Known by users as the ultimate “love drug,” ecstasy’s euphoric high comes with major lows: Ravers have died from it and organized crime gangs will kill for it.

Known as Hillbilly Heroin, Opiate pain pills can be found in every town and city across the United States. From the poorest trailer home to the most expensive mansion, they are tearing apart the fabric of American society.

Outlaw bikers fight cops and Chinese Triads to keep control of the crystal meth trade.

In Vancouver, a suburban gang war and heavy police presence drives some dealers and their customers to move downtown. But the cops are in hot pursuit.

Houston's drug hub is the 'Bloody Nickel' - the Fifth Ward. Five square miles of 24/7 drug and party action. Gangs work across the ethnic divide to keep the drugs flowing; while cops and Cartels vie with each other for control.

Since the days of Kurt Cobain and grunge music, Seattle has been nicknamed Junkietown. The city's liberal laws and high demand for drugs is attracting gangsters and dealers looking to get rich. From the competitive crack business in Belltown to fashionable Molly users on the electronic dance music scene, National Geographic explores the highs and lows of Seattle's drug business.

Some call methamphetamine the "Devil's Drug." Often made in less than an hour from a common cold remedy, this powerful stimulant is sweeping across the U.S. and Asia. Follow a raid on a suspected meth lab, stake out a neighborhood pharmacy where addicts attempt to accumulate cold and flu pills, and meet a neuroscientist urgently searching for a cure for addiction. See the dangers of meth and the unexpected physical damages caused by the drug.

Inside the world of producers, traffickers, dealers, users, doctors, and cops who make up the multi-billion-dollar industry.

Its spring break in Florida and the wave of students means the demand for drugs is flooding the streets. In a month-long party, springbreakers’ drug of choice is “molly.” For local dealers, spring break is the busiest time of year.

In Kensington north Philadelphia, heroin, crack cocaine and PCP are dealt from a hundred different corners. Kensington is a giant drug drive thru. But for the addicts and dealers it's a deadly trap that threatens to drive them literally insane.

Phoenix, Ariz., is the wholesale drug capital of America, under the control of one of Mexico's most powerful and ruthless drug organizations -Â- the Sinaloa Cartel. Almost 200 miles north of the Mexican border, the city has become the major stopping off point for the large-scale distribution and transshipment of marijuana, heroin and methamphetamine up from Mexico and out to the rest of the country.

Heroin users in America began showing symptoms associated with Krokodil, a home-cooked opiate, including raw lesions, decaying skin and grotesque sores.

Denver - the mile high city - has just legalized recreational use of Marijuana. The city's gang-banger dealers have battled falling profits since medical Marijuana became law, and forced them to push new products. This latest move is last straw.

Miami - once America's cocaine capital; but no more. The War on Drugs has hit home. Today dealers and users play cat and mouse with the cops and live in dread of the Feds. And a new look drug scene has gone underground.

Music and drugs go hand in hand in Nashville. For musicians who don't make it, drugs are the easiest way to make a living. National Geographic talks to a user and freelance cook who makes methamphetamine at home to cover his costs and get high. Then, learn how the 19th Judicial District Drug Task Force is faced with cleaning up after meth cooks' Â- operations that are both extremely dangerous and prohibitively expensive.

A look at the gangs that supply party goers with illegal drugs during New Year's Eve celebrations in New York City.

The most powerful drug trafficking organization in the world, the Sinaloa Cartel, has found a new way to exploit American drug demand with Mexican super meth, a stronger and more addictive form of crystal meth.

The rapidly growing appetite for California Sour Diesel, a potent strain of marijuana said to induce an instant high, is helping fuel a violent drug underworld that stretches from coast to coast.

Ecstasy rebranded as pure MDMA is exploding in popularity while new-wave dealers try to distribute a molly alternative.

Chicago, Illinois, is the drug hub of the Midwest and one of the most dangerous large cities in the United States. The Fourth of July is one of the bloodiest nights of the year and a time when the demand for drugs booms.

Ketamine—chemically, a compound called ketamine hydrochloride—is a drug that was developed in the 1960s to sedate animals and humans for surgery, though it eventually was replaced by medications that worked faster with less risk. Beginning in the 1990s, initially to the puzzlement of police, burglars began breaking into veterinary clinics and stealing ketamine. They soon learned that recreational drug users had discovered ketamine and were turning it into the new hallucinogenic party drug. In its standard powdered form, ketamine looked like cocaine, and could be snorted in the same way. But it also could be easily modified for injecting, smoking or even mixing into drinks.

For a few dollars, users can access dozens of compounds that mimic cocaine, ecstasy or marijuana. Sold as “Bath Salts” or “Spice,” these drugs are entirely legal.

The gambling mecca Sin City plays host to 40 million tourists a year. In storm drains beneath the Las Vegas strip, homeless addicts get high on crack in underground shanties, while in half-built suburbs, police battle marijuana gangs for control of the city's slump-hit homes.

New York City is in the grip of a heroin epidemic, as a new generation of middle-class suburbanite dealers hooked on prescription pills switch to heroin, and venture down the Long Island Expressway Â- dubbed the Heroin Highway into urban Brooklyn and Queens to get their fix.

Kingston is in the hands of highly organized and warring drug gangs. They manage drug trafficking and distribution at all levels. With the patronage of politicians, they fight hard to protect their turf in a city where poverty and guns drive the drug trade.