Neil deGrasse Tyson explains the hazards of zero-gravity intimacy. Michael Sheen talks "Masters of Sex." Jenny Mollen obsesses over Jason Biggs's ex.

Sarah Silverman opens up about a recent health scare and her fiery DNC remarks. Gloria Steinem talks politics and her Emmy-nominated Vice show.

Shannen Doherty offers a raw glimpse of how cancer has redefined her self-image, upended long relationships and changed her life -- for the better.

Chelsea Clinton speaks out about her mother's resilience, the high stakes in this election, and an "offensive" ploy by Trump. With Rose McGowan.

Chelsea sifts through the dizzying emotional and political fallout of the election with help from Sen. Barbara Boxer, Mary McCormack and Nikki Glaser.

Chelsea gives English etiquette a whirl, goes boating with Eddie Izzard, scrums with a pro rugby team and hits the pub to gauge opinions about Brexit.

Chelsea discusses Indian culture with actress Freida Pinto, haggles in a Mumbai market with Vikas Khanna, meets a guru and shakes it Bollywood-style.

Oscar winner Patricia Arquette makes an urgent plea for equal pay, and Aisha Tyler rejects the toxic female relationships depicted on TV.

"OITNB" actress Diane Guerrero reflects on her parents' deportation. Mike Colter shares the symbolism behind Luke Cage's hoodie. With Craig Ferguson.

"Bridget Jones" star Renée Zellweger looks back on a life-changing phone call. Chris Geere recalls an awkward sex scene. Plus: Who is Alex Trebek?

Amy Schumer riffs on awkward family dynamics, dating life and pressure from fans. "Shark Tank" star Mark Cuban explains his change of heart on Trump.

Chelsea taps the conservative pundit's "body double" for a biting interview. Kristen Bell finds a cure for online gloom and doom. With Jacob Soboroff.

Jason Biggs and Jenny Mollen go to work for Team Clinton. Journalist Jorge Ramos warns of a rising tide of hatred. With Isla Fisher and Thomas Lennon.

Chelsea heads to Japan to play drinking games with geishas, visit cat cafés and crying clinics, and interrogate the locals on dating, sex and more.

In the season finale, Oscar winner Jennifer Lawrence gets punchy, Chris Hardwick talks zombies, and Chelsea revisits favorite moments from the show.

Sen. Al Franken brings his humor to Congress. Sarah Silverman stands up for women's health issues. Plus, Thomas Middleditch on global warming.

Salma Hayek Pinault talks massage and marriage. CNN's Don Lemon discusses truth in journalism. Jerrod Carmichael gets real about the N-word.

NFL stars Russell Wilson and Kurt Warner, gymnast Aly Raisman and boxer Laila Ali reflect on competing, performance nerves and reinventing themselves.

Chelsea quizzes Harry Styles, chats with singer Rita Ora and talks "Game of Thrones" sexual taboos with John Bradley. With "Pod Save America" hosts.

The NFL's Reggie Bush and activist DeRay Mckesson discuss athletes' defiant response to Trump. Maggie Gyllenhaal talks "The Deuce." Plus, Macklemore.

Lea Michele chats stage fright, karaoke and turkey. CNN's Bill Weir details the plight of post-hurricane Puerto Rico. Plus, a baked spelling bee.

Former senator Barbara Boxer hails women's growing political clout. Journalist Ronan Farrow digs into the toxic consequences of sexual assault.

In the land of vodka, Chelsea braves a bracing spa ritual, tries rhythmic gymnastics with Maria Sharapova and probes the mystery of Russian men.

Jim Parsons, Rashida Jones, Gaby Hoffmann and Mary McCormack celebrate teachers who impacted their lives. With former Education Secretary John King.

Leah Remini dissects the perils of leaving Scientology, Geoffrey Rush talks Einstein and acting with monkeys, and Danny McBride riffs on movie aliens.