Dave Mustaine, lead guitarist and lead vocalist for Megadeth is interviewed and talks about if the Big 4 tour will ever come stateside, staying in touch and being more accessible with his fans; in the Throwdown the guest and hosts debate over who is the best German metal band: Scorpions or Accept; Jim Florentine rants about the sensitivity of some TMS viewers.

Joey Kramer, drummer from Aerosmith is interviewed and talks about what the future of Aerosmith is, his new book Hit Hard, coming to grips that Steven Tyler and Joe Perry would be the focal points of Aerosmith, if the band made better albums and songs when everybody was using drugs; in the Throwdown the guests and hosts debate who was the best theatrical rock band: Alice Cooper or KISS.

Wolf Hoffmann and Mark Tornillo from Accept are interviewed; Don and Jim open up for Twisted Sister's Christmas show that allow admittance of all ages and they try to perform clean material; in the Throwdown the guests and hosts debate what's the better album: AC/DC's Back in Black or Black Sabbath's Heaven & Hell.

Joe Lynn Turner, former frontman for Rainbow and Deep Purple is interviewed; Don and Jim babysit Eddie's children after VH1 Classic gives Eddie and his wife a night out on the town; in the Throwdown the guest and hosts debate who's the best guitarist: Ritchie Blackmore or Yngwie Malmsteen; and Eddie rants about the Rock and Roll Hall of Fame.

Scott Ian, guitarist from Anthrax is interviewed and talks about performing at Sonisphere and reuniting with former Anthrax vocalist John Bush, doing the Big 4 concert with Megadeth, Slayer and Metallica; in the Throwdown the guests and hosts debate who was the best singer for Anthrax: John Bush or Joey Belladonna; Pearl is also interviewed and talks about her debut album, touring with Velvet Revolver and Mötley Crüe, being married to Scott Ian and being the daughter of Meat Loaf.

Quiet Riot bassist Rudy Sarzo is interviewed and talks about his new book Off the Rails, his relationship with Randy Rhodes and what Ozzy Osbourne would used to do to ice machines found in hotels; in the Throwdown the guest and hosts debate who's the best frontman in hard rock: Van Halen's David Lee Roth or Aerosmith's Steven Tyler.

Comedian Brian Posehn is interviewed; Kirk Windstein from Kingdom of Sorrow gets a tattoo of the TMS logo on his chest; in the Throwdown the guest and hosts debate who's the best band out of metal's big four: Anthrax, Metallica, Megadeth or Slayer.

Kip Winger and Reb Beach from Winger are interviewed and talk about how looks influenced the band in the 1980's because of MTV, being made fun of on Beavis and Butthead, the bands friction with Metallica; in the Throwdown the guests and hosts debate who's the best metal reality star: Ozzy Osbourne or Bret Michaels; Trunk, Florentine and Jamieson do a special three minute episode of TMS at a fan's house featuring a short interview with Anthrax's Frank Bello; and Don Jamieson rants about metal fans being picky about their music.

Joe Satriani is interviewed; in the Throwdown the guest and hosts debate who's the best heavy metal guitarist: Megadeth's Dave Mustaine or Metallica's Kirk Hammett.

Outtakes and extras from season four, including Scott Ian telling the story about the first time he met Meat Loaf when he was dating his daughter; the return of Joe the Van Halen fan where Don and Jim continue to confuse him; and the complete season four results of Stump the Trunk.