Cruz and Santiago try to track down a gang member who murders witnesses to his murders. Grace finds her mother, who doesn't seem to welcoming.

Cruz connects the dots that link Marcel Hollis to the murder of Darren Maddox, while Marcel begins to organize a street war against the 55th Precinct. Elsewhere, Yokas, Sully, and Bosco track a missing teen to a vampire cult.

Monroe and Bosco deal with an angry mother on welfare who shoots up the welfare office, Davis and Finney stake out a man and take down a prostitution ring, Faith deals with Emily, Cruz and Monroe recieve bad news about their health.

Faith investigates Bosco further, Sasha and Ty make up, Cruz goes for some spiritual healing, Carlos meets Holly's parents.

Finney and Davis are seriously injured in a car accident during a traffic jam, which was caused by a man trying to kill two people, and he succeeds. Emily's life is in danger when she falls in with the wrong crowd. Carlos buys an engagement ring for Holly.

Faith negotiates the end of a live on TV hostage situation. The leader of a vampire cult holds Emily hostage until Bosco saves the day. Cruz attempts to negotiate a deal with a gangbanger to end the war on the 55th Precinct, but instead, he organizes his troops to attack.

The series concludes with the gangbangers taking out their assault on the 55th Precinct. After some grenade explosions, the precinct is destroyed. Cruz knows that Marcel Hollis is behind the attack, and she takes his life, as well as her own. Carlos proposes to Holly, and they are married. Everyone receives their reassignments, and Sully retires. In the last few moments, Sully narrates a look into the future.

After a suspect in a jewelry store robbery starts displaying symptoms of a disease similar to SARS, the NIH is called in to figure out what is causing this, and hopefully stop this epidemic. Meanwhile, Cruz faces off with a gangbanger, who may have hired a 13 year old boy to carry out a murder. The crossover continues on Medical Investigation S01E17 Half Life (II)

Bosco and Monroe investigate a suspicious man who they find bleeding in an alleyway as they respond to an anonymous caller's claim that someone is shouting for help in the area. They become more and more skeptical when his story continues to change and they find a blood trail. When it is determined that the amount of blood would have been more than enough blood loss to kill a person, Bosco suspects that the man murdered someone and was bleeding because the victim tried to fight back.

The deaths of four teenagers in a fiery car crash profoundly affects the third watch, who were forced to stand by helplessly, unable to save the victims. They congregate at the end of the shift to dispell their sadness and anger at the horrific images of the crash. Faith, Sully and Doc spend time sitting quietly in a cafe; Ty, Bobby, Carlos and Alex go to a bar; and Kim, Bosco and Jimmy go bowling. As evening turns into day, Faith's group meets up with a young woman, Ty's group meets up with a young man, and Kim's group meets up with a young couple in love. At dawn, everyone ends up at the a beach and they build a bonfire. As the flames flicker, we see a flashback to the moments immediately preceding the car crash and discover that the young people whom they met during the course of the evening are the spirits of the teenagers who died in the crash, who were sent back down to earth to tell them that the crash could not have been prevented, and they are not to blame for being unable to

On September 10, 2001, Ty and Sully are in Atlantic City on the eve of Sully's wedding to Tatiana. Kim sinks deeper into depression. Bosco searches for anything to do after someone lets out the result of the Giants game he had taped to watch after shift. Jimmy keeps trying to catch up on some sleep after nursing a sick Joey.

After a despondent woman steps off an eight-story apartment building, the squad finds themselves in a race to transport both the woman's heart and a dying girl to a local hospital in time to save the youngster's life. The suicide hits home for Faith as she comes to grips with her own ongoing medical problems, while Doc expresses concern over the emotional effects this case will have on Kim, despite her constant reassurance that her accident was not an attempt to kill herself.

During a sweep for prostitutes, Faith and Bosco tragically misjudge a sexual encounter between a young woman and a man in a car to be consensual; the situation spirals out of control when the girl later claims she was sexually assaulted while the cops laughed it off; Carlos considers a willing Ty as a potential roommate candidate.

Feeling betrayed, Doc angrily confronts his former friend, Jerry Mankowitz, an attorney's investigator who tricked him into confiding vital information about a pending malpractice suit.

The police officers sort through the carnage and count their dead in the wake of a shootout between rival gangs. While Faith tries to interrogate Fyodor Chevchenko, a ruthless Russian mob boss, Sully worries about the severely wounded Ty and regrets causing the incident. Tatiana chastises Sully for hassling her injured son. Faith worries about Gusler, her ineffective, frightened rookie partner and a weary Doc gets some unexpected, good news about his medical malpractice suit.

During the investigation of the gang shootout, the police officers are questioned and presented with evidence that suggests that Ross was killed by friendly fire; Carlos learns that Vangie is dead and that he is the father of the baby her sister leaves at the firehouse; on the first anniversary of Bobby's death, Kim quarrels with Jimmy over her visitation with Joey and confronts a female gang during a call; and Doc is visited by the father of a former patient whose debilitating injury may have been caused by Doc's error during treatment.

When a blackout strikes the city during a heat wave, Sully prophetically warns the more optimistic Ty that trouble in the streets will swiftly ensue. After Carlos leaves the ambulance running to keep the bus cool while he and Doc are on calls, the engine catches fire and the ambulance is destroyed. A wealthy old man confined to his bed by illness offers them a large amount of money to stay with him until his daughter arrives. Doc insists that they leave to treat others more in need over the protests of Carlos. Bosco arrests a young man, Latrell Griffith, and faces a difficult decision when an immigrant shop owner shoots and wounds a teenage shoplifter. After Latrell uses his training as a medic to save the boy, a riot breaks out and Bosco, Latrell and the shoplifter barely escape. Nightfall brings more unrest as the nervous cops try to keep the peace. Faith and Fred are stuck in a elevator when the power goes out. Faith tries to calm Fred's mounting anxiety about being trapped, and is

Maritza's reckless pursuit of Buford triggers a horrific car accident that leads to multiple injuries to motorists, and triggers an explosion that severely injures Lt. Johnson and kills Alex Taylor; Doc and Kim get to the top of the promotion list; Maritza hangs Bosco and Nunez out to dry over the murder Noble committed; Doc's overwhelming guilt and grief over Alex's death leads him to a career decision; Maritza discovers that Faith has agreed to help Bosco clear Nunez by getting Noble's gun, and goes to Noble's place to intercept her, followed by Bosco and Noble; when Bosco insists on arresting Noble and Faith refuses to turn over the gun, Maritza draws on Faith, Bosco and Faith draw on Maritza, and three shots ring out.

Steeper continues his by-the-books command style and goes head-to-head with Kim when Doc doesn't report for duty on time; Sasha can't find her off-duty weapon the morning after Doc's party; Faith returns to duty at the front desk despite Fred's wanting her to remain on disability, and discovers that Bosco has lied to her about Swersky's not allowing them to be partners; a panicky Nardo kidnaps Rose and then Bosco in a futile attempt to prove that he wasn't a rat, and makes a shocking choice when he realizes that his days as a mobster have come to an end; to the horror of the squads, Doc takes extreme measures to prevent Steeper from closing the house, and forces Carlos and Kim to risk their lives to do the right thing; Sully returns a favor by reaching out and saving his friend's life in Doc's hour of greatest need.

Faith begs Fred to return home, but he refuses for a reason that infuriates his wife; Bosco turns a cold shoulder to Maritza's attempts to offer her condolences; Carlos is spectacularly unsuccessful in his attempts to hit on Grace; on the day of his son's funeral, Donald Mann exacts his revenge with the help of a dirty cop by planting bombs designed to kill the police officers he holds responsible for the death of his son; after Mann's lieutenants force a man to crash a car carrying a live bomb into the funeral home where Mikey's wake is being held, Grace takes charge and goes out of protocol to save Rose's life, and Dr. Fields later swears to have her job for it; Kim's decision not to enter the funeral home while the bomb is still live stems not from cowardice, but from maternal instincts; when Mann discovers that some of his intended targets survived the bombings, he sends machine-gun wielding minions into the hospital to finish off the job.

Ty, Sully, Bosco, and Faith rush to the scene of a school shooting; Sully and Tatiana ponder their future together; Kim continues to struggle with her depression.

Tensions still run high in the Yokas household; Lester preps Bosco for Mikey's hearing, and then pulls a switch when he cross-examines him on the stand, leading to Mikey's getting RORd; Sully realizes what a toll the job has taken on him by his reaction to the deaths of three people in a robbery at the restaurant where he eats breakfast every day; Faith and Bosco answer a call which leads them to Lester's house, where they find his daughter not breathing; Sully tracks down and arrests the restaurant murderer; after Dr. Hickman tells Faith and Bosco that Lester's wife and daughter have been severely beaten, Lester is arrested; Sully gets his LSAT results; Ty and Sasha get closer.

An explosion in a building about to be demolished leaves men trapped inside, forcing the firefighters to make terrible choices; Fred's drinking problem escalates; Doc cancels his date with Brenda.

Faith, Bosco, Carlos and a wounded Doc find themselves trapped in an abandoned tunnel and unable to reach Central on their radios; the firefighters get into mischief during a long lull between calls; when the C.O. can't raise Bosco on the radio, Sully tries to cover for him.

Bobby's attempt to keep Paulie away from drugs ends tragically.