When two Chihuahuas are found abandoned in a storm drain, Dr. Jeff and his team will do whatever it takes to help them. Then Dr. Jeff makes a surprising discovery when a cat's bizarre eating habits put her life in danger.

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In the Season 4 premiere, a black Lab swallows toxic metal; a lost cat is found after a one-and-a-half year absence, but has a mysterious injury; and a tiny dog has a big, life-threatening problem.

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Dr. Jeff performs emergency surgery on a pit bull and makes a surprising discovery. Dr. Baier treats a goat kicked by a horse. A couple drives all night hoping the team can fix their dog's shattered leg. And an injured ostrich is taken care of.

A high-risk surgery is attempted to save the life of a beloved puppy; a 3-day-old orphaned kitten needs Dr. Baier's help to stay alive; a puppy is given a fifty-fifty chance of survival after it's rushed to the clinic with a deadly virus.

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Dr. Jeff helps a remote town in Colorado overwhelmed by feral cats; a staff member's beloved dog needs emergency surgery; Dr. Baier gives some injured birds of prey a second chance; Jeff races to save the life of a family's precious Chihuahua.

When Dr. Jeff examines a beloved Weimaraner who has stopped eating, he makes a surprising discovery; Dr. Baier investigates the cause of a pet rabbit's mysterious fur loss; a servicewoman asks Dr. Jeff for help with her Pit Bull's injured leg.

Dr. Jeff must perform a rare surgery to save a pup with a deadly illness; a young pregnant woman counts on Dr. Amy to help her badly injured cat; Dr. Jeff and the team head to a wildlife sanctuary to treat a pride of lions.

Jeff and his team head to a remote town where they encounter an animal they never expected to see in Colorado; in Denver, a dog is rushed into the clinic after jumping out of a moving truck; Dr. Amy treats a kitten with a mysterious injury.

When a puppy is kicked in the head by a donkey, Dr. Jeff is her only hope. Later, Jeff goes fishing for a hook stuck in a beagle's throat, and Dr. Amy helps a cat unable to walk. And, Dr. Nichols gets caught up in a wrestling match with an alpaca.

Dr. Baier races to save a young couple's cat after it is hit by a truck. Dr. Don operates on a basset hound with an unusual appetite. And, Dr. Jeff and his team head to Mexico to provide desperately needed vet care to the community.

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