NYC is falling. Eph and Dutch frantically race to finish their new device to stop the Master before the city is overrun. Justine, Gus, and Angel fight in one last stand to stop the spreading virus. Palmer extracts vengeance for past wrongs but may have crossed the line.

Setrakian, Eph, and Nora formulate a plan to track down the Master using Jim as bait. Eichhorst and Setrakian’s pasts are revealed. At the Luss home, Neeva struggles to protect the children while encountering a mysterious stranger whose help she may not want.

After discovering the potency of ultraviolet light against the strigoi, Setrakian gains a new and unlikely disciple. A quick trip to a Brooklyn convenience store turns into a deadly all-night siege.

Humanity teeters on the edge of destruction. The Master finally reveals himself, initiating the end game of a battle in which there can be only one winner. Eph, Fet, Setrakian, and Dutch must overcome their personal differences in a last-ditch effort to vanquish the strain.

When a plane lands in New York City with everyone on board dead, Dr. Ephraim Goodweather, head of the CDC’s Canary Project, and his team are called upon to investigate. Harlem pawnbroker Abraham Setrakian races to the airport, convinced that what looks at first like a mysterious viral outbreak might be the beginning of something infinitely more sinister.

Setrakian and Fet battle for possession of the Occido Lumen, and gain a surprising new ally. A massive attack imperils Eph, Nora, and Zack's escape from New York.

The Occido Lumen is gone. Stolen. Setrakian and Fet race to recover it. Gus and Angel try to hide a secret houseguest while avoiding a police sweep, and Quinlan's thirst for vengeance is revealed.

The Master's voice proves to be more powerful and potentially fatal than Eph or Dutch anticipated. Fet and Setrakian track down the cargo from the Egyptian vessel and realize they may be in over their heads. Quinlan strikes a deal with the Ancients, but a last minute betrayal proves deadly.

Dutch fights for her life against Eichhorst as Fet, Nora, and Eph frantically search the city for her. Setrakian confronts an old acquaintance on his search for the Occido Lumen, while Gus helps the Guptas escape across the border to safety.

Fet strikes hard at the heart of the strigoi army while Justine embarks upon a risky mission to drive the strigoi out of Manhattan once and for all. Gus and Angel fight for their lives and their freedom but are faced with a moral dilemma.

With Nora gone, Eph reluctantly joins Setrakian's quest in hopes of gathering enough evidence to warrant a citywide quarantine. Fet encounters the unexpected inside the subway tunnels, and a medical emergency threatens Palmer's master plan.

After warning Kelly to leave the city with Zack ahead of the spreading plague, Eph is arrested by the FBI. Eichhorst has one final job for Gus, while Setrakian realizes that the coming eclipse is the tipping point for virus infection and the beginning of the end.

Dutch returns with a plan to broadcast Eph’s warning about the vampiric plague. However, they face a new threat when Eichhorst launches his own attack against the pawn shop. Palmer receives a special visitor, and Gus gears up for the on-coming fight but discovers there’s another mysterious factor involved.

Eph and Nora fight to save Captain Redfern's life before coming face-to-face with the horrifying effects of the virus. A spike in rat attacks signals Fet that something inexplicable is happening deep below the city. Released from jail, Setrakian begins his own merciless plan to stop the spread of the disease.

Eph and Fet recon for an all-out assault that Setrakian assures them will finally kill the Master. Gus aligns himself with a strange new force, one that may swing the fight in an unforeseen direction.

Eph concocts a plan to make and distribute a bioweapon. Gus realizes Angel can be an unlikely ally, and Kelly comes after Nora and Zack.

Setrakian and Fet use Fitzwilliam's info to attack the Master. Eph returns to NYC frustrated but energized to go after the one person responsible for killing his friends.

Eph must protect Zack against a surprise intruder into Red Hook. Gus convinces the Guptas to make a difficult choice. Fet and Setrakian set out to acquire the Lumen.

Justine takes drastic measures to counter a surprise invasion. Nora and Fet perform a useful mission while Eph and Setrakian face off against an old foe.

Eph and Dutch work together to thwart the Master's greatest ally. Justine runs into trouble with the Mayor while Setrakian tracks down the real owner of the Lumen.

New information from the Lumen forces Setrakian to seek help from his lifelong nemesis, Eldritch Palmer. Eph's new experiments to understand strigoi communication seemingly take him to the brink of madness while Fet is on a mission to discover strigoi movements across New York City.

The four survivors begin manifesting strange symptoms, but Eph and Nora's attempt to quarantine them is thwarted as the disinformation campaign begins. Meanwhile, in jail, Setrakian receives a surprise visit from an old - a very old - acquaintance.

Setrakian leads Eph, Fet and Nora in the hunt for the Master’s lair. Left behind at the pawnshop with Mariela, Zack risks his safety for Mariela's sake.

Eph and Nora work on a biological weapon to kill the strigoi, and Setrakian risks the lives of the entire group to find information about a closely guarded secret text. The Master begins the next phase of his own plan, by creating a terrifying new breed of creature and placing them under the control of Kelly.

Things have changed. The infection enters a new phase. Fet wants to celebrate, but Setrakian and Eph are worried there's more work to be done. Justine conscripts a new, unwilling army in the fight while Eichhorst angrily lashes out with a plan to strike back.