The Slatons are shocked by the cause of Amy's trip to the emergency room. Chris and Tammy see a new doctor, where Tammy must step on the scale again after a month of not sticking to her diet.

Tammy's new doctor gives her what feels like an insurmountable weight goal, but it's not the only challenge she's facing. Amy and Michael drop a bomb that changes everything.

Amy counts down the days until her delivery with an eccentric photo shoot, while the family worries that Jerry is derailing Tammy's diet. Tammy reveals her big secret to Jerry.

The Slaton's are larger-than-life sisters who have always relied on each other and food for support. Amy, age 31, is desperate to have children, but hasn't been able to due to her weight. While Tammy, age 32, is one step away from being bedridden.

Amy and Tammy go to Atlanta to meet Dr. Procter to discuss weight loss surgery. When they arrive, Dr. Procter gives Tammy a hefty weight loss goal before he will approve her for surgery, meanwhile the dietician has more bad news for Amy.

Amy and Tammy eagerly begin their weight loss journey. Sticking to their diets is a matter of life and death but proves to be a real struggle. The pressure to reach their goals culminates in a huge fight that threatens their diets and relationship.

After a stressful first month of dieting, the sisters head back to Atlanta for their one-month check in with Dr. Procter to find out if they are on the right path to their weight goals. The results force Amy to make a difficult decision.

Amy decides to have a real wedding ceremony because if she gets approved for surgery, she's afraid she may not survive; after the wedding, the sisters head to Atlanta hoping for a life-changing final weigh-in.

Amy undergoes gastric bypass surgery to change her life, but endangers herself by not sticking to the post-op diet. Tammy seeks support from her love interest, Jerry. Two months later, the sisters reveal the changes they've made.

While Amy reaps the benefits of weight-loss surgery, her sister Tammy worries that she gained weight during quarantine; a visit to urgent care gives Amy life-changing news; Tammy's family confronts her over her health

Tammy struggles to get back on the weight-loss wagon in order get approved for surgery, but this time, her brother, Chris, joins her on the journey. Amy must deal with one very big life-altering repercussion of having had her surgery

Tammy and Amy blame each other for their issues in therapy; when Tammy gets devastating news from Dr. Procter, her brother, Chris, makes a life-altering decision; a very pregnant Amy can't stop overeating, and the results are disastrous.

Tammy's boyfriend, Jerry, comes to visit just in time to celebrate the sisters' favourite holiday: Halloween. Tammy's sister Misty questions Jerry's intentions. Amy has to face another weigh-in after her concerning appointment with Dr. Procter.

When Tammy and Amy go see a psychic, they both get disturbing news. The family rallies together, and they are willing to try anything to help Tammy lose weight. Amy must face her worst fears when she's rushed to the ER.

Amy gets unsettling news about the birth of her baby as her high-risk pregnancy has last-minute complications; with their next weigh-in ahead of them, Chris and Tammy are cautiously optimistic until Tammy steps on the scale.

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With her weight spiraling, Tammy makes a life-altering decision.

Tammy is back from rehab, and Amy makes a decision regarding her sister.

Amy is upset that Tammy's new nurse isn't pushing her enough; Tammy has started slacking, and the family worries about what could be the cause; Chris and Tammy clash when he confronts her about the new man in her life.

Amy must confront demons from her past, and Tammy admits to cheat days.

Chris comes down on Amy for enabling Tammy.

Tammy must see a new therapist, but things don't go the way she'd hoped; Amy wants to lose her excess skin, but she gets bad news at the plastic surgeon's office; Chris faces the scale; if he's below 400 pounds, his surgery is on.

Chris faces the ultimate weigh-in to get approved for bariatric surgery. With Tammy's weight at a standstill, Amy and Michael make a life-altering decision. The family's fears about Tammy's choice in partners are realized.

While Chris makes progress after his surgery, Tammy gets discouraging news. Amy plans a unique bash for Tammy's 35th birthday. The family excitedly plans their first vacation together with all five siblings, but concerns rise about Tammy's mobility.

The family vacation starts off terribly when Tammy refuses to enter the cabin. Chris hopes he's lost enough weight to fulfill a life-long dream. A last attempt to save the vacation ends in another confrontation. The siblings discover Tammy's secret.