Three years have passed from the Nihonbashi incident. Jinya hears talk of street killings occurring near a soba shop. The number of dead don't match the number of missing.

Jinta changes his name to Jinya and departs Kadono. Ten years pass and he is now a ronin living in Edo, well-known by the locals as "the demon slayer."

In the fall of 1853, a samurai by the name of Naotsugu Miura grows concerned about his missing brother. However, everyone insists that he doesn't have a brother.

In the winter of 1853, Jinya is hired by Jyuuzou to investigate a demonic painting known as "the Ukiyo-e of Kudanzaka" that's said to be cursed.

Jinya and Natsu get attacked by the slasher thought to be a demon. After Mosuke arrives to help and Jinya brandishes his blade, the demon quickly vanishes into the darkness.

It is 1840, year 1 of Japan's Tenpo era. There lies a small village known as Kadono that is home to the siblings Jinta and Suzune. Jinta is quickly dispatched to slay demons.

In the spring of 1854, rumors spread of a demon woman who kills men in the Yoshiwara redlight district. Jinya investigates.

Jinya and Naotsugu witness a young girl losing her parents in a fire, which brings the unexpected truth of the mystery to light.