The Drew Barrymore Show is optimism TV, bringing information, inspiration, and entertainment to the daytime audience this fall. The one hour nationally syndicated daytime show is produced and distributed by CBS Television Distribution and filmed in New York City.

Drew interviews Charlize Theron and learns the Art of Smizing with Tyra Banks! In addition, Drew reveals an obsession with “Stans for Stains,” Jimmy Fallon shares the story of the first time he met Paul McCartney, and Drew continues the #ShareTheMicNow campaign with one of its co-founders, Luvie Ajayi Jones. Plus, your favorite daily segments, Drew’s News and The Goodbye!

Drew shares today’s “Drews News”! Drew interviews Reese Witherspoon and authors Derrick Barnes & Gordon James. Phoebe Robinson reveals a secret, and Billy Eichner plays "Would Drew Barrymore Like That?"! Plus, Drew’s daily The Goodbye.

Gabrielle Union joins Drew to help surprise a small business owner, the Wig Doctor! Drew also interviews Jane Fonda and hosts a quarantine fashion show with Christian Siriano and the Crafty Lumberjacks teach Drew one of their favorite DIY projects. Plus, Drew pays her respects to the buffets we can no longer enjoy, and of course, your favorite daily segments, Drew’s News and The Goodbye!

Emma Roberts ("Holidate") talks with Drew. Big Bird ("Sesame Street") helps Drew celebrate World Kindness Day. Craft week wraps up with Danny Seo. The Weekender picks.

Drew introduces her Word of the Week, does a Friday edition of Drew’s News, retires her sweatpants and recommends her favorite new picks for weekend fun in The Weekender. Drew also welcomes Billy Porter for a flower-filled performance, and Jane Lynch shares her most starstruck moment! Plus, Drew eases the back-to-school pressure for one unsuspecting family, shows everyone how to take a Mom’s Time Out, and does The Goodbye!

Drew will reunites with ex-husband Tom Green, meets your young skateboarder Sky Brown, cooks with Tabitha Brown, and will reveals her weekend picks in The Weekender.

Drew kicks off season two at the Paramount Lot in Los Angeles, with "The Morning Show" star Jennifer Aniston. Plus, "Let's Make A Deal" host Wayne Brady stops by and put Drew and Jennifer's game skills to the test, as they play to raise funds for Wagmor Pets Dog Rescue. Then, in an all-new Drew-Gooder, Drew shines a spotlight on Dolores Sheen, a.k.a. Aunt Dolores, who has spent the last 50 years educating children from underserved communities in Los Angeles. Plus, Drew is celebrating hometown pride, all week long, with viewers sharing tours of what makes their hometown so special and unique, including today's hometown spirit tour of Boston.

Drew will interviews Andrew Rannells and SZa, Jill Kargman will stops by the Drew's News desk, and SZA has performs her song "Drew Barrymore". Plus, Eitan Bernath has shows Drew some bizarre ingredient combinations.

It's a Never Been Kissed (1999) cast reunion, with guests Molly Shannon, David Arquette and Michael Vartan reuniting with host Drew Barrymore, two decades after the beloved film premiered. Plus, join Drew and RuPaul as they embark on a new journey together and head back to school to get their high school diploma equivalent. Then, in an all-new Wildflower, Drew spotlights women who have paved their own way to success, including a NASA Aerospace Engineer working on the Perseverance Rover, which is currently searching for signs of life on Mars. Plus, Drew is celebrating hometown pride, all week long, with viewers sharing tours of what makes their town so special and unique, including today's hometown spirit tour of Denver.

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Drew will interview with Stephen Colbert and reveals a new Designed By Drew makeover.

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Drew will interview with Gwyneth Paltrow, introduces Drew La La, and a celebrates love in Love Bug.

It's Monday. Reunited and it feels so good - Adam Sandler is right here to chat about his latest movie Hubie Halloween, and it's was going to be a scary good time. Drew and Jill Kargman are also taking us on a spooky tour of a haunted pumpkin 'blaze' you'll need never to see to believe, while about Damona Hoffman will stops by for another segment of Love Bug.

Drew will interviews The Late Late Show's James Corden, drops some of the dating tips in Drew's LoveBug, and shares curated list of her top picks that for your weekend in The Weekender.

In the inaugural episode of The Drew Barrymore Show, Drew introduces her new segment “Drew’s News,” interviews co-stars Cameron Diaz and Lucy Liu, learns how to cook Chef Haile Thomas’ Islander Lively Bowl, and reveals a surprise backyard makeover for essential workers, --the Copening family-- in Designed by Drew. Plus, Drew debuts The Goodbye!

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Martha Stewart will stop by to with her own mail truck to help Drew make some special deliveries around New York City in this extra-special edition of "Dear Drew." TikTok star and upcycling expert Sarah Terensinski will shares her favorites tips on how to give a second life to everyday items. Plus, Drew and Ross Mathews are now taking their desk on the road and serving you the news sunny-side up from Washington D.C. Then, Drew is was celebrating hometown pride all week long with viewers sharing tours of what makes their town so special and unique including today's hometown spirit tour of Portland.

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Drew interviews Jane Lynch, Jay Shetty shares his anti-FOMO mindset -- the Joy of Missing Out (JOMO), and Debbie Gibson breaks down how her mundane tasks set to music went viral. And, Drew gives another mom a much-needed Mom's Time Out.

Drew will interviews Kathie Lee Gifford and Eva Chen before will whipping up some yummy Pasta al Limone with a TikTok's Pasta Queen, Nadia Caterina.