When two Chihuahuas are found abandoned in a storm drain, Dr. Jeff and his team will do whatever it takes to help them. Then Dr. Jeff makes a surprising discovery when a cat's bizarre eating habits put her life in danger.

Denver's busiest vet is back, with more patients than ever before. Dr. Jeff fights to help a dog walk again. Dr. Amy operates on a cat with a strange appetite. And the team heads out to a sanctuary to help an injured tiger.

Dr. Jeff operates on a dog rushed to the clinic after a growth on her neck ruptures. A family brings in their rabbit with mysterious growths on her side. And the team performs a risky procedure on a pair of rescued miniature donkeys.

An owner drives nine hours to the clinic hoping Dr. Jeff can save her dog's leg. Jeff and his team head to a wildlife sanctuary to treat a pack of wolves. And when a kitten with a deformed leg needs treatment, Dr. Baier steps up to the plate.

Two sisters rush their dog to the clinic with a life-threatening brain injury. Dr. Jeff is perplexed by a dog with a broken jaw. A fearless cat with a broken leg wins the admiration of the clinic staff. And the team treats some uncooperative yaks.

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Dr. Jeff battles to fix a German shepherd's broken elbow and get him back to his worried owner, a disabled war veteran; a cat with a swollen bladder needs difficult surgery to save its life; Drs. Baier and Hector head to an exotic bird sanctuary.

Dr. Jeff must act fast to save a bulldog after a life-threatening accident; when devastating floods hit Louisiana, Dr. Jeff sends vet tech Hector to rescue pets left homeless in the disaster; Dr. Don operates on a cat with a bad habit.

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In the Season 4 premiere, a black Lab swallows toxic metal; a lost cat is found after a one-and-a-half year absence, but has a mysterious injury; and a tiny dog has a big, life-threatening problem.

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Dr. Jeff performs emergency surgery on a pit bull and makes a surprising discovery. Dr. Baier treats a goat kicked by a horse. A couple drives all night hoping the team can fix their dog's shattered leg. And an injured ostrich is taken care of.

A high-risk surgery is attempted to save the life of a beloved puppy; a 3-day-old orphaned kitten needs Dr. Baier's help to stay alive; a puppy is given a fifty-fifty chance of survival after it's rushed to the clinic with a deadly virus.

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Dr. Jeff helps a remote town in Colorado overwhelmed by feral cats; a staff member's beloved dog needs emergency surgery; Dr. Baier gives some injured birds of prey a second chance; Jeff races to save the life of a family's precious Chihuahua.

Dr. Jeff performs surgery on Slash, a dog who can't keep his food down and weighs 20 pounds less than he should; Winter the cat has a bloody wound on his side.