In the name of religious tolerance, Catherine de Medici weds her Catholic daughter, Margaret of Valois, to the young Protestant heir of the Bourbon dynasty, Henry of Navarre. Protestants and Catholics are both in attendance. This event leads to the most infamous bloodbath in France's history.

In France, Henry III still has no heir. Catherine de Medici is determined to prevent him from being the last of the Valois line and leaving the throne to Henry of Navarre. Yet again, the wind of revolt blows over the kingdom of France and leads to the assassination of Henry, Duke of Guise.

Mary, Queen of Scots is forced to abdicate and flee to England, where Queen Elizabeth has her imprisoned. Refusing to acknowledge her cousin as her legitimate heir, Elizabeth accepts to wed one of Catherine de Medici’s sons. In Flanders, William I requests military assistance from France.

The rise of Protestantism is dividing Europe. This is the beginning of the Wars of Religion. While celebrating an alliance treaty, Henry II dies during a jousting tournament. Espionage, conspiracies, treason - his son, the sickly Francis II, sees his life and his reign threatened by the Protestants

In France, perfidy and treason plunge the French Kingdom into chaos. Behind new king Charles IX, Catherine de Medici rules in the background as master of the throne. However, she is unable to prevent a civil war.

In the middle of the Renaissance, the son of Francis I shake up the foundations of Europe. Henry II, the King of France, secures a claim to the Scottish crown by marrying young queen Mary Stuart to his son, the future Francis II, heir to the French throne.