Fred and Barney become enmeshed in international spyjinks when they inadvertently become involved with a beautiful foreign agent and the villainous Dr. Sinister, who is intent on world domination.

Fred stands to inherit his Uncle J. Giggles Flintstone's estate under one condition: The family has to spend a night in his relative's eerie mansion staffed by creepy old servants.

After Fred takes a job as a department-store Santa, he proves so successful that the real Santa asks Fred to stand in for him and deliver presents on Christmas Eve.

When his neighbors' domestic fights suddenly end with the disappearance of the wife, Fred suspects Alvin Brickrock of foul play. After reading a detective magazine, he becomes convinced that Brickrock is really Albert Bonehart, wife-murderer.

Ailing Dino is taken to the vet, who diagnoses him as having a ""dinopeptic germ,"" which is common to dinosaurs but lethal in humans. But when Dino's x-rays are mistaken as Fred's, Wilma is alerted and told to prepare the only known cure: keeping the patient awake for seventy-two hours, without telling him why.

Wilma is still pregnant and Fred is trying to be calm. This shatters when the docter tells him the blessed event could happen any day now.

Fred and Barney learn that local talent is being sought for the Bedrock Bowl's premiere event, a television special starring Ann-Margrock (voiced by Ann-Margret). The boys go home and prepare for an audition, and are aided by Ann-Margrock herself (whom they fail to recognize), who comes in to the Flintstones' home to use the phone after her car breaks down.

While plumbers at the Rubble home try to unfix Fred's attempted repair job, Betty and Barney move in temporarily with the Flintstones. The wives are convinced the forced togetherness will cause problems between Fred and Barney and they are right, although the husbands go to extreme measures to try to hide their bickering.

After a squabble about finances, Wilma seeks employment of her own. She applies for an office job at the Bedrock Radio & Television Corporation, but instead becomes the hostess of the ""Happy Housewife Show,"" a situation that makes things less than happy back at the cave.

Hearing about a talent search for a new animal star to appear in ""The Adventures of Sassie,"" Fred coaches Dino and prepares for an audition. But Dino gets more than he bargained for when he lands the part.

In an attempt to cure Barney's hiccups, Fred offers his friend a swig from an experimental soft drink he has formulated. The brew turns Barney invisible, and Fred's elaborate attempts to hide the fact make Wilma wonder about her husband's sanity.

A series of strange accidents coupled with Wilma's sudden insistence on having Fred take out a life insurance policy, and her devotion to a murder mystery novel about a wife who bumps off her husband, causes Fred to wonder if his life is in danger.

With fatherhood impending, Fred promises to become more kind, considerate, and thoughtful. His willingness to change is strechted practically beyond endurance when his mother-in-law shows up to help Wilma during her pregnancy.

Movie star Rock Quarry has had enough of Hollyrock, and decides to move to Bedrock, where he is stalked by star-struck Wilma and Betty for an autograph. Meanwhile, Fred has an auto collision with the actor and invites him home to dinner, where he is recognized by Wilma despite his insistence that he is not Rock Quarry.

After telling Wilma that he is going to visit a sick friend, Fred runs off to a poker game, where he wins $200. To explain the money, he tells Wilma that he found the cash, and is dismayed when she places an ad in the newspaper to locate the owner.

Fed up with Fred's practical jokes, Barney decides to give him a taste of his own medicine. Barney sets up the gag with a stack of five, crisp $100 bills, his prize from the Sudsy-Wudsy jingle contest.

An efficiency expert hired by Mr. Slate informs Fred that he will be fired unless he gets a high school diploma. Slate offers to send Fred to school, and Wilma mistakenly assumes that Fred is being groomed for an executive position.

Trying to be neighborly, Fred and Barney offer to babysit for the Gruesome family, who've moved into Tombstone Manor next door with their weird kid and a menagerie of creepy critters.

On a visit to the Bedrock World's Fair, the Flintstones and the Rubbles take a ride in a time machine that sends them into the future with stops at ancient Rome and Arthurian England, and encounters with Christopher Columbus and Ben Franklin.

After discovering that Barney is a closet poet, Fred manages to link him up with songwriter Hoagy Carmichael and the three set out to write a hit song. The resultant tune garners the boys a moment of fame as songwriters.

Receiving a pay cut after thirteen years at the quarry, Fred decides to quit and become a bus driver. With Barney as co-pilot, Fred delivers fifty kids to school, a nerve-shattering experience. Not wanting to let the job get the better of him, he dutifully picks them up again but mis-delivers them home.

Having sold her home, Fred's antagonistic mother-in-law arrives at the Flintstone cave, and Fred tries to play cupid after meeting a rich Texan who is looking for an elderly wife. He invites the man home for dinner, but Wilma becomes suspicious of the would-be suitor.

Fred and Barney run into old friend Sherman Cobblehead, owner of The Golden Cactus Hotel in Rock Vegas, at an eatery. Cobblehead's casual promise to ""take care of"" Fred should he ever come to Vegas is misinterpreted as a guarantee that Fred will be a big winner in the casino.

Fred receives a ticket to a television game show that offers big prizes, but succumbs to stage fright before the show. Barney subs for him and wins a house boat, which Fred then tries to claim as his.

Wilma secretly empties Fred's closet of mementos for a rummage sale, including his old football uniform. But when Fred finds the goods in the Rubbles' car, where Wilma put them, he suspects Barney of being a thief.