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A homeless man is found stabbed to death along a highway in Harris County, Texas; and a Louisville detective investigates the murder of a young man who was the prime suspect in a double-homicide case.

Detective Chris Anderson returns to his childhood neighborhood to investigate a drug-related murder.

In Miami, Det. Rolando Garcia is investigating the shooting death of a local homeless man, known for looking after his fellow transient friends. As the case begins to unravel and witnesses give up information, Garcia learns that the victim's commendable behavior may have instigated his death. And in Louisville, after a minor injury, a woman makes a routine call to 911--the call becomes anything but routine when gunshots ring out in the background. When the smoke clears, the caller finds her boyfriend shot and killed. With information from the girlfriend, lead detective Leigh Maroni must now track down the man last seen with the victim and determine whether he is a witness or the potential killer.

A man, accused of being part of a robbery attempt that ended in murder, faces trial.

A 28-year-old father is stabbed to death while at work; a 35-year-old man is shot to death in a bar bathroom.

Investigators believe a teenager who was shot to death outside a party was a victim of mistaken identity.

A 49-year-old man is stabbed 46 times and left to die; a 34-year-old man is found shot to death in a strange place.

In Louisville, a murder hits close to home when Detective Rick Arnold learns that the victim of his most recent homicide case is the brother of a good friend. If Arnold is to track down the suspect, he needs to discern between lies and truth--and real names and aliases. In Harris County, a popular teenager is gunned down on a residential street. Deputy Cory Pool and his team must determine whether the shooting was self-defense--or murder.

A young man is shot to death in the middle of the street in broad daylight; a teenager's body is found in the passenger seat of his car.

In Louisville, a sleeping family awakens to a barrage of bullets from a machine gun, leaving two young boys injured and a teenager dead. With no eyewitnesses, Detective Mickey Cohn must resort to old-fashioned detective work to solve one of the most brazen acts of violence he has ever seen.

In Harris County, Sgt. Craig Clopton and his team investigate the murder of man killed by a single gunshot while being robbed. With little evidence on the scene, they must rely on an eyewitness to help them identify their suspects. And in Birmingham, Det. John Tanks and the homicide unit work the murder of a mother of two, shot in the back outside of her car. When detectives break through the lies and deception of the sole witness, they are surprised to discover what may have triggered the shooting.

In Cincinnati, Detectives Matt Thompson and Doug Lindle are investigating the double homicide of a local hairdresser and his elderly neighbor, both stabbed to death and set on fire. When detectives discover that one of the victim's cars is missing, they begin following a twisted trail of clues they hope will lead to the killer. And in Harris County, the life of a 30-year-old mother of three comes to a violent and abrupt end when her throat is slashed by a late-night visitor. Sgt. Craig Clopton races against the clock to determine the identity of her killer and bring him to justice.

A man is convicted of murder and sentenced to life in prison after shooting a Detroit woman in her home.

In Birmingham Det. Cynthia Morrow and the homicide team try to weave together the events of drug deal gone bad when two brothers from out of town get more than they bargained for. In Louisville Det. Kristen Downs leads the investigation of a possible gang-related shooting. But when no one is willing to talk, the team is forced to turn to forensic evidence to piece together the murder.

A 24-year-old father of two is shot in the street; a 27-year-old man is found dead in a field.

A fight between two teenagers leads to the murder of a 29-year-old man and his paralyzed mother.

Updates on past cases. Included: an elderly man strangled to death in his bedroom in Cincinnati; and the case of a missing woman.

A mother is shot in her car while her three young children sit in the back seat; four cousins are gunned down while relaxing on their grandmother's porch.

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Harris County/Miami - Dep. Mario Quintanilla investigates the murder of a woman shot during a robbery of her illegal game room. Acting on a tip that his suspects are from Central America, Quintanilla races to find them before they can flee the country. And in Miami, Det. Fabio Sanchez heads to Little Haiti to investigate the homicide of two young men shot in their living room. Sanchez must track down a friend of the victims, who was with them before they were shot, to find out what he knows.

Miami/Harris County - Sgt. Altarr Williams and detective Frankie Sanchez investigate the murder of Darrell Harrell, gunned down for trying to push a group of drug dealers out of Overtown. Months pass without a lead as the team tries everything they can to keep the case from going cold. Meanwhile in Harris County, Texas, Sgt. Craig Clopton works the murder of Virgil Fuselier, found stabbed to death in his apartment. As Clopton begins the investigation he finds trail of clues that may trace back to the killer.

In Louisville, KY, a convenience store robbery left a 30-year-old employee in critical condition. And in Harris County TX, Deputies investigate the murder of a man gunned down trying to protect his neighbors who were being robbed.

Birmingham/Louisville - Det. Jerry Williams and his team investigate the murder of a young man shot dead in an abandoned apartment. And In Louisville, Det. Brenda Wescott investigates the unusual death of a woman shot dead on a residential street.