Jon Kelley hosts the return of The Mole, a reality-competition that follows twelve players on a worldwide adventure. One of them is the mole, a saboteur that could thwart their efforts at anytime. The games began immediately with a challenge that required each of the players to dive waterfall and grab for money -- with the exception of a single player who was left to determine which should jump for real money, and which for fake. When only a small portion of the available money is put in the pot, suspicions immediately flare as to who could be the mole. That evening, some contestants are less than satisfied with their sleeping arrangements when a set of players is told they must sleep outside. One player thwarts the rules by staying awake all night. Later, the teams are sent to a beach to participate in a scavenger-hunt style game. Though they fare somewhat better, winning a majority of the available money, evidence of possible sabotage leads some to wonder if the mole is already at work. The players nervously face the evening's first execution after airing a series of ten challenging questions regarding whom they believe to the be the mole. One player, who seemed to have been given an early advantage, is eliminated in a surprising execution.

With tension growing amongst the remaining contestants, they are asked to put what little faith they have in each other to the test in a challenge that pairs them into "Can't Trust" and "Trust Blindly" groups. Members from both of the groups pair up for a harrowing luge ride that also serves as a test of memory. A rules violation on the part of several contestants leads to a major penalty. Later, Jon Kelley sends the contestants on a spy day complete with luxurious massages. Though pleased at the opportunity to relax, the contestants are weary of an upcoming catch, and rightly so. They find that their clothes have been sent off for dry cleaning and are challenged to find suitable clothes within a short time-frame in order to join host Jon Kelley in time for a fine-dining dinner. Two contestants make a suspicious move by choosing to simply opt out of the challenge. The contestants are presented with an intriguing offer at the evening's execution.

Most likely both knowing the identity of the mole in their midst, the remaining two contestants try to thwart that mole so they may succeed in their last chances to earn money for the pot. The pressure is amped to the max in a challenge that requires the contestants to defuse a bomb in order to add $50,000 to the pot. The contestants are offered a chance to look at the mole's dossier. The nerve-wracking final quiz determines who wins the money, who is the runner-up and who is the mole.

The remaining contestants try their best to compete and gather information, but must remain ever-watchful for signs of possible sabotage from the one mole amongst them.

The contestants face a challenge involving an arduous climb. One contestant appears to require medical attention while another seems to disappear during a key moment.

The remaining players continue with the game in Mendoza, Argentina. Nicole notes her position as the "last woman standing" and states that she'd like to be the last player standing. The players visit the Lagrarde Vineyard, makers of the finest Malbec wine, where they take part in a complex challenge that involves both the solving of brain-teasers and some good, old-fashioned hoofing. Despite a strong performance in the challenge, certain activities by some players lead others to wonder if any sort of potential sabotage may have been attempted. The players later head to a bridge over the Mendoza River where they are told not only to bungee jump but also to attempt to hit a target. As an added twist, before jumping, each contestant is asked to guess how much money the group will make during the challenge. That evening, before the execution, two players hatch a conspiracy to get another contestant drunk in the hope of messing up that contestant's quiz performance.

The final episode of the season reveals the results of the quiz, determining which celebrity wins, which loses and which is the mole. Video clips give viewers a look back at what happened during the season and reveal new information on previously hidden aspects of the game. Hidden clues pointing to the identity of the mole are unmasked.

The final episode reveals the mole and the winner. Montages reveal moley action, previously-unknown alliances and more. Recaps offer a look back at some of the best moments of the first season if the show. The viewers are informed that hidden clues to the mole's identity were placed in episodes throughout the series and these clues are revealed.

The executed players return for a game called "Tequila Shooters" in which the celebrities try to deliver wine while being pelted with dodgeballs. Afterwards, a gross food challenge sends most reeling, but one is able to stomach it. Later, the celebrities take part an artistic game that leads to some of the strangest artwork ever. The quiz results in a tie, but the result is still the same: a fourth celebrity is executed and sent home.

As one contestant deals with losing his coalition partner, the contestants are all put to the test in a series of "kid games." Split into two teams, one member of each acts as the other's eyes by manipulating a camera that sends backwards images to goggles that they are wearing in a series of challenges. The final challenge of the set proves much tougher than the others, testing the mettle, speed and balance of the players in the goggles. Later on, the results of a puzzle challenge determine the sniper in a game of paintball with both money and a potential exemption on the line. Later, the penultimate quiz reveals the final three.

A sniper game provides a player with a choice between money or an exemption. A losing streak gets the players down, but a school-style challenge gives them an opportunity for big money. Some prove rather easy, while others are too much of a challenge to handle. The game becomes more complicated in a twist in which correct answers lose money for a new group answering the questions. One player claims to have psychic visions about the night's execution, but ends up being executed instead.

The players compete in a game described as a variation of "capture the flag." The game raises many suspicions as to who could be the mole and causes some finger-pointing. In Spain, the players attempt to decipher Spanish clues to search for books. Alleged verbal abuse causes one player to despair and they are executed.

The players of The Mole II: The Next Betrayal are reunited to take their guesses at who won the game and who is the mole. The answers to burning questions are revealed.

During a cold evening, the players find themselves chained together in a game of trust. Faced with the prospect of spending the night in the cold, the game forces the players to make a choice as to whether or not anyone can be trusted to make a decision that will benefit the group as the whole, rather than merely looking out for their own interests. The players later travel from Uspallata to Mendoza, described as the "Napa Valley of Argentina." Though all are excited by the change in scenery, two players in particular find themselves at each other's throats during the van ride there. The conflict is broken up only when the decision is made by some players to switch vans. At the new destination, the players are tasked with a strongly physical challenge containing a huge twist. One contestant is offered a reward if the others fail and granted a great deal of power to sabotage their chances. The results of this challenge lead to a shift in the game for many, as reputations crumble and new suspicions are formed.

The five remaining players put their money to the test while keeping their emotions in check.

Viewers meet the players and learn the concept of the game. The players begin forming coalitions in the hope of making further in the game and learning more about who is the mole. The players all take part in a sky-diving challenge. The players' banking skills are tested in an attempt to earn money for the pot.

A player is "kidnapped" and the rest use all means of transportation to try to save him in order to secure him and money for the pot. The players then split up into three Leaders, three Followers and a Good Eye player for games. One player is busted after an attempt at a sneak-peek at the show crew. Members of the Follower and Leader teams try to navigate a cornfield maze while avoiding guards attempting to hamper their progress.

The players divide into "arty" and "counting" groups and then participate in games in which they herd sheep or create a piece art designed to fool a critic. The sheep-herding group is given a choice of three dogs, with only one trained to herd sheep. They can earn $20,000 for herding them, and an additional $10,000 for counting them. What they don't know is that they've already been told the number of sheep. The players then are asked to challenging tasks, such as facing knife-throwing and fire-walking. The tasks are on a tiered-structure, with varying results worth exemptions and/or cash. The participating players are blindfolded, while another has to convince them to complete their tasks. This player is the only one who knows the truth about their tasks: that they only think they're doing something potentially dangerous.

Now that only three players are left, the remaining players take part in some final games. One mean game forces the players to answer revealing questions about each other, in the hopes of using information earned this way to find each other and earn money for the pot. In the final game, the players are locked in hotel rooms and try to decipher clues working together in order to escape and earn a large chunk of money to the pot. They fail, leading the two actual players to wonder if it was the mole's work.

A shopping spree game features the women shopping for items and the men trying to make a profit off them in a market. Later, the players play a game called Evader. This game offers some valuable money for the pot, but also exemptions to a couple of lucky players.

Mark Curry dons a cape, as promised and gives himself a superhero nickname, "Mr. Danger." The celebrities take part in aquatic games. Later, one celebrity is called out for breaking the rules. The three remaining celebrities take the final twenty question quiz to determine who wins, who loses and who is the mole.

Catch up episode for season 5 containing some new footage.

A bullfighting game confuses the players, but they are still able to earn money for the pot. Some players come face-to-face with their dirty laundry, literally, while others are asked to unpleasant tasks. One player is asked to face all four, but the stakes in this case are higher: more money and an exemption. Fortunately, the negative results are only temporary, at least in some cases.

The second group of Mole contestants come together and meet each other. They deal with a series of tasks in which they receive money in a group pot. They all receive journals where they are to record their ideas, thoughts, etc. The players must answer a series of questions to keep their belongings from being burned.

The players play a game of hide and seek and go bungee jumping for a chance to spend time with a loved one. One gets life changing news, and one is executed.