Known by users as the ultimate “love drug,” ecstasy’s euphoric high comes with major lows: Ravers have died from it and organized crime gangs will kill for it.

Known as Hillbilly Heroin, Opiate pain pills can be found in every town and city across the United States. From the poorest trailer home to the most expensive mansion, they are tearing apart the fabric of American society.

Outlaw bikers fight cops and Chinese Triads to keep control of the crystal meth trade.

In Vancouver, a suburban gang war and heavy police presence drives some dealers and their customers to move downtown. But the cops are in hot pursuit.

Some call methamphetamine the "Devil's Drug." Often made in less than an hour from a common cold remedy, this powerful stimulant is sweeping across the U.S. and Asia. Follow a raid on a suspected meth lab, stake out a neighborhood pharmacy where addicts attempt to accumulate cold and flu pills, and meet a neuroscientist urgently searching for a cure for addiction. See the dangers of meth and the unexpected physical damages caused by the drug.

Inside the world of producers, traffickers, dealers, users, doctors, and cops who make up the multi-billion-dollar industry.

Behind the idyllic veneer of being one of the safest cities in the U.S, Salt Lake City is suffering from a massive drug epidemic. National Geographic pulls back the curtain and reveals the secret world of drug addiction in the Mormon community, the arrival of the cartels, and the dangers to the officers trying to control it.

After being rocked by a corruption scandal and a budget deficit in the range of 58 million dollars, the city's police department's staffing and morale are in bad shape. National Geographic follows an elite team of detectives who are trying to establish some control over the free for all drug market. Using their access to the dealers, users, and gang members at the heart of the problem NGC gives us a inside look at the drug infested city.

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Dominican drug networks tied directly to the Mexican cartel are distributing countless amounts of narcotics in the historic city of Boston, fueling a widespread epidemic that law enforcement and emergency services can hardly contain. The Dominican drug organizations are increasingly using Puerto Rican dealers as their middlemen to flood the city with heroin. The epidemic touches all communities, making Boston one of the leading cities for heroin distribution.

A look at the fight against the country's most dangerous dealers and the biggest producers. From smuggling at JFK International Airport to cartel kingpins in Arizona, U.S law enforcement is fighting the global trade

The southwest border of the U.S. is the main gateway for illegal drugs, and Dallas, Texas, is often the first port of call for the Mexican cartel drug trade. In this episode, witness how the Mexican cartels have tainted Dallas by turning it into their command and control center for the trade of their narcotics. Buyers desperate to get a hold of the cartel's high-quality product flock to Dallas from all over the country, giving local dealers the chance to make big money

Baltimore, a once prosperous city, lost many of its jobs along with its steel mills. In return, the city developed one of the biggest heroin problems in the country. For many of those that remain amid the poverty and abandoned homes, the “Heroin Hustle” is the way of life. One strip of Pennsylvania Avenue alone is estimated to take in $10 million a year from heroin sales. With the business booming, the heroin market is expanding outward to the suburbs, and the authorities are struggling to cope.

Ketamine—chemically, a compound called ketamine hydrochloride—is a drug that was developed in the 1960s to sedate animals and humans for surgery, though it eventually was replaced by medications that worked faster with less risk. Beginning in the 1990s, initially to the puzzlement of police, burglars began breaking into veterinary clinics and stealing ketamine. They soon learned that recreational drug users had discovered ketamine and were turning it into the new hallucinogenic party drug. In its standard powdered form, ketamine looked like cocaine, and could be snorted in the same way. But it also could be easily modified for injecting, smoking or even mixing into drinks.

For a few dollars, users can access dozens of compounds that mimic cocaine, ecstasy or marijuana. Sold as “Bath Salts” or “Spice,” these drugs are entirely legal.

The gambling mecca Sin City plays host to 40 million tourists a year. In storm drains beneath the Las Vegas strip, homeless addicts get high on crack in underground shanties, while in half-built suburbs, police battle marijuana gangs for control of the city's slump-hit homes.

New York City is in the grip of a heroin epidemic, as a new generation of middle-class suburbanite dealers hooked on prescription pills switch to heroin, and venture down the Long Island Expressway Â- dubbed the Heroin Highway into urban Brooklyn and Queens to get their fix.

Washington, D.C., was once “Crack City” and the murder capital of the U.S. But an increased police presence following Sept. 11 made drugs scarce. In the neighborhoods of southeast D.C., one drug remained — PCP. And it's causing havoc. NGC goes inside the chaotic world of PCP where users think they're invincible and can be driven to insane acts of depravity. Visit the emergency room unit where doctors treat up to 80 psychotic patients high on PCP each month.

Portland's progressive attitudes have made it a mecca for America's homeless and they're helping fund the deadliest drug market in the Pacific Northwest. Here, pushers prey on the young, handing them free sample bags of narcotics to turn them into new customers. With thousands of Portland's youths succumbing to heroin's powerful allure, local police have made it their No. 1 priority to disrupt the flow into the city by smashing the local distribution networks.

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Molly, a powdered form of the drug MDMA, is exploding in popularity across the United States. Formerly marketed in pill form as Ecstasy, Molly is a total rebrand. Marketed as purer, cleaner and “without the additives,” this powder has become the most fashionable new drug for young people. But as the consumer demand for Molly has exploded, the production of pure MDMA has struggled to keep up with supply. As a result new, dangerous chemicals are finding their way into the market.

Chicago, the biggest open-air crack and heroin market in America is at saturation point. The result: record levels of overdoses and homicides, as gangs fight over drug turf.

The supply chain of cocaine stretches around our world, bringing vast wealth to a few ... and misery to millions. Follow its trail through the eyes of peasant farmers producing cocaine paste, a trafficker tied to Mexican cartels and a 28-year-old crack dealer in Miami's poorest neighborhood. And literally see the true nature of cocaine addiction via revolutionary brain photography in a leading lab in Brookhaven, N.Y.

Heroin can be life threatening, claiming the lives of numerous victims. Follow this opium derivative as it begins in a remote Afghan heroin lab that processes the raw materials and then on to Chicago, where a dealer demonstrates its final preparation for street sale. Gain insight into its insidious powers from users, and witness a police raid on a heroin distribution network in New Jersey. Plus, go inside one radical attempt to combat heroin's social costs by supplying it free to addicts.

Cannabis is the most widely used illicit drug on the planet. To many, it's an evil weed, but to some, it's a sacred herb, even a lifesaver. For decades the global supply was controlled by criminals, but now a quasi-legal industry worth billions of dollars is booming. Visit growers who are leading a horticultural revolution, hear from users consuming for medicinal purposes, go inside the "Green Rush" of medical marijuana in cities across the U.S. and the violent marijuana cartels in Mexico.