The issue opens with multiple flashbacks and flashforwards to various points during the series, then it shows the confrontation between Hulk and Wolverine from the end of issue #1/issue #2. Hulk and Wolverine have a conversation where Hulk states that he was cured of his anger, (even though as Hulk becomes angrier during the course of the conversation he becomes less articulate) but a parting comment Wolverine makes about Betty Ross enrages Hulk and causes him to tear Wolverine in half. At the top of the mountain, Hulk is waiting and ready to eat one of Wolverine's legs, but before that happens a new arrival is airdropped onto the mountaintop, Ultimate She-Hulk. When asked who she is, her response is simply, "I'm plan B."

Save for the last two pages, the issue consists of advancing flashbacks from the perspective of Betty Ross, including Bruce's attempted phone call and Wolverine's meeting with Fury, jumping to three days prior when Betty unsuccessfully attempts to convince Tony Stark and Steve Rogers to save Bruce from Logan

Wolverine awakens to find his lower half missing, his body having been ripped in half by the Hulk minutes earlier. Using his keen sense of smell, he finds his legs have been thrown to the top of a mountain. As he climbs up a mountain to retrieve his legs, he recalls the events leading up to his current situation.

Wolverine goes to Casablanca with the collar that Forge created for him and confronts Betty, who had just taken a shower. He tells her to put it on but she refuses, turns into She-Hulk, and the two fight. She gouges out one of his eyes, but he stabs her in the spleen and kidney, and forces her to tell him where Bruce is. She agrees, and then turns back into Betty, and Logan leaves her.

The issue begins with Logan, in a dream state, encountering a Panda who claims that he is Logan's Spirit Animal. As the pair come to blows, the Panda says the fight between Bruce and Logan is personal. He also doesn't want Logan to tell the Hulk's last words to the people who cut off his head. Logan wakes up to find he's reduced to just a head on a tray. General Fury angrily attempts to question him on what happened. Logan initially claims he blacked out after the Hulk tore him in half, instead of admitting he was awake for Bruce and Betty's sexual encounter. He then accidentally reveals that he was awake when S.H.I.E.L.D. tried to drop a nuclear bomb on the Hulk. Fury, in an act of rage, shoots Logan in the head.

We see the events leading up to the fight between Hulk and Wolverine from Banner's point of view. The comic begins with Banner being left for dead on an off-shore ship, tied down to the deck with a bomb sitting beside him. He transforms into the Hulk at the last minute, and the explosion fails to kill him. The Hulk swims to Omaha Beach, Normandy, France, transforming back into Banner as he reaches the shore.