Darien decides to have himself injected with his brother’s RNA in the hopes that he can discover how to remove the Quicksilver gland from his head.

Darien, the Keeper and Hobbes head south of the border to Santa Ruego to convince the Prime Minister to vote against installing the Biox chemical weapon system. How? By having Fawkes pretend to be a ghost and persuade the superstitious Minister to vote against the system's installation. Unfortunately, another ""spirit"" is haunting the Minister: ""La Llarona,"" a ghost who can drown men with a kiss. She confronts Darien and it is revealed she is a member of a shadowy organization that bio-engineered her with the ability to breathe water and exhale it under pressure. In the battle over the Prime Minister's vote, Darien eventually manages to drive her off and get the vote, despite the mutual attraction the two ""freaks"" share.

To bolster Agency funds, the Official comes up with a plan where he, the Keeper, and Hobbes will go to one of Arnaud's casinos and, using Darian's invisibility powers, break the bank. The first part of the plan goes well, but Darian decides to steal the remaining $7 million of the casino's money on his own. When confronted by the Official, Darian denies the theft. In response, the Official cuts off his supply of the counteragent. Arnaud contacts Darien and offers him the counteragent in return for the money. Stalemated with the Official, and with quicksilver madness coming on, Darien is tempted, but Arnaud mysteriously disappears. Darien talks with Arnaud's imprisoned brother Huiclov, who refers him to a doctor that Arnaud was visiting. darien goes to the hospital to the doctor, already red-eyed with madness. The Official has sanctioned an outsider to bring in Darien, taking an unhappy Hobbes off the case. Hobbes tracks Darien to the hospital on his own, and manages to find him with a

Darien learns that the Keeper and the Official have been keeping antidote secrets.

The agents are infected by a fatal form of Quicksilver-producing bacteria, and the Keeper must figure out how to stop it before they all die.

The Official sends Darien and Hobbes on a mission to an exclusive Agency, and they end up in “The Community”, a town made up of U.S. intelligence operatives who had their covers blown up.

The Official is forced to resign because of Darien's screw-up, and he and Hobbes have a new boss to deal with.

Kate Easton (The Value of Secrets) is on the run from Allianora. Easton is grabbed before Darien can get her to safety and put into cyrogenic suspension by Allianora's (as yet unidentified) employers. The people Allianora work for are collecting scientists for future use under their control. The Agency manages to capture Allianora, but she proves impossible to crack. So Darien secretly cuts her a deal: he'll betray the Agency and help her escape if she'll betray her bosses and help him rescue Kate. Both of them end up double-crossing each other, and Darien ends up in a cyrogenic tube when Allianora scrambles his tracking signal. He manages to escape using his invisibility and rescue Kate. However, when he returns with the Agency, the warehouse and the remaining scientists are gone.

Allianora (from ""Ghost of a Chance""), the Woman in Black, contacts Darien and invites him to join the Organization (i.e., Chrysalis). He is understandably reluctant, but she shows him top secret Agency files that show they are planning to replace him with a more cooperative Gland recipient. He investigates and finds the information to be true, but also discovers that the plan was for him to be the replacement for his predecessor. Remaining loyal to the Agency, Darien attempts to infiltrate Chryalis, and even takes up their offer to ""kill"" Allianora, suspecting the bullets are blanks. They are, but she is wary of him once he ""proves"" he is willing to kill her. Darien then tries to infiltrate Chrysalis' computer banks, but is caught. Before they can remove the gland, Allianora frees him, setting the HQ building on fire. She disappears once more.

Darien's sudden immunity to the counteragent forces the Keeper to use an untested antidote.

A patient in a coma hidden away at a secret hospital recovers and escapes, killing the guards in the process with a poisonous touch. The Agency is called in to investigate, and Darien soon learns that the patient, a ""Catevari"" (named after a Latin story of a woman fed poison until her very touch was poisonous) was another experimental subject of the Agency, like himself. The Catevari goes after the The Official, and Darien manages to save his life by quick use of the freezing properties of Quicksilver. Darian ultimately confronts Catevari, who confronts him with the fact that they both have been messed up by the Agency and should join forces. Fawkes reluctantly decides to stick with those who have helped him, and the Catevari is killed.

Arnaud seeks out Darien for help in exchange for a cure for quicksilver madness.

While suffering from memory loss and undergoing hospitalization, Bobby witnesses a strange experiment and later he and Darien investigate related disappearances.

The Keeper is accidentally injected with an experimental serum that could cause her to become permanently insane unless she can be given an antidote in time.

A disfigured woman tries to enlist Darien's help..

Darien gets called to his hometown to investigate the appearance of his dead brother Kevin.

Presumably the audience voted yes to Hobbes' decision to join Fawkes. Darien, in end-stage Quicksilver Madness, is now obsessed with finding Arnaud. Hobbes sticks close by trying to keep him from killing random bystanders. They catch up to Arnaud, but Hobbes helps him escape when it appears that the maddened Darien will kill him. Darien abandons Hobbes, who is then approached by Arnaud. Arnaud has a malfunctioning Quicksilver gland of his own, and needs to use Darien's as a baseline to get his own fixed. In return, he'll give Hobbes Stage Five Counteragent to reverse Darien's advanced condition. Hobbes helps capture Darien, and a surgeon, Dr. Reynolds, manages to adjust Arnaud's gland. Darien gets the Counteragent, but before it can take effect he tries to kill Arnaud. Arnaud escapes during the distraction when the counteragent kicks in. Later, Arnaud goes to visit Reynolds when he realizes that the surgery did not go quite right, and he is permanently invisible.

The agents find themselves hunting for the legendary Sasquatch on an Indian reservation after two men have been killed there under mysterious circumstances.

The Official sends Eberts out with the agents to capture a computer hacker who is trying to get at the Agency’s most sensitive information.

Darien rescues a 12-year-old boy from the sinister Chrysalis agency, only to discover that his body has been implanted with a deadly virus that will be released when he reaches puberty.

Darien works undercover to capture a mysterious international terrorist and finds himself facing incarceration to preserve his cover.

Darien loses his memory after being struck by lightning, and Arnaud convinces him that he is his own brother and that his Agency friends are really trying to kill him.

Darien and Hobbes are assigned to help investigate an auditor's relative's suicide, and run into a man who can see the future and use it to his advantage.

The Official is assault by an invisible man and Fawkes is suspected - Darien and Hobbes work to clear Darin and find the true assailant.

Hobbes and Darien meet with one of Hobbes' contacts to set a trap for their arch-enemy, Arnaud. Arnaud manages to escape Darien with the aid of a smoke canister, which turns out to contain a biological weapon. Darien is soon displaying flu-like illness symptoms, and is excreting black, contaminated Quicksilver. The Official and the Keeper send him to a military hospital...which Arnaud has already infiltrated. He plans to remove the Quicksilver Gland from Darien's skull via surgery, but the illness complicates matters. He must kidnap the Keeper to cure Darien so he can gain an uninfected Gland. Darien manages to escape and, overwhelmed by madness, almost kills Arnaud. The Keeper manages to stop him but Arnaud escapes. (Copyright 2002 Steve Crow)