To find its totem, the First Elder brings Vanessa, Scarlett and Axel to an abandoned insane asylum protected by powerful vampires, where they discover the legacy of a long dead Van Helsing relative.

Vanessa relives the memories of her ancestor, Lily Van Helsing, in Colonial Hong Kong. There, she learns to control her dark side and fights the B'ah, the second vampire Elder.

Vanessa is once again resurrected and must confront her family's legacy; Axel, Scarlett and the others fend off Blak Tek's forces, who hope to add Scarlett to their list of lab rats.

On a distant island, Vanessa and Scarlett battle the Third Elder; Vanessa makes a choice about her path forward, one that Scarlett does not agree with.

Vanessa has a final showdown with the Second Elder in San Francisco. In Denver, Flesh, Doc, Julius and Jolene learn that even in a Safe-Zone, life isn't easy.

Doc and Jolene clash with Denver authorities over the repellent; Flesh chooses to face his past; Axel struggles with leaving Scarlett behind; Ivory and the Sisterhood infiltrate Denver.

In his hometown, Axel fights both his tragic past and a vicious pack of Daywalkers. Sam can't find Mohamad, and takes his anger out on Chad and Mike.

Scarlett is reunited with Axel but he is badly injured before they can find Vanessa. A mysterious man helps them find their way. Flesh and Jolene are fugitives on the run from Blaktek.

In San Francisco, Vanessa, Scarlett and Axel find and battle against the Second Elder's forces. In Denver, Flesh, Doc, Julius and Jolene rejoin American civilization as best they can.

Sam approaches his destiny. Mohamad tries to escape his servitude and imprisonment. Axel leads the San Francisco refugees to Denver. Ivory and Scab assume control of the Daywalker horde.

Sam comes to realize his dark destiny and tries to groom Mohamad to be a worthy partner. Scab and Ivory are bestowed Daywalker powers and return home to find the Sisterhood in ruins.

Vanessa, trapped in an abandoned slaughterhouse, wrestles between the light and dark sides of her own self before she can move forward on her path to find the Final Elder.

Vanessa and Sam face off to find the Last Elder, with Scarlett, Axel and Mohamad caught in the crossfire.