Wendy Watson is thrust into the middle of a science experiment gone wrong while temping at a laboratory. Fortunately for Wendy, The Middleman, a crime fighting comic-book-like superhero, shows up to save the day. Impressed by how Wendy handles herself when faced with danger, and in need of a colleague, the Middleman recruits Wendy into his secret organisation.

The Middleman and Wendy investigate a haughty 14-year-old named Cindy who has a dangerous obsession with Drysea, "the world's most popular boy band".

A group of peaceful aliens with an addiction to plastic surgery are being hunted down by a homicidal entity. Meanwhile, Ben puts his and Wendy's break-up video on the internet: Wendy is not thrilled. Recap: Wendy is working on a painting of a gorilla with a gun and shows it off to Lacey. Lacey is less than thrilled but has to admit that Wendy is enthusiastic about her work. However, she also...

Wendy and The Middleman attempt to stop a revived Terracotta Warrior from unleashing a hail of fire upon Earth.

To prevent the resurrection of every vampire that has ever lived, The Middleman and Wendy search for a possessed puppet that once belonged to Vlad the Impaler. Meanwhile, Noser pulls a disappearing act.

A former Middleman, Guy Goddard, is revived from his cryogenic slumber to do battle with his arch-foe, The Candle.

Wendy and The Middleman work to contain a trout-eating zombie outbreak.

Sensei Ping is abducted by a band of Mexican wrestlers. The Middleman benches Wendy who failed to stop Ping's abduction and embarks on a solo rescue mission. However, despite The Middleman's efforts, he too is captured, which leaves Wendy to save the day.

Wendy and The Middleman don Edwardian clothing to destroy a cursed tuba from the RMS Titanic before it can harm innocent civilians. Elsewhere, The Middleman and Lacey share a movie together and consider dating.

A malign Ida who has been infested by nanobots from outer space dupes The Middleman and Wendy into initiating a lockdown at Middleman HQ.

Wendy goes undercover as a sorority sister to investigate ghost sightings at a university. Meanwhile, Tyler resurfaces and mistakes Lacey for the woman he met on the day of the Lucha Libre attack.

Wendy is abducted by The Palindrome, a supervillain, and taken to a mirror universe that is run by the ironfisted Fatboy Industries.