Martin prepares to face his hearing, but despite having closed the practice, he finds all his patients are trying to make appointments. An American tourist who visited Portwenn previously returns to the town, hoping to research her family tree. However, she also has a medical issue, and comes to the troubled doctor seeking his advice. Louisa goes to see Chris to find out how serious the situation is, while the townsfolk take steps to show Martin how much he is appreciated.

Bert Large opens a restaurant in Portwenn, but when a food-poisoning alert appears to be connected to it, it could be a short-lived opening. When Louisa contracts food-poisoning, Martin is rather self-consciously forced to treat her in her bedroom.

After developing a sudden fear of blood, successful surgeon Dr. Martin Ellingham abandons London for a general practice in a quiet Cornish hamlet.

Quirky Doc Martin opens his village practice, only to discover that most of his 'patients' enjoy using his waiting room as a makeshift social club.

When a nasty stomach virus hits Portwenn, half the village takes ill, and Doc thinks he has traced the virus's source to the local swimming pool.

When one of his Aunt Joan's former beaus comes back to Portwenn to woo her, Doc must butt in after discovering the man has a serious heart condition.

Upon discovering Doc's fear of blood, the village starts buzzing with the news. Bert insists on playing a practical joke, but Doc isn't laughing.

As an excited Portwenn digests the news that Martin and Louisa are engaged, it's business as usual for the doctor. Beth Sawle's knee wound is not responding to the treatment he's prescribed, and when Martin visits the remote cottage where she lives with her strange sister Janet, he makes a disturbing discovery. Meanwhile, Bert's restaurant is in financial trouble, prompting son Al to take decisive action.

The villagers throw the Ellinghams a farewell party and Ruth helps Mrs Tishell deal with the news and encourages her to attend, but it seems that Martin and Louisa aren't going to make it because a farmer has spotted their lost dog.

Martin suspects Louisa may have anaemia. Aunt Joan is forced to receive treatment from Martin after nearly running someone over. The Doc is approached by Alison Lane, who worries about her daughter Delph's behaviour.

Dr Martin Ellingham and Pauline are surprised by the number of patients coming to see him on the last day before his Surgery closes and he moves to London.

A Salvation Army member arrives in Portwenn to try to trace a missing woman, Danny asks reluctant girlfriend Louisa to move into him, and PC Mark Mylow's medical check has a shock result.

Louisa is leaving for Spain, Bert and Jennifer's engagement party goes off with a bang, and Al is hailed as a hero for saving Caroline's life.

Martin and Louisa go on a date, but his usual bluntness ruins a romantic moment, and Louisa ends the struggling relationship. However, a friend of Louisa's visiting from the City, Holly, injures her back on the beach, and is forced to remain in Portween. Martin has to treat her at Louisa's house, while at the same time trying to overcome his own distraction at Louisa's dismissal of him.

It's Martin's wedding day and he manages to offend the vicar who is due to conduct the ceremony by suggesting he has a drink problem. When they struggle over a bottle of whisky, the vicar falls over, fracturing his pelvis and Martin has to find a replacement. Pauline suggests the former vicar of Delabole, who strikes a deal. He will conduct the wedding ceremony if Martin will examine his sick pig. Bert and Al are putting the finishing touches to the wedding banquet when disaster strikes. Last in the series.

Louisa has problems at school with Toby, Angela Sim’s Nephew. Meanwhile, Al has a ‘Large Whiskey’ order and has to ask Bert for some help, and Mrs Tishell seems to be having a delayed onset of mourning. Elsewhere, Martin and Louisa decide to try Mel’s suggestions of using amber beads to help James while he is teething.

Penhale decides to have a Police Open day to raise community awareness, but the only genuine visitor is an angry farmer who has had three of her sheep stolen. Meanwhile, Morwenna decides to take Al away for the weekend to try out Hannah’s new glamping site, but the trip does not go well as Al accidently burns down the yurt. Elsewhere, James has started biting not only Louisa but other children at the nursery. Louisa speaks to Tina about it, but is surprised to find out Tina has spoken to their lecturer about it too.

Martin wakes up to an empty bed. When he goes looking for Louisa he discovers she is trying to write her resignation letter.

Martin rushes to Ruth's for a medical emergency, and preparations for Morwenna and Al's wedding do not go to plan. Elsewhere, Martin takes his final GMC assessment under the watchful eye of eminent surgeon Bernard Newton, who monitors Martin's skills in assisted surgery.

The curmudgeonly GP struggles to come to terms with his new role as a father, having planned to resume his career as a consultant in London before the arrival of his and Louisa's as-yet unnamed son. To make matters worse, he begins to have serious doubts about the competency of his replacement Dr Di Dibbs when she misdiagnoses a patient as well as herself. Martin is then dealt a devastating personal blow after hearing his aunt Joan has died. (This Episode Is Rated TV-PG-V)

Mrs Tishell decides she can no longer hide her love for Martin and, fuelled by a cocktail of drugs, takes drastic action. While James Henry is in her care, she boards a bus out of Portwenn and leaves a message for Dr Ellingham to `meet them at the castle', forcing Martin, Louisa, Ruth and PC Penhale to mount a desperate search for the pair.

Martin and Louisa are about to get married but will it ever happen. Martin is feeling irritated by PC Penhale, who wrongly believes that he is going to be the best man and Louisa is also late for the service. The vicar has serious doubts as to whether she will turn up, leaving Martin on edge. After she finally arrives the couple are married. Things after the wedding don't go as Martin hoped and Ruth has a difficult time looking after James.

Martin's estranged parents charming Christopher and Margaret make a surprise visit, school secretary Maureen Tracey visits the doctor with what she thinks it is a thyroid problem, PC Mark Mylow announces he's getting engaged, and when Danny Steel collapses, Dr Ellingham has to carry out emergency surgery to save his life.

Martin's medical career remains under scrutiny, as a GMC representative has come to assess him and his surgery.

Ruth is concerned about becoming increasingly forgetful, and is even more perturbed when Martin offers to perform a mini mental state examination.