Pope Alexander fights for his life; the cardinals fight for control of the papacy; Cesare and Micheletto track the assassin; Della Rovere prepares to make his move.

Alexander tasks Cardinal Sforza with purging the College of Cardinals, old Roman families conspire against the Pope, and Lucrezia tries to seduce Cesare.

The King of Naples refuses to accept Lucrzia's child as part of the marriage agreement and pointedly invites Caterins Sforza and other Borgia enemies to the wedding.

Cardinal Farnese exposes the embezzlement of Cardinal Versucci while the King of Naples insists the consummation of Lucrezia's marriage to his cousin be witnessed.

Lucrezia and Micheletto plot the death of King Ferdinand when he refuses her her baby as Cesare's promise of an annulment for Louis X!. gain him a wife and army.

Cesare unites the sons of the five Romagna families with his own army against Forli, and the Pope negotiates for a with Constantinople Jews for a holy relic.

After the French king occupies a deserted Milan, he tasks Cesare with killing Ludivico, and Lucretia becomes involved in Neapolitan palace intrigue.

Micheleto learns his kept lover is a Sforza informant, Caterina Sforza mounts the Shroud of Turin as a rival holy relic, and Alfonso puts Lucrezia under house arrest.

Lucrezia escapes with Alfonso and her baby from Naples while the Pope corners the market in sulfur, restricting others from manufacturing gunpowder.

Micheletto returns to Cesare briefly to help him destroy the walls of Forli and capture Caterina Sforza and later recruit her assassin Rufio.