Undeterred by warnings, doctors Lúcia, Damião and Enzo travel to isolated Aguazul with a Zika vaccine. But no one is ready for the passionate pushback.

Damião makes a shocking return and brings bad news with him. The sick, injured and dying literally flood into Aguazul (Blue Water) by the boatloads. Lucia stands alone when reporting what she witnessed and she is punished alone. Enzo makes a discovery in his new laboratory job and is willing to sacrifice Lucia, again. Eva appears and claims to want to report the truth of the Chosen One and his ability to heal.

After Mateus’s shocking act, Damião follows a mysterious woman into the jungle, while Lúcia and Enzo vaccinate the villagers with unexpected results.

The Chosen One's twisted thinking makes him certain he can't heal Lucia, but Damião steps up to try and help her. Enzo's story becomes more convoluted, but not surprisingly, he still is more concerned about what he wants than who he hurts. The Serpent continues to play a larger role, Angelina grows weaker and the Chosen One becomes increasingly unstable.

Angelina's replacement is found and delivered. Eva is betrayed as she sees the truth of Aguazul. The doctors continue to bicker and the three brothers bicker and condemn Cleuza. Zulmira is downtrodden as ever. At least the jaguar seems to know who is who and some horror elements are brought into this episode.

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The Chosen One continues to change his path, seemingly on whims, but he also ties himself to Lucia again. He orders her to find Angelina's replacement with the help of Enzo so that neither Lucia nor the Chosen One die. Eva is told that she will see the truth and the Chosen One changes the schedule for the children of the village so that Eva can witness what will happen. Santiago's background is shown and we better understand why he is hostile, cruel and angry all the time.

In a bold bid for help, Lúcia challenges the cult leader to heal a nonbeliever. But the cure takes a surprising turn as the outside world presses in.

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Angelina’s story comes to light while Lúcia takes her place at the healer’s side. Damião tries to make amends -- until everything goes sideways.

Curiosity lands Damião and Enzo in Aguazul's bizarre blue water as Lúcia enters the Chosen One's inner circle and attempts to control the message.

As Lúcia looks for mercy, Damião and Enzo face the ultimate test. Compounding the chaos, outsiders descend on Aguazul, clamoring for the cure.