Josh Mankiewicz reports on the mysterious disappearance of a Colorado rancher.

The survivor of a horrible attack is convinced police have the wrong suspect.

Dennis Murphy has the latest on the case of a Florida law professor murdered in his garage, including new details, newly-released evidence and bombshell testimony from a long-awaited trial.

After filming wraps on an indie horror movie, the cast members learn that their lead actress is not who she says she is and has been charged with killing her uncle.

When a doctor is found murdered, investigators are stumped as to who would want him dead. Police discover simmering jealousies and a love triangle. Andrea Canning has the latest developments.

A mother of two goes missing in Monrovia, California. As detectives investigate, the woman's friends and family reveal that she feared she was being stalked. Josh Mankiewicz reports.

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An Arkansas realtor goes missing after showing a house. When loved ones later receive mysterious text messages from her, they know something isn’t right. Andrea Canning reports.

When college student Helene Pruszynski is found murdered, her case remains cold for nearly 40 years until a new detective uses an innovative method to catch the killer. Josh Mankiewicz reports.

In Morris, Alabama, faith is a way of life. But when a man is murdered, rumors involving a pastor begin to swirl and the truth ends up turning the community upside down. Andrea Canning reports.

When a woman dies after what appears to be an accidental fall in the shower, two friends join forces to seek justice on her behalf. Andrea Canning reports.

After Ellie Green doesn't hear from her mother for a few days following an argument, she begins to worry. Then she learns her mother is dead. But is that the truth? Keith Morrison reports.

When Ohio resident Pat Sabo is offered $50,000 to kill someone hundreds of miles away, he calls the police to report the incident; acting quickly, investigators set up an elaborate sting operation to bring down those behind the murder-for-hire plot;

When a pediatric dentist is found dead, police uncovers a complex plot and their suspect leads investigators on an international manhunt; the lead detective speaks out for the first time;

When a soldier, Vannessa, vanishes from Fort Hood, her family do everything they can to bring attention to her disappearance; Secretary of the Army Ryan McCarthy speaks about the investigation and allegations of sexual assault in the military;

After Todd Chance is murdered, police follow a trial video evidence as they work to track down the killer;

Top executives at Pfizer, Moderna, and Johnson and Johnson talk about plans for COVID-19 vaccine distribution and efforts to overcome public mistrust; interviews with key advisors from President Donald Trump and President-Elect Joe Biden's COVID-19 task forces;

A 40-year-old Minnesota woman is shot to death in her bed, while her husband and teenage daughter are home, leaving investigators to wonder who would want her dead;

The latest in the case of a missing young Oregon woman, whose disappearance led to an intense manhunt, after a suspect embarked on a two-state crime spree;

More than 2 decades since the tragic death of Princess Diana, Dateline reveals new insights into the real story of the very private royal, including a look at Diana's troubled marriage, her turbulent life in the royal family, and the investigation into her death;

The families of George Floyd, Jacob Blake Jr, and Eric Garner open up together in a raw and emotional conversation about their pain, anger, and frustration over police violence;

A romantic Mediterranean cruise, which was intended to rekindle the love between a woman and her ex-husband, had led to the vanishing of her; the investigation would reveal secret recordings, a surprising star witness, and an undercover hit man;

The deadly shooting at U.S. District Court Judge Esther Salas’ home that left her husband Mark injured and their son Daniel dead.

Keith Morrison has the latest developments in the case of a 21-year-old UCLA student, whose body was found in an infamous Los Angeles area train tunnel in 1990.

When University of Utah athlete Lauren McCluskey is found murdered on campus, investigators learn that she had reached out to the campus police for help multiple times before her death. Josh Mankiewicz reports on the latest significant changes and consequences the school is facing.