Brenda and the Priority Homicide Team investigate a sniper who is killing gang members in and around MacArthur Park. Offering assistance is an ex-Army colonel who believes the sniper to be his son. As an all-out gang war looms, Brenda tentatively accepts his assistance.

Brenda finds herself at odds with the FBI in a struggle to gain control of the murder investigation of a well-known businessman. Deciding to work in tandem, Brenda finds herself working directly with Fritz, who was assigned to the case.

When two Catorce gang members are shot to death, Brenda and her squad must solve the murders before a gang war erupts. Meanwhile, Brenda has her own personal health scare when she finally visits the doctor.

Brenda and the team investigate an apparent suicide that the medical examiner believes was actually a murder; Brenda's parents are staying with Fritz and Brenda for a few days.

When a gay man is murdered, seemingly the latest victim of a string of hate crimes, Brenda must confront prejudices inside and out of the LAPD. But when the perpetrator of the crimes turns out to be something quite different than expected, and has an alibi for the latest murder, Brenda must dig deeper to discover if this crime is part of the string, or a crime of passion disguised as a hate crime. Meanwhile, Flynn and Taylor step up their efforts to undermine Brenda once again, but with unexpected effects, as the team begins to rally around Brenda.

Brenda and the PHD investigate a high-profile case when a woman is brutally murdered at L.A.'s trendiest restaurant. On the home front, Brenda tries to keep a low profile as she closes in on her 40th birthday.

When a Chinese business woman is found dead on the tour bus she and her husband operate, Brenda and the squad must dig deep to investigate her past life. Meanwhile, Brenda’s parents reveal to the squad that Brenda and Fritz are engaged.

A man wearing a surveillance wire is shot to death at point blank range in downtown Los Angeles; interpersonal relationships on the squad force Brenda into a corner.

Brenda and the team are called in to investigate the questionable disappearance of a shady financial investor. The team is a mess with Daniels now in another division, Gabriel doing double duty, and Provenza with behavior more curious than usual. In the meantime, Brenda and Fritz deal with a sick Kitty.

Brenda enters the high-stakes world of pharmaceutical research, when a drug trial for new anti-addiction medication lead to the death of one of the principal investigators. Nothing is quite as it seems as she investigates the high-powered president of the drug company sponsoring the trial, the seemingly easy-going psychiatrist and the teenaged participants in the study.

When a judge is murdered in Griffith Park, Brenda's investigation takes an unexpected twist. Her best witness, or perhaps her prime suspect, is his teenaged son with autism. Challenged by the boy's behaviors, but convinced he has the clue to unraveling the case, Brenda must try to understand his disability, and thereby learn what he knows.

Things don't add up when an LA cop turns up dead. Brenda and her team race against the clock to get to the truth, while tension increases between the Priority Homicide Division and the Robbery-Homicide Division. In the meantime, Brenda's relationship with Fritz elevates to a whole new level.

Brenda and the team find themselves wading through a long list of suspects when a celebrity photographer takes a fatal fall from his hotel room balcony. Once the cause of death is determined, the motive points to a big time actor with something to hide. In the meantime, Brenda starts to feel like Fritz is behaving strangely, making her realize that superstars may not be the only ones who have secrets to keep.

Leaving the scene of an accident to get to a multiple homicide scene, Brenda finds herself unable to drive the streets of L.A. which she worked so hard to learn. Once she gets to the crime scene, she and the PHD are faced with another challenge: the murdered bodies are nowhere to be found. In order to solve this case, they must first search for the victims before they can hunt for the killer.

A car belonging to a Department of Homeland Security employee is found wrecked at the bottom of Mulholland Drive. Priority Homicide is brought in to uncover the details surrounding the driver’s death, but the investigation leads Brenda a lot closer to home then she expected.

Brenda finds an opportunity to visit home when she attempts to track down a witness who disappears to Atlanta. Unfortunately, once she finds the witness, her holidays with family take on a whole new meaning.

Brenda and the team must determine if a murder was revenge or mere coincidence when a recently released murderer turns up dead, the victim of a hit-and-run. As usual, Brenda's personal life isn't much better: she must deal with a recently incapacitated Fritz.

Brenda and the squad investigate the murder of a hair stylist; Brenda's parents stop in for a visit on their way to Alaska; Brenda's father wants to know when she and Fritz are going to tie the knot.

Fritz's sister agrees to use her psychic powers to help the Priority Homicide Division resolve one of their cases, and while her abilities appear to help her understand how Brenda works, they don't seem to stop her from offering misguided advice.

Once again working with Fritz and the FBI, the team helps get to the bottom of a murder which occurred amidst a drug ring investigation. Also again, Brenda finds FBI feathers ruffled by her unorthodox methods.

After a man is murdered while taking pictures of the stars from his balcony, the squad suspects the crime is somehow connected to the woman with whom he was having an affair. But their investigation is hindered by a missing murder weapon, as well as the difficult adjustment of moving into a new office.

While investigating a suspicious suicide, the squad wades into a nasty child-custody dispute between a dying man and his meth-addicted ex-wife. Meanwhile, Pope applies for the police chief job, but Brenda might have something to say about whether or not he gets it.

A bank robbery supposedly committed by a known gang of thieves leaves a security guard dead. It also leaves a lot of unanswered questions about the prime suspects and why this latest robbery doesn't fit their regular pattern. Meanwhile, Pope gets some news about his chances at becoming the city's police chief.

Chief of Police Tommy Delk (guest star Courtney B. Vance) assigns Major Crimes a seemingly minor case involving the armed robbery of several medical marijuana dispensaries. But when one of the robberies turns into a murder, the case becomes a test of Brenda’s readiness to move up in the department.

Brenda has to figure out how house sitting led to the death of a young lady. As the fallout from the civil lawsuit continues Captian Rader has to broaden her investigation to include the LAPD while the realignment within be in LAPD gets started.