As the seniors prepare to graduate, Holly J. prepares for her kidney transplant, Fiona deals with some difficulties, and Katie considers taking things to the next level with Drew.

The Degrassi students attend prom. Drew invites his ex-girlfriend, Bianca to the prom, and things are awkward with his current girlfriend Katie. Riley and Zane talk for the first time since their breakup, Riley tells Zane his mother accepts him. Clare talks to Jake about how their parents marring will affect their relationship, and he breaks up with her. Vince, the gang member comes to fight Drew, when that fails, a gun is pulled, and Adam, Drew's transgender step-brother, is shot in the shoulder. Miss Oh and Sav both find out via text message, as they have snuck away to Degrassi. Bianca decides to shoot Vince, but Drew talks her out of it. They call the police and Vince and his gang are arrested, The next day the heat between Miss Oh and Sav is still there.

Holly J. finds her birth mother, and after mustering the strength to ask her to be a kidney donor, she asks Holly J. for $20,000. Adam worries that Katie is not attracted to him, because of his growing breasts, he asks to have surgery, but is too young, and instead wears a compression vest. Imogen has feelings for, and continues to flirt with, Eli, but she receives nothing in return.

Holly J. starts to look for a kidney donor within her family, and when she finds out no one has the same blood type, she starts to suspect she was adopted, which are proven true. Adam is attracted to Katie, and thinks she may be reciprocating this feeling, but when Marisol says otherwise, he worries about his female appearance. Imogen wants to play the role of Clare in the school play, so she begins shadowing her.

With Katie gone, Fiona and Imogen scheme to end Marisol's reign as president by throwing an end-of-semester holiday carnival. Meanwhile, Fiona finds out her mother is in legal trouble and that their assets have been frozen. Also, Clare agrees to put together a school newspaper in a week, meaning she has to reconcile with old friends. And Maya, an expert cellist, has trouble fitting in with the Grade 9 band.

Dave and Adam vie for a position on the school's radio system, and Sav ends up giving them a two man show. When Adam is in the washroom trying to observe Dave's urinal stance, Dave mistakes it for a peak at his penis, then later when Adam tries to use a stand up to urinate device, Dave is curious, and Adam drops the device. Dave takes his frustrations to the radio show the next day, posing the questions if trannys should enter the boy's washroom, offending Adam. Fiona joins the grade 11 drama class, but instead skips school to spend time with Charlie. Clare writes a newspaper piece hoping to join the newspaper, but is overzealous, and does not get in because she wrote more than Katie had asked for.

Jenna struggles to find a way to attend Degrassi again, so K.C.'s mother agrees to watch the baby, Tyson, in the mornings. Jenna leaves Tyson unattended, and he falls off a table. Sav, with a crush on Miss Oh, competes to write the score for the school play. He wins, but is blackmailed into working with his competitor. When Clare finds out Eli has hired Jake to construct sets, she worries Eli is out to harm Jake.

Jenna and K.C. get a visit from child services, after Jenna finds out K.C. has been cheating with Marisol at work. Their arguments grow as K.C. continues to leave Tyson with Jenna, and they decide to break-up, and put Tyson up for adoption. Sav's love song to Miss Oh is leaked to her, and thinking things have been ruined between the two, Sav attends a concert, where he meets Miss Oh on a friendly basis. Clare is concerned Eli is jealous of Jake, but after reading the school play, she finds out Eli has made her character the hero.

Drew sees Bianca with the gang member that orchestrated his beating, and finds out that she has been dating him to keep Drew safe. Drew decides to meet him, and says the debt is done, although not reciprocated. Clare and Jake keep their relationship secret from their parents, until the parents announce their engagement. Now that school is done, Sav hopes to have a night alone with Miss Oh, but is unable to.

Clare cannot figure out why Eli has no feelings after their breakup. She then meets Jake, a transfer to Degrassi, and the son of her mother's friend. He helps her realize that it is her who still has feelings, and needs to deal with her relationship with Eli. The next day, Eli tells her he is taking anti-anxiety drugs. Jenna is overwhelmed with the baby, and gets mad that K.C. is not helping. After dumping the baby on him, they decide Jenna and Tyson should move in with K.C. and his mother.

Despite Imogen's efforts, Eli is obsessed with getting Clare back, to the point of framing Jake for drug possession. His feelings erupt at the end of the school play, in an improvised monologue, saying there are no happy endings in life. Anya's army application is rejected when she fails the drug test, and her secret is revealed to her mother, but she continues to pursue this career path. K.C. and Jenna give up their baby, Tyson for adoption.

After Holly J. and Anya gets dates to prom, Fiona hopes to ask Charlie, her ex-girlfriend to the prom. She finds out that Charlie has a girlfriend, and she only wants to be friends with Fiona, this leads to a relapse into drinking. Anya is accepted into the army, and begins physical training with her ex-boyfriend Owen, leading to his interest in her again. Katie's assumes that the prom night with Drew will lead to sex, and begins preparations.

The Degrassi students return from a summer of activities a week before the new school year. Jake and Clare are still not talking, and their parents wedding sends Jake looking for space away from Clare. Katie is concerned that Bianca has been spending too much time with Drew, and Alli returns to Dave to find out he has cheated on her. Jake invites Katie, Drew, Marisol, and Alli to his remote cabin for a summer ending event, when Clare finds out, Bianca agrees to drive her. Clare arrives to find Alli kissing Jake, and runs into the woods, Jake and Drew follow, but Eli finds her first. Marisol freaks out when strange things start to happen, and Bianca keeps making references to horror movies. Marisol and Katie decide to relax with some weed Marisol found in the couch, but the two become paranoid in a shed. When repairing Clare's wound, Jake admits he still has feelings to her, the night ends with Clare and Jake's parents checking in on the party. The following morning Clare and Alli separate as friends, Katie becomes more comfortable with Bianca around, and Clare's and Jake's flirtation returns.

The grade 12 class decides to let Imogen take the blame for the overnight cafeteria prank. When Fiona feels bad for Imogen, she decides to come clean, but Katie and Marisol stick to their story, and Fiona's and Imogen's friendship returns. When Clare tells Jake she is ready for sex, Jake begins to worry about the commitment he is making. Maya asks Zig to let Tori have closure from their past relationship, but it backfires, and Zig begins dating Tori again.

It is spring break for the students of Degrassi. Drew breaks curfew to attend a Keke Palmer concert with his girlfriend, Bianca. There she meets an ex-boyfriend, who is involved in a gang, and he takes her to an alley. Drew catches him trying to rape Bianca, and in the ensuing altercation, Bianca knocks him out, and loses her bracelet. Sav meets Palmer on the street, not knowing it is her, and she invites him to the concert, and then on stage with her. Fiona's vacation plans are scrubbed, and she instead attends an art class with Holly J., where she asks out the model.

Drew and Bianca find out that the gang member was killed, and she convinces him to keep quiet. When looking for Bianca's lost bracelet, she and Drew are told by another gang member, Vince, that they are going to be killed. In order to be kept safe, Drew finds out he must shoot someone to enter the gang. He then considers the situation, and turns himself into police. Sav, now with a crush on Keke Palmer, meets up with her, and she decides to elude her entourage with him. In a later video chat, Keke tells him she does have feelings for him. Fiona takes her date to her loft, where things move too quickly for Fiona, but they decide to first be friends, and then move on from there.

Fiona is nervous about making new friends in her new class, and decides to hold a party. After the apprehension of Imogen attending, a truth or dare game leads to a prank at Degrassi. Clare's and Jake's secret relationship grows, and Clare begins to consider having sex. Maya shows a liking to Zig, but past classmates Tori and Tristan warn her about Zig.

Jacinta ignores Dave's rejection at the model UN, straining his renewed relationship with Alli. While trying to escort Jacinta to the train station, she runs off with his phone, and is hit by a car. Adam meets his blind date, Tristan, and after some encouragement from Clare, Adam give Tristan a pep talk for coming out. Marisol realizes she has feelings for Mo, and the two share a kiss.

Drew considers his relationship with Katie. Dave finds himself in a situation.

Fiona is upset over having to leave Degrassi on top of dealing with funding for the expensive carnival and her growing feelings for Imogen. Meanwhile, with the clock ticking on the deadline for the newspaper, Clare has to confront her feelings for Eli head on when he wants to get back together with her. Also, desperately searching for a challenge, Maya considers auditioning for a band at a bar.

Not being accepted into her first university choice, Anya feels pressure from A student Holly J. and partying boyfriend Owen to make the right choices. To try to get away from it all, Anya decides to do cocaine. Fiona discovers bed bugs in her loft, and assumes it is her new roommate Charlie's, and in turn they learn about each other. Connor claims his girl underwear fetish is over, and plans to make a phone app for girl's clothing, but gets caught in the women's washroom.

Anya attends an interview to get her accepted into another university, but when it does not go well, she takes cocaine, and becomes erratic. When Anya does not get the university acceptance, she continues to take the drug, and defies her mother. Fiona struggles in telling Charlie her previous problems with alcohol, and learns she is still unable to be around it. Alli recognizes her clothes in Connor's app, and tells Principal Simpson, Connor was in the girl's washroom. Simpson suspends him, and he attends an academic behaviour program, to help him deal with his Asperger syndrome.

Eli's unstable, off medication self, convinces he can start up a relationship with Clare, but everyone else, save Imogen, just find him crazy with the multiple script changes. K.C. and Jenna interview a couple to adopt the baby, but K.C. has second feelings when the prospective parents says they are not into sports. Anya continues her cocaine addiction, as she tries to find a career path, she sees an advertisement for the Canadian Forces.

The Degrassi students return from a summer of activities a week before the new school year. Jake and Clare are still not talking, and their parents wedding sends Jake looking for space away from Clare. Katie is concerned that Bianca has been spending too much time with Drew, and Alli returns to Dave to find out he has cheated on her. Jake invites Katie, Drew, Marisol, and Alli to his remote cabin for a summer ending event, when Clare finds out, Bianca agrees to drive her. Clare arrives to find Alli kissing Jake, and runs into the woods, Jake and Drew follow, but Eli finds her first. Marisol freaks out when strange things start to happen, and Bianca keeps making references to horror movies. Marisol and Katie decide to relax with some weed Marisol found in the couch, but the two become paranoid in a shed. When repairing Clare's wound, Jake admits he still has feelings to her, the night ends with Clare and Jake's parents checking in on the party. The following morning Clare and Alli separate as friends, Katie becomes more comfortable with Bianca around, and Clare's and Jake's flirtation returns.

With a stressful day at school, Katie takes her mother's codeine during the day, despite sister Maya's warnings. Katie's knee gets too warn out before the soccer tryouts, and she requires surgery and recovery before being able to play again. After ex-boyfriend K.C. overhears Jenna's song about him, he writes a poem making Jenna's character a monster. Jenna keeps her song about how she is over K.C., and it is widely received well. Also at the coffee house, Tristan decides to sing without the Tori-Zig couple, but the two decide they will stick together, and Tristan does not get booed off the stage.