The series concludes with the gangbangers taking out their assault on the 55th Precinct. After some grenade explosions, the precinct is destroyed. Cruz knows that Marcel Hollis is behind the attack, and she takes his life, as well as her own. Carlos proposes to Holly, and they are married. Everyone receives their reassignments, and Sully retires. In the last few moments, Sully narrates a look into the future.

After a fierce gun battle and some hand-to-hand combat, Mann's gunmen are finally subdued by the members of the 55 in the E.R., but not before Orland is murdered and Bosco is critically injured; after Kim heroically puts herself in the line of fire to save Holly and a little girl, she realizes that her days as a paramedic are over, and that her future lies in being a wife to Jimmy and a mother to their children; Grace and Dr. Fields patch up their differences and come to an understanding about her out-of-protocol field procedures; Maritza uncovers the traitor in their midst, who leads her to Mann; Faith steps over the line to avenge her partner.

The deaths of four teenagers in a fiery car crash profoundly affects the third watch, who were forced to stand by helplessly, unable to save the victims. They congregate at the end of the shift to dispell their sadness and anger at the horrific images of the crash. Faith, Sully and Doc spend time sitting quietly in a cafe; Ty, Bobby, Carlos and Alex go to a bar; and Kim, Bosco and Jimmy go bowling. As evening turns into day, Faith's group meets up with a young woman, Ty's group meets up with a young man, and Kim's group meets up with a young couple in love. At dawn, everyone ends up at the a beach and they build a bonfire. As the flames flicker, we see a flashback to the moments immediately preceding the car crash and discover that the young people whom they met during the course of the evening are the spirits of the teenagers who died in the crash, who were sent back down to earth to tell them that the crash could not have been prevented, and they are not to blame for being unable to

Chevchenko has Tatiana's son killed; Fred comes home from the hospital; and Davis gets a job offer.

Faith negotiates the end of a live on TV hostage situation. The leader of a vampire cult holds Emily hostage until Bosco saves the day. Cruz attempts to negotiate a deal with a gangbanger to end the war on the 55th Precinct, but instead, he organizes his troops to attack.

On September 10, 2001, Ty and Sully are in Atlantic City on the eve of Sully's wedding to Tatiana. Kim sinks deeper into depression. Bosco searches for anything to do after someone lets out the result of the Giants game he had taped to watch after shift. Jimmy keeps trying to catch up on some sleep after nursing a sick Joey.

After a despondent woman steps off an eight-story apartment building, the squad finds themselves in a race to transport both the woman's heart and a dying girl to a local hospital in time to save the youngster's life. The suicide hits home for Faith as she comes to grips with her own ongoing medical problems, while Doc expresses concern over the emotional effects this case will have on Kim, despite her constant reassurance that her accident was not an attempt to kill herself.

During a sweep for prostitutes, Faith and Bosco tragically misjudge a sexual encounter between a young woman and a man in a car to be consensual; the situation spirals out of control when the girl later claims she was sexually assaulted while the cops laughed it off; Carlos considers a willing Ty as a potential roommate candidate.

Feeling betrayed, Doc angrily confronts his former friend, Jerry Mankowitz, an attorney's investigator who tricked him into confiding vital information about a pending malpractice suit.

The police officers sort through the carnage and count their dead in the wake of a shootout between rival gangs. While Faith tries to interrogate Fyodor Chevchenko, a ruthless Russian mob boss, Sully worries about the severely wounded Ty and regrets causing the incident. Tatiana chastises Sully for hassling her injured son. Faith worries about Gusler, her ineffective, frightened rookie partner and a weary Doc gets some unexpected, good news about his medical malpractice suit.

During the investigation of the gang shootout, the police officers are questioned and presented with evidence that suggests that Ross was killed by friendly fire; Carlos learns that Vangie is dead and that he is the father of the baby her sister leaves at the firehouse; on the first anniversary of Bobby's death, Kim quarrels with Jimmy over her visitation with Joey and confronts a female gang during a call; and Doc is visited by the father of a former patient whose debilitating injury may have been caused by Doc's error during treatment.

When a blackout strikes the city during a heat wave, Sully prophetically warns the more optimistic Ty that trouble in the streets will swiftly ensue. After Carlos leaves the ambulance running to keep the bus cool while he and Doc are on calls, the engine catches fire and the ambulance is destroyed. A wealthy old man confined to his bed by illness offers them a large amount of money to stay with him until his daughter arrives. Doc insists that they leave to treat others more in need over the protests of Carlos. Bosco arrests a young man, Latrell Griffith, and faces a difficult decision when an immigrant shop owner shoots and wounds a teenage shoplifter. After Latrell uses his training as a medic to save the boy, a riot breaks out and Bosco, Latrell and the shoplifter barely escape. Nightfall brings more unrest as the nervous cops try to keep the peace. Faith and Fred are stuck in a elevator when the power goes out. Faith tries to calm Fred's mounting anxiety about being trapped, and is

Although Dade encourages him to keep quiet, Bosco tells Swersky everything that transpired with Maritza, Noble, the death of Willie G, and the shootout in Noble's hotel room, and confesses that he killed Noble after Noble pulled out a gun, Faith was shot by Maritza, and that he grazed Maritza's head with a bullet to keep her from killing Faith; wracked with grief that his wife has a bullet next to her spine, Fred attacks Bosco and threatens to kill him when he discovers that Faith became injured while she was helping her partner out of yet another jam; a critically injured Lt. Johnson, in excruciating pain and with only hours to live, begs Jimmy and Doc to ease his suffering; overwhelmed at the sight of Lt. Johnson's wife lashing out in heartbreak and anger, and her husband's horrific suffering and imminent death, Doc sadly helps out his boss one last time; Swersky has Maritza arrested when she refuses to tell him what happened during the shootout; Bosco learns that Noble was working f

Bosco arrests a pedophile posing as a toy store Santa, and the grateful store owner returns the favor by helping Bosco and Sasha come to the aid of a man whose house is robbed of all his children's Christmas presents; after Sully and Ty save a young homeless girl from a fire, she rekindles Sully's Christmas spirit; Carlos receives the ultimate Christmas present when his brother arrives at the firehouse bearing the gift of being a perfect bone marrow match for Kylie, as well as the news of Carlos's real name and family history; Kim and Jimmy spend a romantic Christmas Eve together; Sasha's search for the perfect gift for her nephew gives Swersky the opportunity to play Santa.

Bosco, Yokas, Sully and Davis search for a cop killer on the streets, and cope with an obnoxious new sergeant at the station house.

Ty, Sully, Bosco, and Faith rush to the scene of a school shooting; Sully and Tatiana ponder their future together; Kim continues to struggle with her depression.

In order to get enough evidence to convict C.T. Finney for the death of Ty Davis, Sr., Sully must look for the other officers involved with the incident, and also relive the events leading up to the murder.

Cruz and Santiago try to track down a gang member who murders witnesses to his murders. Grace finds her mother, who doesn't seem to welcoming.

An explosion in a building about to be demolished leaves men trapped inside, forcing the firefighters to make terrible choices; Fred's drinking problem escalates; Doc cancels his date with Brenda.

Faith, Bosco, Carlos and a wounded Doc find themselves trapped in an abandoned tunnel and unable to reach Central on their radios; the firefighters get into mischief during a long lull between calls; when the C.O. can't raise Bosco on the radio, Sully tries to cover for him.

Bobby's attempt to keep Paulie away from drugs ends tragically.

Doherty, riding on his motorcycle, is first to arrive at a multivehicle collision; Taylor is hit by a car; Tatiana goes to see Chevchenko, and tragedy ensues.

Bosco is dismayed as he watches Cruz go to the extreme lengths of planting drugs, frightening children, and faking a dying declaration in their attempt to arrest the drug dealer who killed another dealer and then tried to to kill the 12 year old boy who witnessed the crime; Nancy tells Ty that she's ending her relationship with Hancock, and gives Ty the ammunition he needs to get out from under Hancock's thumb and back to duty at the 55, as well as getting Sully's suspension from duty lifted.

Sully's stopped drinking, but his poor attitude remains; Carlos gives his two week notice; a blizzard blankets the city and the squads are called in early; an understaffed Doc defies orders and puts Carlos back on the street as the squads are kept busy rescuing victims of the storm; Faith's initial wariness about Emily's new boyfriend Eric turns out to be well-founded when he is brought into Mercy after an overdose of Special K, but doesn't remember where he left Emily after she also got high; Faith, Bosco, Sully, Ty, Doc and Carlos go out to search for Emily, and rush her to Mercy after she's found in critical condition; Faith and Fred blame each other for letting Emily go out with Eric.

Maritza's reckless pursuit of Buford triggers a horrific car accident that leads to multiple injuries to motorists, and triggers an explosion that severely injures Lt. Johnson and kills Alex Taylor; Doc and Kim get to the top of the promotion list; Maritza hangs Bosco and Nunez out to dry over the murder Noble committed; Doc's overwhelming guilt and grief over Alex's death leads him to a career decision; Maritza discovers that Faith has agreed to help Bosco clear Nunez by getting Noble's gun, and goes to Noble's place to intercept her, followed by Bosco and Noble; when Bosco insists on arresting Noble and Faith refuses to turn over the gun, Maritza draws on Faith, Bosco and Faith draw on Maritza, and three shots ring out.