Drake has taken advantage of Josh for the last time and Josh decides that he is done dealing with Drake. Drake says he's fine with this, but when Josh's life improves and Drake's goes down the drain this rocker begins crooning a different tune.

Josh is confident about when Walter chooses him to be his co-weatherman. That is, until Megan reminds Josh of his uncontrolable twitch. So Josh twitches in front of the whole world and becomes the laughing stock of San Diego. Meanwhile, Drake is determined to win the talent show for the third year in a row but finds it challenging when he rivals with an acappella group.

Drake is getting tired of hanging around with Josh all the time. So Josh finds a friend named Drew who looks just like Drake. Drake feels he is being left out because of Drew, so he finds his own friend named Jerry who looks and acts like Josh.

It's the end of an era. After Josh ruins Drake's chances at having a hit song in the Superbowl, the boys must find a way to make things right.

Drake teases Josh that he can't get girls. So, Drake and Josh make a bet to see how many girls each of them can date in just one week. The rules are, every date must last at least one hour, you can't date someone you already know, and you can't date the same person twice.

After the boys get in trouble for using Fake ID's Audrey and Walter fear they will fall to a life of crime and sign them up for a “Steered Straight” program, but things start skidding out-of-control when a real criminal befriends them.

Drake meets a smart girl from school named Michelle that he really likes. Now, Drake is not the smartest kid in school, so he gets Josh to teach him things to impress Michelle. But things go too far when he accidentally says yes to an offer of joining the Academic Team. Meanwhile, Josh has had enough with Megan's pranks and tries to get back at her.

A new roller coaster is coming out called, the Demonator. Drake and Josh want to be there the first day it opens. But when they get in line, their wild adventure starts.

It's the end of an era. After Josh ruins Drake's chances at having a hit song in the Superbowl, the boys must find a way to make things right.

The whole gang has gathered at Drake and Josh's house before Drake's big concert, but thanks to Walter's poor weather predictions they end up stuck in the house due to severe rain. Sure, it's raining outside, but the real storm for Drake to weather is when his new girlfriend meets his exes.

Drake, Josh, and Megan must rebuild a tree house that they accidentally destroyed

Josh decides to enter a local dance contest, but when Drake realizes he's going to fail gym, he has to enter in order to receive high school credit. So he steals Josh's dance partner, and that's when things start to go wrong.

Drake and Josh make a bet to swear off junk food (Drake) and Video Games (Josh). Megan makes both of them swear to dye their hair pink (whoever loses). When Drake and Josh's mom and dad discover them making a bet, they make a bet as well. When things get crazy, Drake and Josh can't hold onto their bet much longer and decide to break it.

Drake finds out Josh is great at pool or billiards as Josh calls it. Drake bets some kids, and takes advantage of Josh's pool skills and starts hustling people, by taking their money, shoes and other clothing/personal items. Now Josh has made the ultimate bet, and Drake's stuffed in the corner pocket.

An obsessed fan is in love with Drake. She loves him so much, she says she's going to marry him and won't leave Drake a moments peace. So Drake must get this #1 fan to stop embarrassing him and ruining his life. Meanwhile, Josh becomes the new chief of the campfire kids but finds it tricky to deal with kids.

Drake is accused of parking Mrs. Hafer's car in the middle of her classroom. Drake and Josh must go in front of the school's Honor Council to prove Drake is innocent.

After accidentally punching Drake in school, Eric becomes very popular. Meanwhile, Josh thinks that Mindy has a new boyfriend.

Mindy tells Josh that she loves him and Josh slams the door in her face and runs to Drake, but Drake tells Josh that she is just trying to distract him so she can win the Science Fair.

The most popular kid in school is throwing what may be the greatest sixteenth party ever, but Drake and Josh may be having cake for two after they get banned from the party.

Drake tries to make Josh cool by telling him to try out for the football team. Instead, Josh gets "murdered" and he ends up being equipment manager, which isn't cool. Later, when the one of the player gets sick by Josh's brownies, the coach depends on Josh to play center. So now Drake must help Josh become cool and at the same time not actually play.

When Audrey and Walter go out of town for spring break they leave Drake, Josh, and Megan at home by themselves. When they are at the Premiere they overhear a couple saying that they don't have a place to stay. Drake and Josh take advantage of this opportunity and say that their vacant house is a hotel. Meanwhile, Megan is attempting to get Drake and Josh to treat her like a guest.

When Drake and Josh remember they got in a fight several years ago at a San Diego Padres game, they realize they fought each other. Then they spend the next few days fighting over who started the fight.

Josh is jazzed at the prospect of meeting his TV idol when Drake gets tickets to “Oprah” for his birthday, but delight turns to dismay in the studio parking lot.

Drake and Josh accidentally kill Megan's hamster and they think she is planning revenge.

Megan's been extremely secretive and Drake and Josh investigate to find out what she's up to. The clues lead to a new boyfriend and all seems wonderful until they find out Megan's new beau may be trouble.