In March 2000, 71-year-old Margarita Ruiz and her adult daughter Hope are senselessly murdered. Detectives and relatives are stunned and the case goes unsolved for six years. Then, fortuitously, a puzzling phone call from 1500 miles away leads investigators to the killer.

A young mother is brutally murdered in her own home, and her family is shot and left for dead.

On an evening in March of 1990, a knock comes at the door of Donna Willard's Philadelphia residence, and she finds herself face-to-face with a hooded gunman. He shoots Donna twice, killing her instantly, as her twelve-year-old son witnesses the murder from the peak of the stairs. For months, the hunt for her killer leads investigators on a maddening series of dead ends.

It's late as 26-year-old student Tracey Schoettlin finishes her serving shift at a restaurant in downtown Birmingham, Alabama. She clocks out but never makes it home. The next day, her body is found beneath a bridge with 19 stab wounds, igniting a panic throughout the city and in the media. Investigators have no credible leads and the case goes cold. Then eight months later, a man shows up and reports to police his mystical visions from God about the brutal murder.

December 23, 1981, is supposed to be a happy day for Roxann Jeeves and her son, Kristopher. It's the boy's fifth birthday and they have plans to tour a candy factory. Instead, the day ends in unthinkable tragedy. Mother and son are brutally murdered together in a field outside Dallas, Texas. Their killer flees the scene and the investigation ultimately goes cold, but the killer leaves evidence that leads Detective Larry Forsyth on an epic 20-year hunt.

An everyday teenage girl is found murdered in the Arizona desert upon Christmas Eve, 1988. Detectives soon studious her say, Cindy Monkman Apelt, who was reported missing by her husband the night prior. As investigators painstakingly fragment together an account of Cindy's sealed hours, they concern closer and closer to revealing her killer. Prosecutor Anna-Sigga Nicolazzi revisits the shocking crime behind the detectives and disclose attorney who solved the lawsuit and ultimately won justice for Cindy's associates.