Filippos Razis, a general surgeon at the State hospital of Agios Symeon, finds a 10-year-old Roma girl abandoned outside the hospital, just as he is leaving work. He immediately gets her in the emergency room and decides to operate on her, as there are no other surgeons available.

Filippos and his wife Maritina are confronted with a harsh reality that breeds tension between them. Filippos, seeing Belou's despair, decides to operate on her brother.

Filippos tries to regain the trust of Maritina, who is growing more and more distant as the days pass. Thaleia Mela gets close to Belou Albasha.

Filippos tries to find out what has happened to Burke Albasha and confronts the hospital administrator about the child’s illegal admission into the operating room.

Filippos tries to approach Maritina, but she avoids him and decides to channel her grief into her ceramic art.

Reporters gather outside St. Symeon Hospital to cover the latest story about the kidnapping of Burke Albasha and Galateia Paraschi tries to get them out of the way to keep the scandal from affecting the hospital.

Everyone is devastated by Bellou's murder and Burke's disappearance. Erietta enlists the help of Raphael and Maritina to try and bring Filippos to his senses.

Maritina asks Filippos for a divorce. Thaleia is hugely successful after the interview with Filippos and her boss, Tasos Kalavrinos, invites her to dinner.

Maritina is perplexed to find a drug in her house, while Thaleia finds out about her father's illness and blames Raphael for keeping it from her.

Filippos is charged with willful murder. Those who know him are asked to testify in court.

Filippos quickly comes face to face with the unforgiving world of prisons. He learns about the bet on his name and pushes Maritina away from him to protect her before she has a chance tell him some important news.

Thaleia, desperate with her father's predicament, makes a decision that puts them in even greater danger. Rafail supports her, while at the same time trying to gather the evidence needed for the retrial of his friend's case.

The Police Sergeant assigns the role of a doctor to Filippos in prison, to stop the drug dealing. This infuriates Iagos, who attacks him along with his thugs, and Sergios sends Filippos straight to solitary confinement.

Rafail recovers from the accident, but realizes that his illness is getting worse. Together with Erietta and Thaleia, they speculate whether or not the car accident was a murder attempt after all.

Time has passed and Filippos has put the ward in order. Iagos gets angry and attacks Tzelos, prompting Filippos to offer him a deal: he will leave Tzelos alone in exchange for him helping him get back on his feet.

Filippos searches for Maritina and asks Rafail to help him find her. He lets him know that Maritina is having an affair with Iasonas, with whom she is raising their son.

Erietta's memories from the past come back to haunt her, causing her to experience inexplicable outbursts. Maritina and Iasonas get close and a photo of them reaches Filippos' hands. Rafail insists on finding new evidence to help Filippos, but he doesn't want to keep fighting to protect his family. Iagos has set his plan to kill Filippos in motion, knowing that he has no room for failure.

Filippos is admitted to the Intensive Care Unit of "Agios Symeon" with severe brain injury. Maritina arrives at the hospital and sees him after a long time, but their meeting does not go as she had expected. Sirhan is furious that Iagos has failed to kill Filippos in prison, so he takes matters into his own hands at the hospital.

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Filippos, a convict and fugitive, takes refuge in a farmhouse in the middle of nowhere. There he meets Sylvia Riga, a lawyer, who seems to want to help him get justice. Together they spend four years in solitary confinement until Filippos decides to go back and take his life into his own hands.

Four years later, Filippos returns to Athens, choosing an abandoned "train graveyard" as his place of refuge. The lives of Rafail, Thaleia, and Maritina have radically changed. Just as Sylvia is stressing to him that he should live in the shadows, there is a medical emergency at Agios Symeon hospital and exposes Filippos' return to his former colleagues, and not just them!

On the occasion of the opening of the new kidney transplant ward in Agios Simeon, Galateia gives a speech at the hospital, which troubles Philip. Through her show, Thaleia is led out of a casino where she and Philip and Raphael discover the reason behind the involvement of a key person in the case...

While Thaleia is watching Sylvia, Rafail realizes that someone inside the hospital is secretly giving information to Sirhan. Maritina realizes that someone is watching her house and Iasonas wonders if Filippos is back. News of a car accident makes Filippos rush to the hospital, but once there, he is faced with something other than what he expected.

Filippos finds out what kind of relationship Sylvia has with Aravantinos. And while Sirhan orders Iagos to kill Filippos, Sylvia turns to him and begs him to save him. Iagos is forced to choose between saving Filippos or himself. While Iasonas with Lena and Rafail are at Maritina's house, Filippos enters Sirhan's cafe and discovers a new clue...

Filippos and Rafail try to realize the involvement of an acquaintance in the ring and his relationship with Sirhan. Rafail learns the truth about Erietta and confronts Filippos. Rafail and Sylvia question Erietta's absence from the hospital and from Greece for so many years, while Maritina finds a mysterious card in Jason's jacket.