Danny considers taking a new job that would ease his financial struggles after investigating the death of a wealthy man. Nicky tries to avoid involving her family when she is sexually harassed by her boss at her new internship. Garrett advises Frank to regain the public's trust after a rookie cop is caught on video questioning a pedestrian's immigration status.

When the same tragedy occurs to people who don’t appear connected, Danny must find what they have in common and who is responsible. Meanwhile, Frank helps an old friend come to terms with his alcoholism.

When a devoutly religious young woman is found murdered in a cemetery, Danny questions her family who is shocked to learn that she had a secret relationship.

A case turns personal for Danny when he works to protect a nurse from her violent ex-boyfriend. An acquaintance of Frank's comes to him with a theory regarding the death of an inmate. Jamie and Eddie help deliver a baby.

Before a Hasidic Grand Rebbe passes away, he chooses his youngest son to succeed him. But when the new appointee dies suddenly, Danny investigates the oldest son and others within the Hasidic community. Meanwhile, Henry reveals a family secret to Frank.

Danny and Jackie investigate the cut-throat world of fashion after Linda's runway model niece and a reporter are poisoned at a fashion show.

Amidst a shifting political climate, Frank goes head to head with City Council Speaker Regina over protests against police brutality. Jamie and his nephew Joe work together to locate Danny and Baez when they go missing while searching for a killer. Eddie steps up to help an abrasive woman find her father's body after it was misplaced.

When a rich woman dies of a heart attack, her eccentric daughter claims that she received a message from God, who told her that her stepfather actually murdered her. Meanwhile, the archbishop wants Frank's support for the canonization of a local priest, but a reluctant Frank takes it upon himself to investigate a rumor that the priest went too far when protesting the Vietnam War.

Danny and Baez are temporarily assigned new partners when an officer is outed and his current partner won't ride with him. Jamie and Eddie work on a revenge mission to steal a collar from a pompous detective. Frank compromises his relationship with the Archdiocese when he speaks out about equality in the police force.

Erin and Anthony try to prevent the deportation of a prominent community activist who isn't a citizen. Frank must decide if the NYPD will participate in the U.S. Marshals' high-profile raid of a local gang.

The Reagans confront hard choices on the job when Frank deals with a police captain who's losing his grip over his precinct. Danny faces backlash from Baez and Internal Affairs over a tough call he made in the field.

Frank takes matters into his own hands to save Gormley's career when complaints against him become public knowledge. Danny and Baez learn to be allies when the transgender community comes under attack.

When a girl is kidnapped, Jackie and Danny suspect her drug-addicted boyfriend is responsible; Erin's relationship with her boss takes a step forward.

When an unidentified young girl is found murdered at a debutante ball, Danny and Jackie look to the prostitute found giving her a hard time on the hotel's surveillance camera for clues. Meanwhile, Nicky gets a glimpse of her first murder victim as she rides along with Danny when he gets the call to investigate.

Baez is held hostage in an interrogation room by a distressed man who wants to see his daughter. Garrett's son gets in trouble with the law, so Garrett turns to Frank for help, creating an ethical dilemma for the police commissioner.

When a local mobster is gunned down in his car, Danny and Baez try to get information from the mob’s low-level errand boy they find tied up in the trunk before the gang retaliates. An NYPD officer asks for a new shield number to honor her late father, but Frank is conflicted because it’s the same number as his deceased son's.

An NYPD whistle-blower claims there's been abuse of power within the organization, so Frank must investigate whether this is true. Danny and Baez are suspicious of a car accident involving a pedestrian and think it may have been intentional.

When Linda's brother gets into trouble with the mob, he begs Danny to help him stay safe until it blows over. Frank faces a public relations nightmare when the lawyer of a wrongfully arrested man demands that NYPD records be made public.

Danny and Baez team up with two Russian operatives to search for a dangerous Russian man who entered the U.S. on a diplomatic visa. Frank gets involved in a sensitive case involving Archbishop Kearns.

Frank asks Erin to liaise between him and Governor Mendez regarding policy reform he privately backs, but can’t publicly support, because it goes against police rank and file. Danny and Baez become enmeshed in the world of competitive gaming when a high-profile video game streamer is murdered. Eddie and Witten suspect a live-in nanny is being abused after she approaches them on the street for help.

Frank and Garrett quarrel when Garrett refuses to walk back a quote he provided to a local newspaper. Danny and Baez discover a connection to a feud between local residents and city-sponsored hotels for the homeless while investigating a murder. Anthony is mistaken for a mafioso. Eddie pressures Jamie to take a love language quiz.

Danny and Baez investigate after a vicious attack leaves their mutual friend Maggie hospitalized. Frank and the team debate the appropriate memorial protocol for a former Police Commissioner with a questionable professional legacy.

Danny and Baez investigate a case of grand larceny tied to feuding crime families. Frank clashes with Mayor Chase when an influx of immigrants arrive in the city. Erin questions whether her district attorney campaign is compromising her day job.

Danny and Baez investigate a homicide involving voodoo with the help of Baez's old partner. Eddie and a fellow officer team up with Captain McNichols when they suspect a prestigious school is employing discriminatory admission practices.

When Erin tries to take down a gang leader using his law-abiding brother as bait, the family debates her methods.