The team jumps into action when analyst Kelly Moran is taken hostage.

When a trucker is gunned down after a routine trip from Canada, all signs point the team to a noted criminal on the FBI’s Most Wanted Terrorists list. Also, Jubal gets to work with an old friend and colleague, Detective Jack Lombardo.

All eyes are on the team when they try to find out who kidnapped the only child of a prominent U.S senator. The abduction also uncovers a potential link to a similar case that was pushed to the side by local authorities.

As the team works to rescue a 5-year-old kidnapping victim, Scola suspects the boy’s mother isn’t being forthcoming about why her son was targeted. Also, Nina struggles to open up to Scola about matters in their relationship.

A teen shows up at FBI headquarters with a large bag of fentanyl, seeking the team's protection from the men who shot his father; Nina goes to Scola with a proposal he is hesitant to accept.

When the deputy commander of an Air National Guard Base is kidnapped and forced to give over access codes, the team must work quickly to find the suspect along with stolen ammunition. Also, Scola questions his own safety in the aftermath of a recent traumatic experience.

When a prominent doctor is found dead in a ritualistic slaying, the team must race against time to hunt down a religiously motivated serial killer. Also, Scola faces a life-or-death decision.

The abduction of a young woman leads the team back to a cold case from 18 years ago, which pushes Isobel to reconnect with her old partner Jake and take another shot at solving one of her first cases in the bureau.

After a mysterious bioweapon leaves two MTA workers dead and one injured, the team rushes to determine who is behind the attack and the location of their next target; Jubal’s past demons begin to surface.

When an officer is shot dead at a pawn shop along with the store’s owner, the team tries to figure out why a young, recent Ivy League dropout is tied to the crime.

As the team investigates a deadly robbery that garnered a cache of automatic weapons for the killers, they discover one of the perps is a classmate of Jubal’s son, who is reluctant to cooperate with the case.

The team investigates a series of brutal assaults; OA hides information about his own mugging.

Maggie returns from medical leave in time to help the team investigate two homicides: a law student on track to attend the FBI Academy and a young man with possible gang ties. Also, an inadvertent revelation from Maggie causes OA to worry that she is rushing back into the job too quickly.

The team investigates the murder of a professional informant after he's found dead outside an abandoned factory in Red Hook. Also, Maggie reconnects with an old colleague and mentor.

To aid Scola in his undercover mission to find the terrorists believed to be behind the imminent attack in New York City, Maggie calls in Remy, whose well-connected informant from a prior case may be key to moving the operation forward. The crossover starts on FBI: International S02E16 Imminent Threat (I). It continues on FBI: Most Wanted S04E16 Imminent Threat (III).

The shooting of a federal corrections officer leads the team to an ex-Marine who has gone rogue ever since he returned from Afghanistan; Tiffany's sister looks to her for guidance when their younger brother begins to lash out.

A drug dealer is shot in a federal park and the team sets out to look for his killer; Maggie's sister returns to New York and complicates the case.

After finding a group of teens dead from a drug overdose, the team races to find the dangerous dealer and his supplier. Meanwhile, OA questions where he stands in his faith.

When an off-duty diplomatic security agent is fatally shot in New York City trying to apprehend someone, the team investigates if there's a connection to his time working in Croatia.

When a wealthy accountant is gunned down for secretly testifying against a notorious drug lord, the team’s investigation leads Tiffany to ask for help from a friend who was formerly with the NYPD and is related to the dangerous crime boss.

When a deadly truck heist arms the killers with enough ammonium nitrate to construct a massive bomb, the team discovers a link to a terrorist group Maggie is working to infiltrate.

After a string of armed robberies targets various businesses, the team investigates a suspect who leads them to something much bigger; OA worries about his future when his investments begin to go south.

The team pivots when their sting operation to secure a massive bomb from an illegal broker leads them to discover that the device is already in the wrong hands. Also, Jubal’s promise to be present at his son’s birthday party is put to the test as the case continues to heat up.