Outlaw bikers fight cops and Chinese Triads to keep control of the crystal meth trade.

In Vancouver, a suburban gang war and heavy police presence drives some dealers and their customers to move downtown. But the cops are in hot pursuit.

Houston's drug hub is the 'Bloody Nickel' - the Fifth Ward. Five square miles of 24/7 drug and party action. Gangs work across the ethnic divide to keep the drugs flowing; while cops and Cartels vie with each other for control.

Since the days of Kurt Cobain and grunge music, Seattle has been nicknamed Junkietown. The city's liberal laws and high demand for drugs is attracting gangsters and dealers looking to get rich. From the competitive crack business in Belltown to fashionable Molly users on the electronic dance music scene, National Geographic explores the highs and lows of Seattle's drug business.

Phoenix, Ariz., is the wholesale drug capital of America, under the control of one of Mexico's most powerful and ruthless drug organizations -Â- the Sinaloa Cartel. Almost 200 miles north of the Mexican border, the city has become the major stopping off point for the large-scale distribution and transshipment of marijuana, heroin and methamphetamine up from Mexico and out to the rest of the country.

Its spring break in Florida and the wave of students means the demand for drugs is flooding the streets. In a month-long party, springbreakers’ drug of choice is “molly.” For local dealers, spring break is the busiest time of year.

In Kensington north Philadelphia, heroin, crack cocaine and PCP are dealt from a hundred different corners. Kensington is a giant drug drive thru. But for the addicts and dealers it's a deadly trap that threatens to drive them literally insane.

Behind the idyllic veneer of being one of the safest cities in the U.S, Salt Lake City is suffering from a massive drug epidemic. National Geographic pulls back the curtain and reveals the secret world of drug addiction in the Mormon community, the arrival of the cartels, and the dangers to the officers trying to control it.

After being rocked by a corruption scandal and a budget deficit in the range of 58 million dollars, the city's police department's staffing and morale are in bad shape. National Geographic follows an elite team of detectives who are trying to establish some control over the free for all drug market. Using their access to the dealers, users, and gang members at the heart of the problem NGC gives us a inside look at the drug infested city.

Heroin users in America began showing symptoms associated with Krokodil, a home-cooked opiate, including raw lesions, decaying skin and grotesque sores.

Known as Hillbilly Heroin, Opiate pain pills can be found in every town and city across the United States. From the poorest trailer home to the most expensive mansion, they are tearing apart the fabric of American society.

Denver - the mile high city - has just legalized recreational use of Marijuana. The city's gang-banger dealers have battled falling profits since medical Marijuana became law, and forced them to push new products. This latest move is last straw.

Miami - once America's cocaine capital; but no more. The War on Drugs has hit home. Today dealers and users play cat and mouse with the cops and live in dread of the Feds. And a new look drug scene has gone underground.

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Known by users as the ultimate “love drug,” ecstasy’s euphoric high comes with major lows: Ravers have died from it and organized crime gangs will kill for it.

Deep in the Amazon, Rob—a former Wall Street broker turned healer—has created a free clinic of sorts, administering the highly potent narcotic ayahuasca to trauma patients.

Music and drugs go hand in hand in Nashville. For musicians who don't make it, drugs are the easiest way to make a living. National Geographic talks to a user and freelance cook who makes methamphetamine at home to cover his costs and get high. Then, learn how the 19th Judicial District Drug Task Force is faced with cleaning up after meth cooks' Â- operations that are both extremely dangerous and prohibitively expensive.

Dominican drug networks tied directly to the Mexican cartel are distributing countless amounts of narcotics in the historic city of Boston, fueling a widespread epidemic that law enforcement and emergency services can hardly contain. The Dominican drug organizations are increasingly using Puerto Rican dealers as their middlemen to flood the city with heroin. The epidemic touches all communities, making Boston one of the leading cities for heroin distribution.

A look at the gangs that supply party goers with illegal drugs during New Year's Eve celebrations in New York City.

Heroin can be life threatening, claiming the lives of numerous victims. Follow this opium derivative as it begins in a remote Afghan heroin lab that processes the raw materials and then on to Chicago, where a dealer demonstrates its final preparation for street sale. Gain insight into its insidious powers from users, and witness a police raid on a heroin distribution network in New Jersey. Plus, go inside one radical attempt to combat heroin's social costs by supplying it free to addicts.

Cannabis is the most widely used illicit drug on the planet. To many, it's an evil weed, but to some, it's a sacred herb, even a lifesaver. For decades the global supply was controlled by criminals, but now a quasi-legal industry worth billions of dollars is booming. Visit growers who are leading a horticultural revolution, hear from users consuming for medicinal purposes, go inside the "Green Rush" of medical marijuana in cities across the U.S. and the violent marijuana cartels in Mexico.

Ketamine—chemically, a compound called ketamine hydrochloride—is a drug that was developed in the 1960s to sedate animals and humans for surgery, though it eventually was replaced by medications that worked faster with less risk. Beginning in the 1990s, initially to the puzzlement of police, burglars began breaking into veterinary clinics and stealing ketamine. They soon learned that recreational drug users had discovered ketamine and were turning it into the new hallucinogenic party drug. In its standard powdered form, ketamine looked like cocaine, and could be snorted in the same way. But it also could be easily modified for injecting, smoking or even mixing into drinks.

Inside the world of producers, traffickers, dealers, users, doctors, and cops who make up the multi-billion-dollar industry.

A former British gangster serves as guide into this illicit underworld, visiting a secret hash-making location nestled in the mountains.

A look at the fight against the country's most dangerous dealers and the biggest producers. From smuggling at JFK International Airport to cartel kingpins in Arizona, U.S law enforcement is fighting the global trade