Chelsea kicks off a whole new journey of discovery and delinquency with guests Drew Barrymore, Chris Martin and the U.S. secretary of education.

Chelsea talks lube with Gwyneth Paltrow and lobbying with Tony Hale, tests her acting chops in a telenovela, and learns the secret to an ace TED talk.

Chris Evans and the "Civil War" cast dish on superhero culture and Hollywood's blind spots, and Chadwick Boseman schools Chelsea on Black Panther.

Chelsea talks tour life with Gwen Stefani, steps out with a colorful Harajuku squad, and studies the moon with NASA's "Mohawk Guy," Bobak Ferdowsi.

Chelsea delves into the U.S. presidential race with comedian Wanda Sykes, former Obama speechwriter Jon Favreau and a posse of senior Florida voters.

Chelsea reaches for a big note with the Grammy-winning "Voice" coach and steps into the rink with a pair of Russian figure skaters.

Senator Boxer and African-American churchgoers break down what's at stake in the 2016 election. Snapchat guru DJ Khaled preaches the keys to success.

Recovering addicts warn of porn's troubling side effects, and the "Crazy Ex-Girlfriend" star charts her journey from despair to a Golden Globe.

The actor-turned-mogul shares investing tips and joins Cindy McCain to shed light on human trafficking. Chelsea steps out as a dog walker for hire.

Avowed non-parent Chelsea grills Kate Hudson and others about the appeal of raising kids and has her nails done by a gender-nonconforming 9-year-old.

The Science Guy weighs in on Chelsea's cryotherapy experiment and his new thinking on GMOs. "Masters of Sex" star Lizzy Caplan performs a magic trick.

MSNBC's Jacob Soboroff explains the fuss over superdelegates, and astrology maven Megan Fox tries to make sense of mixed signals in Chelsea's chart.

Chelsea dives into a grueling mud race, Will Arnett puts a new spin on Trump's tweets, and "Daily Show" Hasan Minhaj talks Indian toilets.

Chelsea talks threesomes with the 'Do-Over' star, waits tables with her niece, and gets the inside scoop on Melissa Arnot's historic Everest feat.

The rapper joins California Lt. Governor Gavin Newsom to push for game-changing action on pot. Chelsea tries working out stoned with an MMA fighter.

Chelsea delves into the world of "Narcos" with star Wagner Moura and real-life DEA agent Javier Peña. Ariana Huffington warns of sleeping pill risks.

The actress opens up about her LGBT travel show and the devastating toll of the Orlando shooting. Also featuring Florence Henderson, Von Miller.

Chelsea gives Mexican teens a whack at Donald Trump, while Keith Olbermann sizes up the candidate's psyche. Anna Faris and Allison Janney talk Kegels.

"People v. O.J." star Sarah Paulson praises Marcia Clark. Nancy Pelosi calls for action on guns. Jason Biggs and Jenny Mollen share wild travel tales.

"Walking Dead" star Norman Reedus gives Chelsea a taste of motorcycle culture. Strahan talks flirting, good fortune and his new underwear line.

Comedians Adam Devine and Maria Bamford talk stand-ups, psych wards and success. Chelsea tries a mindful coloring session with Metta World Peace.

The actress details a hair-raising outing in Hawaii. Comedian Jim Gaffigan responds to the backlash over his manicure tweet. Plus, modern dating tips.

The country star reveals how girlfriend Gwen Stefani upstaged him on his birthday. Former congressman Barney Frank shares his ideal Democratic ticket.

Alexander Skarsgård reveals his punishing 'Legend of Tarzan' diet, Aubrey Plaza fantasizes about freeing dolphins, and Chelsea studies the red planet.

Chelsea sips mezcal with actor Diego Luna, gets a history lesson from Eva Longoria and grills former Mexican president Fox on bullfighting and Trump.