Known by users as the ultimate “love drug,” ecstasy’s euphoric high comes with major lows: Ravers have died from it and organized crime gangs will kill for it.

Known as Hillbilly Heroin, Opiate pain pills can be found in every town and city across the United States. From the poorest trailer home to the most expensive mansion, they are tearing apart the fabric of American society.

Outlaw bikers fight cops and Chinese Triads to keep control of the crystal meth trade.

In Vancouver, a suburban gang war and heavy police presence drives some dealers and their customers to move downtown. But the cops are in hot pursuit.

Inside the world of producers, traffickers, dealers, users, doctors, and cops who make up the multi-billion-dollar industry.

Its spring break in Florida and the wave of students means the demand for drugs is flooding the streets. In a month-long party, springbreakers’ drug of choice is “molly.” For local dealers, spring break is the busiest time of year.

Behind the idyllic veneer of being one of the safest cities in the U.S, Salt Lake City is suffering from a massive drug epidemic. National Geographic pulls back the curtain and reveals the secret world of drug addiction in the Mormon community, the arrival of the cartels, and the dangers to the officers trying to control it.

After being rocked by a corruption scandal and a budget deficit in the range of 58 million dollars, the city's police department's staffing and morale are in bad shape. National Geographic follows an elite team of detectives who are trying to establish some control over the free for all drug market. Using their access to the dealers, users, and gang members at the heart of the problem NGC gives us a inside look at the drug infested city.

Heroin users in America began showing symptoms associated with Krokodil, a home-cooked opiate, including raw lesions, decaying skin and grotesque sores.

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Dominican drug networks tied directly to the Mexican cartel are distributing countless amounts of narcotics in the historic city of Boston, fueling a widespread epidemic that law enforcement and emergency services can hardly contain. The Dominican drug organizations are increasingly using Puerto Rican dealers as their middlemen to flood the city with heroin. The epidemic touches all communities, making Boston one of the leading cities for heroin distribution.

A look at the gangs that supply party goers with illegal drugs during New Year's Eve celebrations in New York City.

Heroin can be life threatening, claiming the lives of numerous victims. Follow this opium derivative as it begins in a remote Afghan heroin lab that processes the raw materials and then on to Chicago, where a dealer demonstrates its final preparation for street sale. Gain insight into its insidious powers from users, and witness a police raid on a heroin distribution network in New Jersey. Plus, go inside one radical attempt to combat heroin's social costs by supplying it free to addicts.

Cannabis is the most widely used illicit drug on the planet. To many, it's an evil weed, but to some, it's a sacred herb, even a lifesaver. For decades the global supply was controlled by criminals, but now a quasi-legal industry worth billions of dollars is booming. Visit growers who are leading a horticultural revolution, hear from users consuming for medicinal purposes, go inside the "Green Rush" of medical marijuana in cities across the U.S. and the violent marijuana cartels in Mexico.

A look at the fight against the country's most dangerous dealers and the biggest producers. From smuggling at JFK International Airport to cartel kingpins in Arizona, U.S law enforcement is fighting the global trade

The most powerful drug trafficking organization in the world, the Sinaloa Cartel, has found a new way to exploit American drug demand with Mexican super meth, a stronger and more addictive form of crystal meth.

The rapidly growing appetite for California Sour Diesel, a potent strain of marijuana said to induce an instant high, is helping fuel a violent drug underworld that stretches from coast to coast.

Ecstasy rebranded as pure MDMA is exploding in popularity while new-wave dealers try to distribute a molly alternative.

Some call methamphetamine the "Devil's Drug." Often made in less than an hour from a common cold remedy, this powerful stimulant is sweeping across the U.S. and Asia. Follow a raid on a suspected meth lab, stake out a neighborhood pharmacy where addicts attempt to accumulate cold and flu pills, and meet a neuroscientist urgently searching for a cure for addiction. See the dangers of meth and the unexpected physical damages caused by the drug.

The southwest border of the U.S. is the main gateway for illegal drugs, and Dallas, Texas, is often the first port of call for the Mexican cartel drug trade. In this episode, witness how the Mexican cartels have tainted Dallas by turning it into their command and control center for the trade of their narcotics. Buyers desperate to get a hold of the cartel's high-quality product flock to Dallas from all over the country, giving local dealers the chance to make big money

Baltimore, a once prosperous city, lost many of its jobs along with its steel mills. In return, the city developed one of the biggest heroin problems in the country. For many of those that remain amid the poverty and abandoned homes, the “Heroin Hustle” is the way of life. One strip of Pennsylvania Avenue alone is estimated to take in $10 million a year from heroin sales. With the business booming, the heroin market is expanding outward to the suburbs, and the authorities are struggling to cope.

Chicago, Illinois, is the drug hub of the Midwest and one of the most dangerous large cities in the United States. The Fourth of July is one of the bloodiest nights of the year and a time when the demand for drugs booms.

The supply chain of cocaine stretches around our world, bringing vast wealth to a few ... and misery to millions. Follow its trail through the eyes of peasant farmers producing cocaine paste, a trafficker tied to Mexican cartels and a 28-year-old crack dealer in Miami's poorest neighborhood. And literally see the true nature of cocaine addiction via revolutionary brain photography in a leading lab in Brookhaven, N.Y.

Ketamine—chemically, a compound called ketamine hydrochloride—is a drug that was developed in the 1960s to sedate animals and humans for surgery, though it eventually was replaced by medications that worked faster with less risk. Beginning in the 1990s, initially to the puzzlement of police, burglars began breaking into veterinary clinics and stealing ketamine. They soon learned that recreational drug users had discovered ketamine and were turning it into the new hallucinogenic party drug. In its standard powdered form, ketamine looked like cocaine, and could be snorted in the same way. But it also could be easily modified for injecting, smoking or even mixing into drinks.

For a few dollars, users can access dozens of compounds that mimic cocaine, ecstasy or marijuana. Sold as “Bath Salts” or “Spice,” these drugs are entirely legal.