victor, who has taken in a group of orphan kids to teach them how to hunt.

Sam, Dean and Castiel call on Rowena to help keep the evil souls at bay and get an unexpected assist from Ketch.

Sam and Dean respond to a frantic call and together along with Castiel, Jack and Jody, assist in an extraordinary and heartbreaking rescue. Billie surprises everyone with a visit to the bunker.

Ben calls Dean and tells him Lisa is in trouble. Dean leaves Sam to investigate a case alone and rushes home to rescue Lisa, however, he’s not prepared for what meets him at the door. Meanwhile, Sam discovers the men that were murdered were all a part of a cruel practical joke played on a female co-worker who went missing.

Six months after his disappearance, Garth turns up injured in a hospital. Sam and Dean arrive separately to investigate and soon discover that their friend has undergone a startling transformation.

After learning that the soul of Adolf Hitler has been trapped in a 1930’s gold pocket watch, Sam and Dean must act quickly to prevent a group of Nazi necromancers from resurrecting the Führer.

Sam and Dean investigate a string of unusual murders where the victims were all recipients of organs from the same donor. The killer is captured, but things become even more complicated when the brothers find their killer in a trance mumbling an ancient prayer.

Sheriff Jody Mills befriends a young girl on the run from vampires. When she's forced to kill one of the monsters, Jody calls in Sam and Dean for help. However, they discover that everything isn't at it seems.

Dean and Sam investigate a bizarre murder and realize the killer bears the same tattoo as those from the Styne family. Meanwhile, Castiel acts as referee when Charlie and Rowena are forced to work together on the Book of the Damned. When Crowley discovers that his mother is missing, he turns to an old enemy for help.

In a small town in Colorado, mysterious disappearances happen every 27 years. Sam and Dean head to the town to investigate and meet two hunters who have a personal vendetta against these once-in-a-generation monsters.

Lucifer realizes that as rock star Vince Vincente, he can get his fans to do whatever he wants. Thrilled with this power, Lucifer arranges to play a secret VIP concert in order to kill all of them. Sam, Dean and Castiel enter the underbelly of the music industry to try to stop him.

Castiel and Jack work a case involving members of a local church. Meanwhile, Sam and Dean go off in search of Amara.

In a change of pace, Sam and Dean decide to star in a violent, profane reality show named Ghostfacers. The show takes them to the haunted Morton Mansion, and they soon realize they're in over their heads.