Three months after freeing Santanico from the Titty Twister, the Gecko Brothers are still on the run; Seth and Kate are lost in Mexico; Richie and Santanico plot vengeance on the culebra Lord.

Seth and Kate stage a heist, while Gonzalez endures frightening visions that lead to a grisly discovery, and back at the Twister, Malvado's plans are set into motion by Carlo's emergence from the labyrinth.

Richie and Santanico pose as sex traffickers to infiltrate Malvado’s food supply, while Sonja forces Seth to kick his drug habit. Meanwhile, Freddie faces off with Sex Machine, who attacks his family to retrieve the codex.

Kate hunts down Scott in Bethel before he can exact revenge. In Houston, Richie and Santanico find themselves deep in the flesh trade, while Seth tries to get back in Uncle Eddie’s good graces.

Richie and Seth make peace and team up to look for Malvado's headquarters. Meanwhile, Carlos kidnaps Santanico; and Kate tries to save her brother with help from Freddie.

Following the trail of the mass grave, Freddie and Kate uncover epic secrets and confront Oculto, a reclusive and dangerous Lord. Seth and Richie take the girls on a double date, and Carlos lets go of the past.

Uncle Eddie helps Rich and Seth make a plan to complete Santanico's revenge. Meanwhile, Freddie and Kate encounter an unexpected foe following Malvado's attack.

As the pieces of the big job fall into place, the uneasy trust between brothers and partners crumbles in the light of betrayals and new loyalties.

Santanico confronts Malvado with Seth's help; Richie and Kate must stop Carlos and Scott from overturning the ancient prophecy and taking control of a powerful evil.

Seth and Santanico clash with Richie over his betrayal, while Carlos and Scott aim to take Malvado’s empire and unleash culebra frenzy on the world.