In the season premiere, Ty takes the team to rebuild the home of a firefighter and his wife. After scraping every penny the family could get, they were able to cancel out their debts but realised they were unable to fix up their home. As the family head to Hawaii, the team move in and get to work.

Ty and the team head to the home of Chris Hampton who shares his home with 7 other people. After taking in their neices and nephews, the Hamptons have run out of room to house all 6 children the way they would like to.

Ty takes the team to Connecticut to repair the home of the Hill Family. The 13 family members are part of their own choir and help to inspire the community. A fire 16 years ago ruined their family home and they have since been unable to find the money to repair to it's former state.

Ty takes his designers to Texas to help remodel the home of Carlton and Susan. Carlton was shot whilst on duty with the police force and is now in a wheelchair. His daughter also has health problems and their home isn't practicably accessible for him to get around.

The team rebuilds the house of a man who gave up a lucrative engineering career to start a charity that feeds hungry people in his community.

Ty and the team travel to Daviess County to build a completely new home for the Mattinglys. Steve was involved in a major accident from which he has not fully recovered. Ty plans to replace the trailer they currently live in, with a brand new house.

Ty and the crew take a trip to Ohio where they rebuild the home of a wheelchair sports athlete who competed for the USA at the Paralympics.

Along with David Duchovny, the team travel to Lena where they set about rebuilding a farmhouse that was destroyed in an electrical fire.

"Grey's Anatomy" actor Patrick Dempsey joins Ty and the team as they remodel the moldy and rotting home of a famil whose son was diagnosed with leukemia and who started a campaign to raise money for and awareness of the disease.

Ty and the team travel to Clarksville, Tennessee to meet the Scott Family. Trina Scott met the love of her life, her husband Dave, while he was serving with the U.S. Army Special Forces. They went on to have three beautiful daughters: Leyla, Deidre and Alethea. After his discharge, Dave continued to serve his community by becoming a Clarksville police officer. Tragedy struck in 2002 when Dave was killed in the line of duty. Trina turned to C.O.P.S. (Concerns of Police Survivors, Inc.), an organization that helps the surviving family members of officers killed in the line of duty. Inspired by the support she received, Trina became president of the organization in 2003.

The Extreme Makeover Home Edition bus pulls up at the playground where Cynthia, Clara’s adult daughter, is playing with some of the children. She and the children rush to greet Ty, the Design Team, and a visibly moved Mary J. Blige. Ty loads them all on the bus to go to the house, where they surprise Clara and Bennie. After listening to a few of the kids describe what Clara means to them, Ty informs them they’re going to Walt Disney World! Clara, in her wheelchair, shows Ty the inside of the house. Mary J. Blige and Paige marvel that Clara can’t even get around in the home - and can’t even close her bathroom door! Mary says she saw neglected children when she was growing up, and becomes emotional as she tells Paige that she’s never seen someone care as much as Clara - she will make a difference to these kids’ lives. Paul checks out Bennie’s room, noting that he is almost legally blind, and that will have to be taken into consideration when designing his space.

Bunker Hill, IN is the destination for Ty's team where they are looking to makeover the home of Andy and Heather Cowan. Their daughter Kori became very ill and over time it has gotten worse - thought to be caused by the poor state of their home. Their son Adam has had to move out of the house due to him falling ill as well. Ty looks to put the family back together by giving them a new home.

Ty takes the team to Davidson County, NC to rebuild the home of Tricia Creasey. She has been battling with cancer but still teaches, despite her treatment costing over $1000 per month.

Ty takes the team to Florida to redo the home of Tobin and Jill who have dedicated their lives to providing a musical outlet, that is completely non-profitable, to the local community.

Ty takes the team to Davidson County, NC to rebuild the home of Tricia Creasey. She has been battling with cancer but still teaches, despite her treatment costing over $1000 per month.

Ty takes his team to Prince George's County, MD where he's going to help the Tripp family. Over the years they have helped the kids in the local community by running a bus service and offering activities, which they supervise to make sure they are kept safe in what is generally a rough area.

Ty takes the team to Florida to redo the home of Tobin and Jill who have dedicated their lives to providing a musical outlet, that is completely non-profitable, to the local community.

On February 1, 2010, "Extreme Makeover: Home Edition" traveled to Slaughterville, OK to meet Brian and Audra Skaggs, whose son, Jhett, survived a heart transplant at just 10 months of age. Although he's made incredible progress over the past two years, the poor condition of the family's moldy, rotting, termite-ridden home poses serious risks to Jhett's weakened immune system. In only seven days, team leader Ty Pennington, the design team, plus celebrity guest designer Jillian Harris of ABC's "The Bachelorette" will help build a safe and healthy home.

Ty takes his team to Hattiesburg, Mississippi to fix up the home of Sherman Heathcock who is currently in Iraq. After losing some of their home to Hurricane Katrina and getting conned when sorting out repairs, they don't have the time or money to do the repairs themselves.

Ty takes his team to Kemah, TX to rebuild the home of Larry and Melissa Beach. They have spent their lives looking after and adopting children. They currently have 13 kids, 9 of which live with them in a small trailer after Hurricane Katrina destroyed their home and possessions.

The team heads to Loris, SC to rebuild the home of Amanda and Derrick Suggs. Amanda has spent her life looking after her siblings and has only recently been able to get a good education. Derrick has helped look after them and also to help bring the local community closer to the police force by creating schemes to give them a better image.

Comic Bill Engvall helps the team rebuild a house for a family in Texas struggling to overcome physical challenges; surfer Bethany Hamilton spends time with the family while they vacation in Honolulu.

A family with a chronically ill child have their ancient, problem-ridden home rebuilt by Ty and his team. Sheryl Crow and Miranda Lambert perform and volunteer, and Sarah McLachlan has a message for the family.

In the Season 7 finale, a family with a dad who has Lou Gehrig's disease and a son with spina bifida get a rebuilt home with help from the NFL's Michael Oher and the Tuohy family, upon whom the movie "The Blind Side" is based. Also appearing: Demi Lovato; Wilmer Valderrama; and football analysts Herm Edwards, Mark Schlereth, Mark May and Desmond Howard.