Sonny’s impending marriage to a syndicate boss’ daughter begins a supposedly businesslike realignment of “families,” but Vinnie learns that the wedding is a pretext for a bloody gang war.

Sonny’s cruel punishment of a lounge singer who wants out of his contract triggers a cascade of events that leads to Vinnie’s being photographed with McPike — a photo that is to be delivered to Sonny.

After Susan is arrested for Mel’s murder, Vinnie refuses McPike’s order to pull out of the Profitt case, because Susan, who has seemingly lost her grip on reality, has told him she is pregnant with his child.

Vinnie and Dan find evidence of the counterfeiting ring in Utah, but it seems to have come too easily, so Vinnie heads into the mountains to meet a billionaire recluse, Prescott Wilson, who might hold the key to the truth in the case. Frank and Vinnie convince Senator Pickering to delay passage of Senator Getzloff's trade bill while they search for the plane carrying the yen. Masters presents the Attorney General with photos of Vinnie and Kate talking with Wilson, as well as the printing plate with Vinnie's prints on it. Frank is ordered to arrest Vinnie. (source: http://www.plasticcow.com/wiseguy)

When a local priest finds a box that belonged to Pete, he takes it to Vinnie, who finds a diary of his father's inside. As he reads it, he finds out about a dark episode involving his father and the local mob. The episode uses black and white film and familiar faces to bring John's diary to life. (source: http://www.plasticcow.com/wiseguy)

In the aftermath of economist Valenti's assassination, new paths open in Vinnie's investigation of the plot to disrupt the Japanese economy. Although Vinnie strongly suspects that Masters is behind the plot, he follows the trail Masters sets out for him. Vinnie and Kate both go to Utah to track down the mysterious Mr. Wilson. (source: http://www.plasticcow.com/wiseguy)

Vinnie calls in Roger Lococco to take over the case, then holes up in a seedy hotel in Seattle. Frank is more interested in looking for Vinnie than in nailing Volchek. Paul orders Frank to continue the case and offers him another agent, which Frank refuses. Roger takes over as sheriff. Dan moves to Seattle to support Frank and look for Vinnie. (source: http://www.plasticcow.com/wiseguy)

In the aftermath of the Steelgrave case, Vinnie tries to vindicate himself of his lingering feelings of betrayal and disloyalty by risking his life to save an old friend from the Brooklyn neighborhood who has a contract out on him.

Hiding out in Vancouver after the fall of the Steelgrave empire, Aldo Baglia sees a photo of Vinnie in the paper and decides to even the score, sending Vinnie into a coma from two serious gunshot wounds. Roger, using his CIA contact, tracks down Aldo.

After rejecting an offer to finance a coup d'etat in the Caribbean, Mel Profitt becomes obsessed with a supposed voodoo death curse, and Vinnie, horrified, can only watch as Mel’s personality begins to disintegrate.

Vinnie is called to Washington to investigate a counterfeiting operation designed to sabotage the Japanese economy. Frank warns Vinnie to be careful, that there is some kind of power play going on, because Paul was mysteriously sent to Thailand, leaving Mark in charge. Vinnie suspects Masters wants to set him up for throwing the coup of Isle Pavot. Mark is relieved of duty when he loses control after his former mentor is murdered. Vinnie meets Kate Gallagher. (source: http://www.plasticcow.com/wiseguy)

Frank's reporter friend tells him about a corrupt town in Washington, spurring Frank to assign Vinnie to the case. Vinnie sets his cover as a truck driver whose rig just got repossessed. The local sheriff investigates Vinnie and finds out he used to be a cop, so he offers him a job as deputy. Vinnie prevents Bobby from killing Volchek, then fakes Bobby's death to win Volchek's trust. (source: http://www.plasticcow.com/wiseguy)

Vinnie is released from prison where he has been for two years to establish his cover. He meets his boss, Frank McPike and gets to see his coach and mentor, Jerry Greco. Greco is killed and Vinnie demands to be put in to finish the investigation. He uses his ingenuity to get a foothold in the Steelgrave crime family, but it will take a while to finish this job.

After his mother is mugged in Brooklyn, an enraged Vinnie sets out to find the punk who did it, but when he visits his mother in the hospital, it breaks his heart that she still won't forgive him for his life of “crime.”

Vinnie’s assignment to check out a contract killer leads him into a huge global contraband syndicate — an operation that far exceeds the scope of the Steelgrave family — overlorded by brother and sister Mel and Susan Profitt.

After his munitions operation starts falling apart, Mel orders Vinnie to set up a meet with the mob to use his immense cocaine trade to regain financial power.

When the bodies of two missing deputies turn up, it points to a serial killer who has been terrorizing the northwest. Volchek assigns the investigation to Vinnie when Stem loses control. Frank warns Vinnie he has to leave after Dan tells him there's a 40 man task force on the way to Lynchboro. As Volchek tries to eliminate possible suspects, Stem confesses to the murders, then electrocutes himself. Vinnie flashes back to Sonny killing himself, then snaps and takes off, stealing Frank's car.(source: http://www.plasticcow.com/wiseguy)

Vinnie nearly blows his cover when he becomes obsessed with finding out who killed his cousin, causing Frank to threaten him with dismissal. Frank desperately wants Vinnie to concentrate on nailing the Zaratzos, who are trying to arrange a drug smuggling deal with Sonny, because they killed one of Frank's agents.

After several deals go sour, Sonny starts suspecting Vinnie may be a plant. Frank orders Vinnie to drop the case when he finds out the local police have an informer in Sonny's operations. Sid has Frank picked up and tortured, but Vinnie and undercover cop Karen Malloy rescue him. Karen's disappearance points the finger at Sid as the leak.

With Mel and Susan Profitt undone, McPike begins dismantling their empire, but Vinnie demands to stay on the case to get to the bottom of Roger Lococco’s ties to a rogue CIA operation to stage a Caribbean coup d’etat.

Frank and Dan urge Vinnie to try and reconcile with Amber. At their urging, he goes to her, they make love, then she demands that they see a counselor. Following their therapist's advice, they go away for the weekend, where they both realize they're too involved in their careers to be able to maintain a relationship with each other. (source: http://www.plasticcow.com/wiseguy)

Vinnie is the fall guy in the alleged plot to disrupt the Japanese economy, prompting the Attorney General to launch a classified Senate investigation that could cost Vinnie his badge. Fearing her career is ruined, Kate attempts suicide. After hearing all the evidence, the Attorney General relieves Vinnie of his duties, stating there's enough to prosecute him for treason. Prescott Wilson arrives and places all the blame on Masters. Masters goes off the deep end and kills Strichen. Vinnie is cleared of all charges. (source: http://www.plasticcow.com/wiseguy)

Volchek becomes depressed over losing the hospital. Roger and Frank try to save Lynchboro by getting Volchek to realize he really is in control. Vinnie goes to Kousakis when he realizes the waste they're dumping is causing a hepatitis outbreak in a nearby school, then attacks Kousakis when he tells Vinnie to mind his own business. Vinnie tries to alert an official to the toxic waste, but it turns out the guy is corrupt and tells Kousakis to kill Vinnie. Feeling trapped, Vinnie kills the two gunmen sent to kill him, then flees into the night. Roger leaves, telling Frank to tell Vinnie they're now even. (source: http://www.plasticcow.com/wiseguy)

Frank has an out-of-body experience, then briefly awakens when he hears Vinnie calling him. Kousakis kills Harriet, then hides out at the church while waiting to kill Boden. Vinnie decides to try repairing the church bells in the hopes that they will awaken Frank from his coma. Vinnie discovers Kousakis in the bell tower, but Kousakis jumps to his death before Vinnie can summon the police. Vinnie repairs the bells and rings them, waking Frank.

Vinnie tells Mel Profitt he is leaving to go home to New Jersey, but Mel offers him the biggest cocaine distribution network in the country — a plum that Vinnie feels is too juicy for any undercover cop to turn down.