It is spring break for the students of Degrassi. Drew breaks curfew to attend a Keke Palmer concert with his girlfriend, Bianca. There she meets an ex-boyfriend, who is involved in a gang, and he takes her to an alley. Drew catches him trying to rape Bianca, and in the ensuing altercation, Bianca knocks him out, and loses her bracelet. Sav meets Palmer on the street, not knowing it is her, and she invites him to the concert, and then on stage with her. Fiona's vacation plans are scrubbed, and she instead attends an art class with Holly J., where she asks out the model.

Drew and Bianca find out that the gang member was killed, and she convinces him to keep quiet. When looking for Bianca's lost bracelet, she and Drew are told by another gang member, Vince, that they are going to be killed. In order to be kept safe, Drew finds out he must shoot someone to enter the gang. He then considers the situation, and turns himself into police. Sav, now with a crush on Keke Palmer, meets up with her, and she decides to elude her entourage with him. In a later video chat, Keke tells him she does have feelings for him. Fiona takes her date to her loft, where things move too quickly for Fiona, but they decide to first be friends, and then move on from there.

Clare cannot figure out why Eli has no feelings after their breakup. She then meets Jake, a transfer to Degrassi, and the son of her mother's friend. He helps her realize that it is her who still has feelings, and needs to deal with her relationship with Eli. The next day, Eli tells her he is taking anti-anxiety drugs. Jenna is overwhelmed with the baby, and gets mad that K.C. is not helping. After dumping the baby on him, they decide Jenna and Tyson should move in with K.C. and his mother.

Anya turns eighteen, and hopes to start dating a 26 year-old doctor, while Owen continues to flirt with her. She finds out the doctor will be in Africa for a year, and has sex with Owen at her birthday party. K.C. continues to struggle to be there for Jenna, and help with the baby, in the end he gets a job at Little Miss Steaks. Connor, struggling with his Asperger syndrome, shows an interest in girls, and steals a pair of Fiona's underwear, while attending a party. Drew meets with lawyers about the night he reportedly killed a gang member, and his mother continues to tell him Bianca is bad news for him.

After Drew is unable to get an erection, when he is trying to have sex with Bianca, he admits that he is still thinking about Vince, and the gang that is out to kill him. When Drew becomes distant with Bianca, she has sex with Vince, hoping he would leave Drew alone, and Drew would appreciate her again, but instead Drew breaks up with her, and gets beaten in a public place. Owen begins bragging about his one night stand, and Anya accidentally makes a public post on the internet that it was her. After disregarding what others think about Owen, she decides to go on a date with him. Connor continues to steal women's underwear, starting with Miss Oh's.

Dave and Adam vie for a position on the school's radio system, and Sav ends up giving them a two man show. When Adam is in the washroom trying to observe Dave's urinal stance, Dave mistakes it for a peak at his penis, then later when Adam tries to use a stand up to urinate device, Dave is curious, and Adam drops the device. Dave takes his frustrations to the radio show the next day, posing the questions if trannys should enter the boy's washroom, offending Adam. Fiona joins the grade 11 drama class, but instead skips school to spend time with Charlie. Clare writes a newspaper piece hoping to join the newspaper, but is overzealous, and does not get in because she wrote more than Katie had asked for.

Dave sees the school turn on him, but continues to ask why Adam should get special treatment. When he attempts to enter the girl's washroom wearing a skirt, he gets into a fight with Adam. Principal Simpson gives them both detention, and Adam likens the transgender issue to racism, which causes to Dave to give a formal apology. Clare continues to bag Katie for a position on the newspaper, and when Sav intervenes, Katie invites Clare to join, but gives her the job of following the school play. While Fiona tries to reach out to a distant Charlie, she gets the directing position of the play, and invites Charlie to live with her.

Eli, trying to write the school play, encounters writer's block, and meets the outlandish Imogen. K.C. works at a restaurant, and does not have time for Jenna and Tyson. Jenna gets upset when she hears he stayed late to party, Marisol's idea. Riley's mother still has not accepted that he is gay, so when she sets him up on a date with a girl, the date convinces him to keep acting straight.

Eli, with encouragement from Imogen, quits his anti-anxiety medication. He is able to have emotions, and writes the school play. Riley feels pressure from his parents to be straight, and asks Zane to act along, but decides not to put him through it, and breaks up with Zane. K.C. decides his job is keeping him from school and family and must quit. However, Marisol gets him a raise, and the two mutually flirt.

Not being accepted into her first university choice, Anya feels pressure from A student Holly J. and partying boyfriend Owen to make the right choices. To try to get away from it all, Anya decides to do cocaine. Fiona discovers bed bugs in her loft, and assumes it is her new roommate Charlie's, and in turn they learn about each other. Connor claims his girl underwear fetish is over, and plans to make a phone app for girl's clothing, but gets caught in the women's washroom.

Anya attends an interview to get her accepted into another university, but when it does not go well, she takes cocaine, and becomes erratic. When Anya does not get the university acceptance, she continues to take the drug, and defies her mother. Fiona struggles in telling Charlie her previous problems with alcohol, and learns she is still unable to be around it. Alli recognizes her clothes in Connor's app, and tells Principal Simpson, Connor was in the girl's washroom. Simpson suspends him, and he attends an academic behaviour program, to help him deal with his Asperger syndrome.

Jake and his father are helping Clare's mother with home renovations, and Clare sees Jake shirtless. Clare can not keep her mind off how handsome he is, and wants to start a relationship, but hears he asked Katie out. When talking about their parents, they decided to keep it casual. Drew is suffering from posttraumatic stress disorder when trying to fit back into school, he cannot handle the people at school, and asks his mother to move. Dave tries to convince himself that it is alright to be friends with Alli, but when he has to lie to his girlfriend about seeing her, he reconsiders.

Clare finds out her father cheated on her mother before they divorced, causing her to question her casual relationship with Jake. After she decides to be exclusive with Jake, they find out their parents are dating. Drew considers moving, which upsets his younger brother, Adam, when he can not handle the stresses at Degrassi, but instead takes up ultimate fighting (mixed martial arts). Dave's feelings for Alli intensify, so he decides to be truthful with his girlfriend, causing her to dramatically break-up with him.

Holly J. starts to look for a kidney donor within her family, and when she finds out no one has the same blood type, she starts to suspect she was adopted, which are proven true. Adam is attracted to Katie, and thinks she may be reciprocating this feeling, but when Marisol says otherwise, he worries about his female appearance. Imogen wants to play the role of Clare in the school play, so she begins shadowing her.

Holly J. finds her birth mother, and after mustering the strength to ask her to be a kidney donor, she asks Holly J. for $20,000. Adam worries that Katie is not attracted to him, because of his growing breasts, he asks to have surgery, but is too young, and instead wears a compression vest. Imogen has feelings for, and continues to flirt with, Eli, but she receives nothing in return.

Jenna struggles to find a way to attend Degrassi again, so K.C.'s mother agrees to watch the baby, Tyson, in the mornings. Jenna leaves Tyson unattended, and he falls off a table. Sav, with a crush on Miss Oh, competes to write the score for the school play. He wins, but is blackmailed into working with his competitor. When Clare finds out Eli has hired Jake to construct sets, she worries Eli is out to harm Jake.

Jenna and K.C. get a visit from child services, after Jenna finds out K.C. has been cheating with Marisol at work. Their arguments grow as K.C. continues to leave Tyson with Jenna, and they decide to break-up, and put Tyson up for adoption. Sav's love song to Miss Oh is leaked to her, and thinking things have been ruined between the two, Sav attends a concert, where he meets Miss Oh on a friendly basis. Clare is concerned Eli is jealous of Jake, but after reading the school play, she finds out Eli has made her character the hero.

Drew continues to train in mixed martial arts, with the mindset that he would be ready if anyone were ever to attack him. The news of unsupervised fighting gets to Principal Simpson, and he closes the weight room to unsupervised activities. Alli tries to sell Dave to her parents, but he feels that the presented self is not him. Holly J. finds out exchanging money for organs is illegal, and her birth mother is still not willing to give up her time and kidney for Holly J.

Drew continues to increase the intensity of his fights, hoping to distract him from his fear of being beaten. At an illegal fight club, a fight goes to far, and is stopped by Katie. Drew's new girlfriend then teaches him to direct his skill into taekwondo. Dave returns to Alli's parents, as himself, and her father takes a liking to him, but with a warning. Holly J. continues regular meetings with her birth mother, and when Fiona buys her old prom dress for $20,000, she agrees to donate her kidney.

Eli's unstable, off medication self, convinces he can start up a relationship with Clare, but everyone else, save Imogen, just find him crazy with the multiple script changes. K.C. and Jenna interview a couple to adopt the baby, but K.C. has second feelings when the prospective parents says they are not into sports. Anya continues her cocaine addiction, as she tries to find a career path, she sees an advertisement for the Canadian Forces.

Despite Imogen's efforts, Eli is obsessed with getting Clare back, to the point of framing Jake for drug possession. His feelings erupt at the end of the school play, in an improvised monologue, saying there are no happy endings in life. Anya's army application is rejected when she fails the drug test, and her secret is revealed to her mother, but she continues to pursue this career path. K.C. and Jenna give up their baby, Tyson for adoption.

Alli plans a date night in order to tell Dave she will be gone for the summer, and Dave presumes he is going to lose his virginity. The miscommunication causes Dave to stop talking to her, until she buys him NBA tickets with her poker winnings, which she obtains by card counting. Wesley is threatened by another male student, when he joins him and his girlfriend in a science project, Wesley then lies about driving to impress her. Bianca is threatened by a gang member into peddling drugs at Degrassi.

Alli finds an underground poker group, and becomes addicted. A game becomes too intense, and Dave must call his father to breakup the game, and ultimately the two. Wesley is pulled over while driving without a driver's permit, but his girlfriend remains by his side. Bianca becomes friends with Imogen.

Katie keeps her relationship with Drew secret from long time friend Marisol, which makes Marisol upset when she finds out. After Katie calls Marisol a home wrecker at a student council rally, Marisol reveals to Drew Katie's bulimia. Eli returns to Degrassi with some counseling, but is unable to apologize to Jake. Sav and Miss Oh flirt over music.

The rumors of Katie's bulimia circulate around Degrassi, and she worries that she will lose the presidential election. However, when it appears that the relationship between Katie and Marisol will end, Marisol says that the bulimia rumor was made up, winning the election for Katie. Eli helps Jake and Clare confess their love for each other. Sav's and Miss Oh's flirting continues, resulting in a trip to the principal's office, however they both seem interested.