Drew kicks off season two at the Paramount Lot in Los Angeles, with "The Morning Show" star Jennifer Aniston. Plus, "Let's Make A Deal" host Wayne Brady stops by and put Drew and Jennifer's game skills to the test, as they play to raise funds for Wagmor Pets Dog Rescue. Then, in an all-new Drew-Gooder, Drew shines a spotlight on Dolores Sheen, a.k.a. Aunt Dolores, who has spent the last 50 years educating children from underserved communities in Los Angeles. Plus, Drew is celebrating hometown pride, all week long, with viewers sharing tours of what makes their hometown so special and unique, including today's hometown spirit tour of Boston.

It's a Never Been Kissed (1999) cast reunion, with guests Molly Shannon, David Arquette and Michael Vartan reuniting with host Drew Barrymore, two decades after the beloved film premiered. Plus, join Drew and RuPaul as they embark on a new journey together and head back to school to get their high school diploma equivalent. Then, in an all-new Wildflower, Drew spotlights women who have paved their own way to success, including a NASA Aerospace Engineer working on the Perseverance Rover, which is currently searching for signs of life on Mars. Plus, Drew is celebrating hometown pride, all week long, with viewers sharing tours of what makes their town so special and unique, including today's hometown spirit tour of Denver.

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Martha Stewart will stop by to with her own mail truck to help Drew make some special deliveries around New York City in this extra-special edition of "Dear Drew." TikTok star and upcycling expert Sarah Terensinski will shares her favorites tips on how to give a second life to everyday items. Plus, Drew and Ross Mathews are now taking their desk on the road and serving you the news sunny-side up from Washington D.C. Then, Drew is was celebrating hometown pride all week long with viewers sharing tours of what makes their town so special and unique including today's hometown spirit tour of Portland.

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Drew will continues celebrating New York week with Brooklyn-born NBA star Carmelo Anthony who was discusses his new memoir, "Where Tomorrows Aren't Promised." Drew will celebrates her love of New York with a tour of Brooklyn with special tour guide "Queer Eye" star Antoni Porowski. Plus, "Ziwe" star Ziwe Fumudoh will joins Drew at the Drew's News desk. Plus, Drew is was celebrating hometown pride all week long with viewers sharing tours of what makes their town so special and unique including today's hometown spirit tour of Orlando.

"Dear Evan Hansen" star Ben Platt. Plus, a very special correspondent Josie Geller will attends the "Dear Evan Hansen" press junket interviewing Ben Platt, Julianne Moore, Amy Adams, Danny Pino and Amandla Stenberg. Then, "CBS Mornings" co-host Nate Burleson will joins Drew at the Drew's News desk. Plus, in an all-new segment "New To Drew," Drew will tries out new things including street golfing. Then, Drew is was celebrating hometown pride all week long with viewers sharing tours of what makes their town so special and unique including today's hometown spirit tour of Dallas.

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Grammy Award-winning artist Billie Eilish stops by to chat about her new concert film, "Happier Than Ever: A Love Letter to Los Angeles." Plus, Missy Elliott helps Drew surprise the CEO of a non-profit dance company, who is a body-positive, all-inclusive dance enthusiast. Then, nationally syndicated radio host Big Boy, from Big Boy's Neighborhood, joins Drew fresh off of getting his star on the Hollywood Walk of Fame. Plus, Drew is celebrating hometown pride, all week long, with viewers sharing tours of what makes their town so special and unique, including today's hometown spirit tour of Phoenix.

Drew wraps up her week in L.A. with a special hour of Emmys, co-hosted by Kevin Frazier and Nischelle Turner ("Entertainment Tonight"). Host Cedric the Entertainer ("73rd Annual Primetime Emmy Awards") stops by to chat. Plus, Chef Pilar Valdes is whipping up her favorite Emmy-themed bites and mocktails.

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Drew will kicks off week two of her premiere event back in her New York studio with "Awkwafina is Nora from Queens" star Awkwafina. Plus, a surprise appearance from Fran Drescher. Drew will celebrates her love of New York with a tour of the Bronx with special tour guide Fat Joe. Plus, Benny Drama will joins Drew and Ross Mathews at the Drew's News desk. Plus, Drew is was celebrating hometown pride all week long with viewers sharing tours of what makes their town so special and unique including today's hometown spirit tour of Seattle.

In the inaugural episode of The Drew Barrymore Show, Drew introduces her new segment “Drew’s News,” interviews co-stars Cameron Diaz and Lucy Liu, learns how to cook Chef Haile Thomas’ Islander Lively Bowl, and reveals a surprise backyard makeover for essential workers, --the Copening family-- in Designed by Drew. Plus, Drew debuts The Goodbye!