Will Ferrell and Seth Rogen star in this episode about how teenage writer Mary Shelley created her legendary novel, “Frankenstein.”

Mary Mallon spreads typhoid fever wherever she goes, and Cleopatra’s younger sister Arsinoe schemes her way in and out of power in Ancient Egypt.

John F. Kennedy’s doctor administers him meth for his back pain, and Dr. John C. Lilly takes LSD while studying the intelligence of dolphins.

Journalist Maurine Dallas Watkins writes a play about Chicago’s infamous Murderesses’ Row, and Mata Hari goes from exotic dancer to double agent during World War I.

Larry Walters pilots a balloon-suspended lawn chair, Phineas Gage survives an iron rod to the brain, and the Greenbrier Ghost’s testimony is used in court.

Hedy Lamarr designs the first modern airplane wing, Eartha Kitt's activism provokes the ire of Lady Bird Johnson, and Alexis Pulaski's poodle becomes a huge star.

Navy officer Douglas Hegdahl outwits his captors when he’s taken as a POW in North Vietnam, and Florence Nightingale revolutionizes the field of nursing.

Colonial gossip columnist James Callender winds up dead, a Hollywood producer dies on a celebrity-filled yacht, and Ken McElroy is murdered after terrorizing a Missouri town.

Martha Mitchell leaks the Watergate scandal to the press before Deep Throat does, and the Citizens’ Commission to Investigate the FBI stages an epic break-in.

A student tunnels beneath the Berlin Wall, Edie Windsor topples the Defense of Marriage Act, and John Wojtowicz robs a bank to pay for his wife’s gender reassignment surgery.

Lead Belly records songs with John Lomax that change the face of music, John Lennon and Yoko Ono almost get deported, and Sam Cooke writes “A Change Is Gonna Come.”

Forest service ranger Ed Pulaski saves 40 men from a forest fire, and Ted Patrick rescues teenagers from the psychological grip of the Children of God cult.

Moses Fleetwood Walker faces racism in the 19th century MLB, the Chicago White Sox throw the World Series, and the Callaghan sisters inspire the film "A League of Their Own."

Marina Raskova forms an all-women air force regiment to fight Nazis in World War II, and smuggler James J. Andrews hijacks a Confederate train for the Union.

John Muir convinces Teddy Roosevelt to preserve Yosemite, journalist Marjory Stoneman Douglas fights to protect the Everglades, and Native American activists occupy Alcatraz.

Bessie Coleman is America’s first black woman pilot, and the students of the Little Rock Nine integrate a high school following the Brown v. Board of Education decision.