The Bubbler kidnaps the Shah of Shish-Ka-Bob and it's up to the Impossibles to rescue him.

Dr. Shock uses his Master Mix Monster Machine to turn his assistant Igor into an electricity-absorbing monster.

The Spinner steals a $1,000,000 tiara.

The Paper Doll Man steals a top secret plan and is out to steal the second part.

Professor Conroy and Buzz unveil the blueprints for the Spy Detector XK-00-7 at a Maximum Security Building. Unfortunately, the blueprints are targeted by the Spyder Man.

Beamatron steals a priceless painting from a ship.

The Burrower uses his burrowing machine to steal half a million dollars from the bank and dig ten miles down to his lair.

Upon an encounter with Buzz at the wax museum, Mr. Menace uses his monsters Godzonka, Gorillis and Cyclaws in an attack upon San Francisco.

Timeatron uses his time cabinet to bring villains from the past to pillage for him.

Smogula freezes the Impossibles and seals them within a cave, so they will not interfere with his plans to conquer Empire City.

A giant alien brain arrives on Earth and captures Buzz and Frankenstein Jr.

The Speck uses a formula to shrink himself in order to photograph top secret plans.

To get the Impossibles out of the way, Fero uses his fiddle to transport them to different planets.

A giant alien brain arrives on Earth and captures Buzz and Frankenstein Jr.

Mother Gruesome invents a machine that brings villainous storybook characters out of their stories to help her with her crimes.

Televisatron transports the Impossibles to different television shows.

The alien Zargon unleashes his warrior Destructo to conquer Earth.

The Dauber uses a special brush where anything he paints becomes real.

Aquator has stolen a secret formula from a scientist who is friends with Big D and shrinks himself to microscopic size in order to get all the microscopic creatures to become large.

Plant Man thaws the last three prehistoric plants (the Carnivorous Chewer, the Creeping Crusher and the Fire-Breathing Snapdragon) from a glacier and then sprays them with his Obedience Ray in a plot to eliminate Buzz and Frankenstein Jr.

Professor Stretch causes havoc with his elastic abilities.

The Dragster has stolen a valuable item.

The Mad Inventor has invented the Double Identity Duplicator Projector to create living images he can control.

The Spinner returns and steals a priceless pooch.

The Surfer takes pictures of a top secret submarine.