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Ellen takes her audience inside Barbra Streisand’s home for a rare, unforgettable interview filled with stories and laughter. Plus, Ashlee Simpson opens up about her infamous SNL lip-sync incident, sharing what really happened and how she moved forward.

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James Denton chats about “Desperate Housewives,” guest stars, and his workout routine — plus, he takes his pants off for charity! Meanwhile, Rachel Weisz discusses her award-winning role in “The Constant Gardener” and shares behind-the-scenes stories.

Meryl Streep chats about her record-breaking Oscar nominations and shows off her accent skills, memory expert Jim Karol stuns with mind-blowing tricks, and Jason Lee stops by to discuss his hit show "My Name Is Earl!"

David Spade hilariously explains why Ellen wasn’t invited to his birthday party and gets a jaw-dropping surprise. Then, 6-year-old genius Matthew Sawchuck amazes with his astronomy knowledge, and Tommy Lee discusses college life at 42 and more!

Charlie Sheen opens up about life at 40, quitting smoking, and parenting his daughters, while Cynthia Nixon reminisces about Emmy moments, shares her love for horseback riding, and surprises Ellen with a special hosting gift.

Charlize Theron clears up the pronunciation of her name, shares her fear of public speaking, and teaches Ellen Afrikaans. Jeff Daniels talks about life in Michigan and a funny mishap with his wife. Plus, Ellen gets her eyesight checked at LensCrafters!

Jessica Alba shares the wild story of making out with a monkey, swimming with sharks, and her grandma’s grand entrances! Plus, Noah Wyle reveals how his toddler gave him a DIY haircut and just how many pets he has at home.

After winning his third Daytona 500, Jeff Gordon chats with Ellen about speeding tickets and backseat driving. Ellen also speaks with the Red Cross CEO about New Orleans relief efforts and meets women who’ve bared it all in national ads.

Ellen joins Ray Romano and Brad Garrett for a hilarious day on the golf course, then sits down with Alicia Keys for an outdoor chat you won’t want to miss!

Debra Messing joins Ellen to discuss Harry Connick Jr., life as a mom, and the chaos of live TV, all while hilariously struggling to stay professional. Hilary Duff also returns to catch up with Ellen.

Ellen surprises a superfan with a behind-the-scenes adventure on the set of “The OC” and an unforgettable cast interview. Plus, George Lopez shares the touching story of his wife saving his life and his influential achievements.

Jeff Foxworthy chats with Ellen about his record-breaking comedy albums, their stand-up club days, and his return to a simple life in Georgia. Plus, Kanye West joins to discuss his music and incredible success.

Lauren Graham chats with Ellen about moving, presenting at the Emmys, and the latest season of “Gilmore Girls.” Then, Jeffrey Tambor shares stories about his 9-month-old, his “Arrested Development” Emmy nomination, and perfecting his “losing face.”

Melanie Griffith shares stories about Antonio Banderas, tattoos, and Dakota Johnson, while Chris O'Donnell reflects on starting acting at 13 and iconic roles. Plus, Ellen’s hilarious Costco trip brings chaos and laughter to Orange County aisles!

Leah Remini chats about her baby’s funny words and receives a Lifetime Achievement Award, while Ellen and Gwyneth Paltrow hilariously go door-to-door promoting her movie “Proof.”

Felicity Huffman shares her Emmy win and a party mishap, Megan Mullally discusses her Emmy injury and win, and Blythe Danner reflects on her Emmy success, Gwyneth Paltrow, and welcoming her newest grandchild, Apple.

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Johnny Knoxville shares stories about his wildest stunts, new movie, and life with his 9-year-old daughter, while Carla Gugino discusses filming her spooky new show, extraterrestrial encounters, and living in a tepee at age 5.

Nicollette Sheridan from "Desperate Housewives" chats about the show's success, Emmy night, and teaches Ellen a cartwheel, while Chi McBride discusses his movie and late start to acting at 30.

Jodie Foster talks Halloween chaos, kids’ parties, and her first job in the Coppertone ad, with Ellen helping with costume ideas. Plus, 6-year-old dinosaur expert Joshua amazes with T-Rex facts, and Nick Cannon shares funny family stories and childhood lessons.

Alec Baldwin discusses his self-diagnosed OCD, daughter Ireland, and New Orleans relief efforts, while Alyson Hannigan reflects on her “Buffy the Vampire Slayer” fan base, her “How I Met Your Mother” role, and a memorable fan gift.

Jennifer Garner shares her pregnancy joy and efforts with Target to aid Hurricane Katrina victims, and shines in a fun game of “Madonna, Is That You?” Meanwhile, Michael Rapaport brings laughs with his dancing skills and hilarious stories.

Jerry O’Connell shares the excitement of his engagement to Rebecca Romijn, his ring-buying nerves, and love of dancing, while Fran Drescher discusses her dating life, matchmaking adventures, and meeting Gwyneth Paltrow and Chris Martin.