Bull and the TAC team question whether they have a solid defense when they represent wealth manager Rachel Elliot who’s on trial for her husband’s murder, which she claims to have no memory of due to an alcohol-induced blackout. When Rachel’s reputation for aggressive behavior threatens to hurt them in court, Bull avoids jurors with “rage bias,” an inherent dislike of people who can’t control their emotions.

Bull mounts the defense of an old college friend, Eric Crawford, who is charged with negligent homicide after Eric’s youngest child kills his eldest with Eric’s handgun.

Bull and the TAC team take a difficult pro bono murder case before the holidays and realize it will take a Christmas miracle to win, as the presiding judge has a grudge against Bull. Also, Marissa pushes for an office Christmas party, and Taylor embarks on a new romance.

Bull assists in the murder trial defense of an old friend, Vivian Cahill, an in-debt professional gambler accused of killing her wealthy father to gain her inheritance. Knowing their client had a complicated relationship with her father, Bull and Benny enter into voir dire looking for jurors who sympathize with dysfunctional family relationships.

Bull takes on the trial defense of Dr. Natalie Reznick, an expert on anthrax, who is accused of orchestrating a series of anthrax attacks that terrorize the city. While the facts are against her, Bull sets out to prove the city was in such a rush to get the bacteria off the streets and calm the public's hysteria, they arrested the wrong person.

Bull assists Chunk as he represents a convict from his law school’s legal aid clinic, a woman accused of killing a guard while trying to escape during a prison transport. While the prosecution alleges the woman shot the guard as she tried to flee, Chunk argues that she is being falsely accused by a guard who attempted to sexually assault her during the transport.

Bull worries he can't convince a jury his religious leader client didn't kill his wife when a major secret the pastor is hiding about the marriage is revealed, damaging his credibility in court.

Bull and Chunk represent an emergency room doctor being sued for malpractice after she ignored direct orders to save one near-death patient in favor of helping another who was also critically injured.

Bull uses the First Amendment's freedom of speech to defend a controversial news commentator blamed for a man's suicide after she accused him on air of murder

Izzy asks Bull to petition the court to have her best friend’s body exhumed when the woman’s son alleges she was murdered, despite her death already ruled accidental.

Bull is hired to help a woman determined to go against legal advice when she insists on pleading guilty to the murder of a wealthy philanthropist who preyed on her a teenager.

Chunk does his daughter, Anna, a favor and convinces Bull to represent a teenager on trial robbery, a defendant who faces an uphill battle in court when he refuses to name his accomplice. Also, Chunk is suspicious of Anna’s older boyfriend who’s a writer with the financial resources to pay the legal fees for TAC’s teen client, and Taylor’s forced to lean on her ex-husband’s girlfriend as childcare for her son when the trial has her working around the clock.

Bull aims to win over a federal jury without the use of hard evidence when TAC represents Hank Alston, a child recovery agent charged with fraud for not having documented proof of his covert work. Also, Izzy wants Benny to consider hitting back at his opponent in the District Attorney race when the other candidate engages in mudslinging before an important debate

Bull’s team is rocked when their client, Elliott Miles, is found guilty of murder, and they must regroup as the trial enters the penalty phase in order to prevent him from being sentenced to death. But when new evidence emerges that could prove Elliott’s innocence, Bull must find a way to present it in court without being found in contempt. Also, Marissa faces hard truths about her relationship with Bull.

Bull is hired by a doctor, Samir Shadid, who’s accused by the Manhattan U.S. attorney of bribing his way into college, just as Bull’s ex-wife, Isabella, is due to give birth. As Bull waits for Izzy to go into labor, he contends with the trial’s national news, due to its connection to a high-profile college admissions conspiracy case.

Bull defends a train engineer who has no memory of a fatal crash he allegedly caused, due to a brain injury he sustained in the collision.

Business becomes personal for Bull when TAC assists with a civil suit against the bank that funded the terrorists responsible for Cable's death. Also, Marissa enlists her former homeland security co-worker and international banking cyber-investigator, Taylor Rentzel, to help with the suit.

Bull's team takes on a seemingly unwinnable case; a mute man faces the death penalty if he's found guilty of murder and arson; Bull is stunned to learn that his ex-wife is remarrying.

When Bull handles the negligent homicide defense of a building owner accused of killing tenants by carbon monoxide poisoning, the case rocks Bull and the TAC team to their core. Also, TAC’s trial defense is made more difficult when the ADA prosecuting the case is Chunk’s ex-boyfriend, Rob Jones, someone very familiar with Bull’s tricks; and Taylor is forced to reevaluate her work-life balance when she gets shocking news about her son.

Bull works to convince a jury that an alleged murder was actually a tragic accident when TAC represents a woman charged with her 3-year-old stepdaughter’s death.

Bull’s legal troubles go from professional to personal when new evidence in his bribery trial implicates his wife, Izzy. Also, the TAC team’s efforts to assist Bull in court are thwarted by his attorney, who fears they will cross a legal line to help their boss.

Bull and the team head to court one last time to finalize a negligent homicide defense that will change the nature of their company and their lives forever.

The DA hires Bull to help convict Hazel Diaz, an infamous drug dealer who murdered a police officer but has managed to avoid jail for years on an insanity defense by feigning schizophrenia.

When the team consults for the NYPD on the defense of a police officer accused of excessive force in the shooting of an unarmed man, the social politics surrounding the case create tension within their own ranks.

Bull confronts his guilt over closing his psychiatric practice to start TAC when his former patient, a young woman who is a clinical sociopath, goes on trial for killing her brother. When Bull and Benny’s client has no memory of the crime due to her mental condition, they enter a "Not Guilty by Reason of Insanity" plea and aim to seat jurors that are sympathetic to mental illness.