Neil deGrasse Tyson explains the hazards of zero-gravity intimacy. Michael Sheen talks "Masters of Sex." Jenny Mollen obsesses over Jason Biggs's ex.

Sarah Silverman opens up about a recent health scare and her fiery DNC remarks. Gloria Steinem talks politics and her Emmy-nominated Vice show.

Shannen Doherty offers a raw glimpse of how cancer has redefined her self-image, upended long relationships and changed her life -- for the better.

Chelsea Clinton speaks out about her mother's resilience, the high stakes in this election, and an "offensive" ploy by Trump. With Rose McGowan.

Chelsea sifts through the dizzying emotional and political fallout of the election with help from Sen. Barbara Boxer, Mary McCormack and Nikki Glaser.

Oscar winner Patricia Arquette makes an urgent plea for equal pay, and Aisha Tyler rejects the toxic female relationships depicted on TV.

"OITNB" actress Diane Guerrero reflects on her parents' deportation. Mike Colter shares the symbolism behind Luke Cage's hoodie. With Craig Ferguson.

"Bridget Jones" star Renée Zellweger looks back on a life-changing phone call. Chris Geere recalls an awkward sex scene. Plus: Who is Alex Trebek?

Amy Schumer riffs on awkward family dynamics, dating life and pressure from fans. "Shark Tank" star Mark Cuban explains his change of heart on Trump.

Chelsea taps the conservative pundit's "body double" for a biting interview. Kristen Bell finds a cure for online gloom and doom. With Jacob Soboroff.

Jason Biggs and Jenny Mollen go to work for Team Clinton. Journalist Jorge Ramos warns of a rising tide of hatred. With Isla Fisher and Thomas Lennon.

Chelsea heads to Japan to play drinking games with geishas, visit cat cafés and crying clinics, and interrogate the locals on dating, sex and more.

In the season finale, Oscar winner Jennifer Lawrence gets punchy, Chris Hardwick talks zombies, and Chelsea revisits favorite moments from the show.

In the land of vodka, Chelsea braves a bracing spa ritual, tries rhythmic gymnastics with Maria Sharapova and probes the mystery of Russian men.

Avowed non-parent Chelsea grills Kate Hudson and others about the appeal of raising kids and has her nails done by a gender-nonconforming 9-year-old.

Chelsea invites a politically diverse group including W. Kamau Bell and S.E. Cupp to dissect the rise of Trump and the issues that divide Americans.

Chelsea sips mezcal with actor Diego Luna, gets a history lesson from Eva Longoria and grills former Mexican president Fox on bullfighting and Trump.

Comedian David Cross mourns the "quaint" early stages of Trump's campaign. Chelsea and "Sully" actor Aaron Eckhart talk phobias and hypnosis.

Sparks fly as Chelsea talks cats, fame and Obama with comedian Marc Maron and actress Natasha Lyonne. Plus, Olympic swimming champ Nathan Adrian.

Chelsea dives into a grueling mud race, Will Arnett puts a new spin on Trump's tweets, and "Daily Show" Hasan Minhaj talks Indian toilets.

Chris Pratt and his "Magnificent Seven" posse talk feisty horses and behind-the-scenes bromance. Chelsea heads to the racetrack for jockey school.

Lea Michele's tales of stripping down take even Chelsea by surprise. NBA Hall of Famer Reggie Miller salutes Colin Kaepernick. With comic T.J. Miller.

"Girl on the Train" actor Edgar Ramírez rips harmful gender stereotypes. Jessica Alba shares the key to her Honest Company success. With Gavin Newsom.

Stella and Mary McCartney talk fashion, royalty and sisterhood. Craig Ferguson offers a primer on Scotland. Plus, Colleen Ballinger and Kimbal Musk.

Jake Tapper weighs in on Donald Trump's shifting positions, Maria Shriver critiques Chelsea's interviewing style, and Matt LeBlanc talks "Top Gear."