When Mr. Awesome gets hold of the only thing in the world that can kill him, The Awesomes must get creative to stop him; Perfect Man discovers a secret from his past.

Unknowingly hooked up to a simulation, The Awesomes find themselves living simple lives in a small town, with Prock as the sheriff. They must relearn how to be heroes when Perfect Man and the New Awesomes think it's a violent video game.

When undersea creatures stage a series of attacks on land, the Awesomes visit an old friend, Seaman (Andy Samberg) at the bottom of the ocean; Mr. Awesome returns to Earth.

Valentines Day is ruined when Villain Tine steals all the roses in the world, Hotwire's Metal Fella suit goes rogue, and Muscleman faces the wrath of a jilted lover. The public looks to Mr. Awesome to fix the Awesomes' mess.

As election day approaches, Mr. Awesome's campaign makes a final push; when Dr. Malocchio tells the team Mr. Awesome is evil, The Awesomes are not sure who to believe.

Frantic is conflicted when he falls for a member of the Gay Mafia, a gay super villain team; Prock, Perfect Man, and Muscleman go on a road trip when Mr. Awesome appoints Prock his new campaign manager.

The Awesomes help their old friend, archaeologist Indiana Johnson, who hires them to track down his missing partner. Dr. Malocchio gets his memory back and heads back to earth to stop Mr. Awesome.

Concierge, Gadget Gal, and Hotwire join a secret all female superhero team, the Dames of Danger; the men stay home and have a guys night with Jeffrey; Hotwire faces a major life change.

Prock and his team are kicked off The Awesomes, as Mr. Awesome takes over with Perfect Man. Forced to move in with Prock's mother, they decide to start an independent superhero team, The Awesomes for Hire. Mr. Awesome announces he's running for president.

The Awesomes attend a banquet in France, and a poison in the wine makes everyone start singing. Perfect Man hunts down Impresario to arrest him for stealing a piece of his bread.