The family takes a trip down memory lane and revisits the important people and places who have made them who they are today, but not without jokes and hilarity along the way.

Amy and Tammy go to Atlanta to meet Dr. Procter to discuss weight loss surgery. When they arrive, Dr. Procter gives Tammy a hefty weight loss goal before he will approve her for surgery, meanwhile the dietician has more bad news for Amy.

After a stressful first month of dieting, the sisters head back to Atlanta for their one-month check in with Dr. Procter to find out if they are on the right path to their weight goals. The results force Amy to make a difficult decision.

The Slaton's are larger-than-life sisters who have always relied on each other and food for support. Amy, age 31, is desperate to have children, but hasn't been able to due to her weight. While Tammy, age 32, is one step away from being bedridden.

Amy and Tammy eagerly begin their weight loss journey. Sticking to their diets is a matter of life and death but proves to be a real struggle. The pressure to reach their goals culminates in a huge fight that threatens their diets and relationship.

Amy decides to have a real wedding ceremony because if she gets approved for surgery, she's afraid she may not survive; after the wedding, the sisters head to Atlanta hoping for a life-changing final weigh-in.

Amy undergoes gastric bypass surgery to change her life, but endangers herself by not sticking to the post-op diet. Tammy seeks support from her love interest, Jerry. Two months later, the sisters reveal the changes they've made.

Tammy's boyfriend, Jerry, comes to visit just in time to celebrate the sisters' favourite holiday: Halloween. Tammy's sister Misty questions Jerry's intentions. Amy has to face another weigh-in after her concerning appointment with Dr. Procter.

Tammy and Amy blame each other for their issues in therapy; when Tammy gets devastating news from Dr. Procter, her brother, Chris, makes a life-altering decision; a very pregnant Amy can't stop overeating, and the results are disastrous.

The Slatons are shocked by the cause of Amy's trip to the emergency room. Chris and Tammy see a new doctor, where Tammy must step on the scale again after a month of not sticking to her diet.

Amy counts down the days until her delivery with an eccentric photo shoot, while the family worries that Jerry is derailing Tammy's diet. Tammy reveals her big secret to Jerry.

While Amy reaps the benefits of weight-loss surgery, her sister Tammy worries that she gained weight during quarantine; a visit to urgent care gives Amy life-changing news; Tammy's family confronts her over her health

Tammy struggles to get back on the weight-loss wagon in order get approved for surgery, but this time, her brother, Chris, joins her on the journey. Amy must deal with one very big life-altering repercussion of having had her surgery

When Tammy and Amy go see a psychic, they both get disturbing news. The family rallies together, and they are willing to try anything to help Tammy lose weight. Amy must face her worst fears when she's rushed to the ER.

Amy is upset that Tammy's new nurse isn't pushing her enough; Tammy has started slacking, and the family worries about what could be the cause; Chris and Tammy clash when he confronts her about the new man in her life.

Amy and Michael finally move out of the duplex, while Tammy's partying phase takes a turn for the worse. Amanda tries to get through to her sister before it's too late, and Amy's in for a rude awakening at her annual check up with Dr. Procter.

Tammy hits a tipping point at rehab, and more bad news from back home sends her into a downward spiral; Chris gets a reality check during a check in with Dr. Smith; the family says goodbye to a beloved family member.

Amy feels from giving birth and finding out Michael has COVID-19; after 20 years, Chris gets back on the horse; Tammy is almost at the finish line for surgery approval, but worries she won't pass her final assessments.

Tammy's new doctor gives her what feels like an insurmountable weight goal, but it's not the only challenge she's facing. Amy and Michael drop a bomb that changes everything.

Tammy must see a new therapist, but things don't go the way she'd hoped; Amy wants to lose her excess skin, but she gets bad news at the plastic surgeon's office; Chris faces the scale; if he's below 400 pounds, his surgery is on.

Tammy struggles to cope after surviving a near-death experience; Amy realizes being an overweight mom may prove to be too much; Chris is desperate to get rid of excess skin; Amanda offloads some dead weight of her own.

Tammy is back from rehab, and Amy makes a decision regarding her sister.

While Chris makes progress after his surgery, Tammy gets discouraging news. Amy plans a unique bash for Tammy's 35th birthday. The family excitedly plans their first vacation together with all five siblings, but concerns rise about Tammy's mobility.

Amy must confront demons from her past, and Tammy admits to cheat days.

Chris faces the ultimate weigh-in to get approved for bariatric surgery. With Tammy's weight at a standstill, Amy and Michael make a life-altering decision. The family's fears about Tammy's choice in partners are realized.