When Count Venamus returns with a giant robot, and a plan to use a virus pod meteor shower to infect the planet, the Noobs turn the Galacticus into a giant robot to stop him.

The Noobs attempt to prove that they are responsible by babysitting for a couple who have just moved into the neighborhood, which becomes more difficult when the baby drinks a bottle infected with the virus.

The Noobs discover that they can turn their battleballs into whatever they desire.

The Noobs decide to see who's the best of the group by competing in a series of events in the first ever "Supernoob Super Cup".

The Noobs discover that Mem and Zen have the power to transform themselves into people and imitate their voices. Tyler goes on a date with Amy Anderson to the new smoothie shop when an active yogurt culture smoothie becomes infected with the virus.

Mem and Zen pose as the Noobs' parents during parent-teacher conferences at school.

The Noobs attempt to use their powers to penetrate the incredibly long line for a new video game.

A new strain, called the elimination virus is discovered that has the ability to infect a human without changing their appearance. In an attempt to destroy the Noobs, the virus infects the glee club and they must battle them in a sing and dance off in front of the whole school.

Shope's parents are concerned about her performance in school and feel that the boys are bad influence. The Noobs sneak into the Galacticus cloaking room where the energy is transferred to Shope, making her invisible instead of the Galacticus. The boys have to keep Shope out of trouble until Mem and Zen can make her visible again.

Mem and Zen try to make the Noobs seem like great warriors when they discover they will be featured on the intergalactic reality show "Extreme Virus Warriors".

The Noobs training continues as they learn new ways to use their powers to defeat the virus. Realizing that they could use their powers to also defeat their schools arch rivals, the Eastside Wolves, the Noobs join the football team and are faced with a moral dilemma of getting caught.

The Noobs turn to Mem and Zen to help them prepare for the upcoming school dance where a fire virus turns students into fire breathing dragons. In an effort to get closer to Amy, Tyler's plan to save her in his Supernoobs costume backfires when she falls for the super hero version of himself instead.

During rehearsal for the school play where Roach plays a rocket, his battleball becomes activated by his love for the drama coach making him shoot off like a real rocket. Fearful that he will be mistaken for a real missile and shot down the Noobs must find a way to rescue him and bring him back down to Earth.

Mem and Zen take the Noobs to space for the New Virus Warrior Convention and Recruiters Awards where they are not taken seriously and spend the time in their hotel room instead. Meanwhile at the Awards Ceremony, Count Venamus is set on spreading the virus to all the new recruits leaving only the Noobs uninfected to battle the virus.

Kevin transforms into a cat and gets stuck in a tree until a teen boy rescues him and receives a reward from the city, leading the Noobs to attempt to get the same.

Roach begins to feel that the other Noobs are taking advantage of him, so when a rare bird is infected by the virus on a field trip, he decides to let the others handle it without him.

Nervous that the virus could attack at any minute Kevin insists on wearing his battleball in school when it malfunctions and he gets stuck as a dog. Upon getting caught by the dog catcher and thrown in the pound the virus begins to infect the stray animals. The Noobs must find a way to free him from the pound before he is stuck that way forever while battling the Virus.

The Noobs travel to an alien zoo with Mem and Zen, only to be captured and put into a exhibit by the zoo's owner.

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The Noobs pilot the Galacticus into space to get medicine for Mem and Zen's infected eyes, and end up helping a space princess overthrow an evil dictator.

The pressures of living together finally push Mem and Zen to the breaking point, causing them both to move out, and into the homes of the Noobs, who quickly grow tired of them and scheme to get the two back together.

Mem and Zen decide to become directors and create a TV show based on their adventures with the Noobs

The Noobs compete against each other in the school science fair, but problems arise when several of the projects are infected by the virus.

Roach's battleball malfunctions, transforming him into an evil super villain bent on dominating the Earth

When Tyler and Shope's guinea pig escapes from home ec class Kevin has to become a guinea pig to sit in while Tyler searches for the real one. Tyler and Roach then discover a virus that recently landed only to find the guinea pig has eaten several of them. Now they must conquer the virus beats and get the guinea pig back in its cage before the end of class.